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Phenotypes Associated with This Genotype
Genotype
MGI:3713721
Allelic
Composition
Nr4a1tm1Jmi/Nr4a1tm1Jmi
Nr4a3tm1Omc/Nr4a3tm1Omc
Genetic
Background
involves: 129S/SvEv * 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr4a1tm1Jmi mutation (3 available); any Nr4a1 mutation (33 available)
Nr4a3tm1Omc mutation (1 available); any Nr4a3 mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice fail to thrive and die between 2 - 4 weeks after birth

neoplasm
• acute myeloid leukemia that is rapidly lethal and transplantable
• perivascular infiltrates are seen in nonhematopoietic tissues including the liver and lung
• disseminated myeloid cells are seen in the spleen and lung

hematopoietic system
• severe disruption of the architecture at 2 - 3 weeks of age
• significant expansion of myeloid progenitors
• immature blasts make up as much as 80% of white blood cells
• increase in the number of CD11b+ progenitor cells and these cells display a significant increase in the number of cells in the S and G2/M phases of the cell cycle
• at 2 -3 weeks of age
• reduction in the number of lymphoid and erythroid cells and increase in the number of granulocytes
• marked reduction of the number of lymphoid cells in the spleen, bone marrow, and thymus
• variable incidence of leukocytosis at 2 -3 weeks of age
• however, all homozygotes show an increase in immature/blast myeloid forms in the bone marrow, spleen, and peripheral blood
• marked expansion of granulocytes in the bone marrow, spleen, thymus, and lymph nodes
• variable incidence of eosinophilia at 2 -3 weeks of age
• variable incidence of eosinophilia at 2 -3 weeks of age
• 2.6-fold increase in the number of long term hematopoietic stem cells in bone marrow
• however, the number of short term hematopoietic stem cells is not increased
• severe disruption of the architecture at 2 - 3 weeks of age
• at 2 -3 weeks of age

growth/size/body
• at 2 -3 weeks of age
• at 2 -3 weeks of age

behavior/neurological

liver/biliary system
• at 2 -3 weeks of age

immune system
• severe disruption of the architecture at 2 - 3 weeks of age
• immature blasts make up as much as 80% of white blood cells
• increase in the number of CD11b+ progenitor cells and these cells display a significant increase in the number of cells in the S and G2/M phases of the cell cycle
• marked reduction of the number of lymphoid cells in the spleen, bone marrow, and thymus
• variable incidence of leukocytosis at 2 -3 weeks of age
• however, all homozygotes show an increase in immature/blast myeloid forms in the bone marrow, spleen, and peripheral blood
• marked expansion of granulocytes in the bone marrow, spleen, thymus, and lymph nodes
• variable incidence of eosinophilia at 2 -3 weeks of age
• variable incidence of eosinophilia at 2 -3 weeks of age
• severe disruption of the architecture at 2 - 3 weeks of age
• at 2 -3 weeks of age
• at 2 -3 weeks of age

integument

endocrine/exocrine glands
• severe disruption of the architecture at 2 - 3 weeks of age

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
acute myeloid leukemia DOID:9119 OMIM:601626
J:121903


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/13/2022
MGI 6.21
The Jackson Laboratory