Phenotypes Associated with This Genotype

Genotype
MGI:3789843

• Allelic Composition: Foxp2^tm1Momo/Foxp2^tm1Momo
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Small body and cerebellum size and abnormal cerebellar foliation in Foxp2^tm1Momo/Foxp2^tm1Momo mice

mortality/aging

perinatal lethality, incomplete penetrance ( J:132813 )

• approximately half of homozygotes are embryonic lethal or die at birth

embryonic lethality, incomplete penetrance ( J:132813 )

• approximately half of homozygotes are embryonic lethal or die at birth

growth/size/body

decreased body size ( J:132813 )

• homozygotes are about 30% smaller than wild-type at P10

decreased body weight ( J:132813 )

• at P10, homozygotes show a 30-40% reduction in mean weight, with a further weight reduction over the next 10 days

postnatal growth retardation ( J:132813 )

• homozygotes do not grow at a normal rate 20 days after birth

behavior/neurological

abnormal motor capabilities/coordination/movement ( J:132813 )

• homozygotes at P8-P10 show severe motor abnormalities, such as decreased spontaneous activity and sudden irregular and discoordinated movements

• by P14-P20, homozygotes are nearly unable to perform activities

impaired righting response ( J:132813 )

• homozygotes are delayed in their ability to right themselves when placed on their backs or in midair

• homozygotes show a difference from wild-type in the midair-righting assay

bradykinesia ( J:132813 )

• decrease in spontaneous activity at P8-P10

decreased vocalization ( J:132813 )

• at P10, mutant pups show severe impairment of ultrasonic vocalization when separated from mothers, producing only a few click-like vocalizations

• at P14-P20, do not produce any ultrasonic vocalization because of the severe loss of activity

nervous system

decreased brain size ( J:132813 )

abnormal cerebellum morphology ( J:132813 )

abnormal cerebellar foliation ( J:132813 )

• development of folia of the cerebellum is immature with less folia that are incompletely folded

abnormal cerebellar Purkinje cell layer ( J:132813 )

• calbindin-positive Purkinje cells are aligned in a continuous row but are sparsely localized in the folia

abnormal Purkinje cell dendrite morphology ( J:132813 )

• dendritic shafts of Purkinje cells are thin, with less elaborated calbindin-positive dendritic arbors and reduced synaptophysin reactivity

• dendrites remain at an immature level at P19

small cerebellum ( J:132813 )