Mouse Genome Informatics
cn
    Rb1tm3Tyj/Rb1tm3Tyj
Rbl2tm1Tyj/Rbl2tm1Tyj
Tg(Nes-cre)1Atp/0

involves: 129S2/SvPas * FVB/N
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• mice with mosaic cre expression due to maternal inheritance of Tg(Nes-cre)1Mrt exhibit an average tumor-free lifespan of 97 days but where sacrificed when moribund

vision/eye
• apoptosis levels are higher than in wild-type mice but not higher than in Rb1tm3Tyj/Rb1tm3Tyj Tg(Nes-cre)1Mrt mice

tumorigenesis
• mice with mosaic cre expression due to maternal inheritance of Tg(Nes-cre)1Mrt exhibit bilateral retinoblastomas that invade surrounding muscle, exhibit rosettes, have foci with high levels of apoptosis and mitoses and are of amacrine lineage

reproductive system
• fewer than expected mice are produced with maternal inheritance of Tg(Nes-cre)1Mrt

cellular
• apoptosis levels are higher than in wild-type mice but not higher than in Rb1tm3Tyj/Rb1tm3Tyj Tg(Nes-cre)1Mrt mice

Mouse Models of Human Disease
OMIM IDRef(s)
Retinoblastoma; RB1 180200 J:91406