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Phenotypes Associated with This Genotype
Genotype
MGI:3783528
Allelic
Composition
Rb1tm3Tyj/Rb1tm3Tyj
Rbl2tm1Tyj/Rbl2tm1Tyj
Tg(Nes-cre)1Atp/0
Genetic
Background
involves: 129S2/SvPas * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rb1tm3Tyj mutation (1 available); any Rb1 mutation (59 available)
Rbl2tm1Tyj mutation (1 available); any Rbl2 mutation (18 available)
Tg(Nes-cre)1Atp mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice with mosaic cre expression due to maternal inheritance of Tg(Nes-cre)1Mrt exhibit an average tumor-free lifespan of 97 days but where sacrificed when moribund

vision/eye
• apoptosis levels are higher than in wild-type mice but not higher than in Rb1tm3Tyj/Rb1tm3Tyj Tg(Nes-cre)1Mrt mice
• mice with mosaic cre expression due to maternal inheritance of Tg(Nes-cre)1Mrt exhibit bilateral retinoblastomas that invade surrounding muscle, exhibit rosettes, have foci with high levels of apoptosis and mitoses and are of amacrine lineage

tumorigenesis
• mice with mosaic cre expression due to maternal inheritance of Tg(Nes-cre)1Mrt exhibit bilateral retinoblastomas that invade surrounding muscle, exhibit rosettes, have foci with high levels of apoptosis and mitoses and are of amacrine lineage

reproductive system
• fewer than expected mice are produced with maternal inheritance of Tg(Nes-cre)1Mrt

cellular
• apoptosis levels are higher than in wild-type mice but not higher than in Rb1tm3Tyj/Rb1tm3Tyj Tg(Nes-cre)1Mrt mice

Mouse Models of Human Disease
OMIM ID Ref(s)
Retinoblastoma; RB1 180200 J:91406


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory