Phenotypes Associated with This Genotype

Genotype
MGI:3707398

• Allelic Composition: Fas^lpr/Fas^lpr
• Genetic Background: B6.MRL-Fas^lpr/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased B cell apoptosis ( J:135830 )

• after bile duct ligation (BDL), Peyer's patch B cells do not display evidence of apoptosis

increased immature B cell number ( J:132217 )

• plasmablast numbers in spleen are increased relative to wild-type

increased transitional stage B cell number ( J:132217 )

• higher numbers of T2 B cells in spleen relative to wild-type

increased follicular B cell number ( J:132217 )

• higher in spleen relative to wild-type

increased marginal zone B cell number ( J:132217 )

• higher in spleen relative to wild-type, Fas^lpr homozygotes, and Bcl2l11-deficient mice

abnormal splenic cell ratio ( J:132217 )

• T1:follicular B cell ratio is higher than wild-type or Bcl2l11-deficient mice

increased splenocyte number ( J:132217 )

• total number of CD19+ splenocytes is higher than wild-type

• total number of splenocytes is increased relative to wild-type

abnormal NK cell physiology ( J:115033 )

• continuous treatment with recombinant murine IL12 results in sustained recruitment of NK cells to the liver

enlarged lymph nodes ( J:119584 )

• mice develop less severe lymphadenopathy at later ages than the double mutant Igh-6/Fas mice

lymph node hyperplasia ( J:132217 )

• total number of cells per lymph node is increased compared to wild-type

increased autoantibody level ( J:132217 )

• total anti-IgM antibody levels are increased compared to wild-type

increased anti-nuclear antigen antibody level ( J:132217 )

• anti-nuclear antibodies are increased compared to wild-type

increased anti-double stranded DNA antibody level ( J:132217 )

• anti-ssDNA IgM and IgG antibodies are increased compared to wild-type

increased anti-histone antibody level ( J:132217 )

• increased compared to wild-type

increased anti-single stranded DNA antibody level ( J:132217 )

• anti-ssDNA IgM and IgG antibodies are increased compared to wild-type

CNS inflammation ( J:120427 )

brain inflammation ( J:120427 )

• by 7 days after TMEV infection, inflammation is present, decreasing slightly by 21 days, but widespread tissue damage is present, similar to controls (B6)

• tissue damage is less frequent at 45 days than in Prf-null mice

increased susceptibility to bacterial infection ( J:136745 )

• mice infected with 500 CFU of S. aureus have drastically elevated number of S. aureus CFU compared to similarly-infected wild-type mice, but lower counts than infected Fasl^gld mice

increased susceptibility to Picornaviridae infection ( J:120427 )

• inflammation and tissue damage in the brain are slightly greater than in control, resistant mice at 45 and 180 days

hematopoietic system

decreased B cell apoptosis ( J:135830 )

• after bile duct ligation (BDL), Peyer's patch B cells do not display evidence of apoptosis

increased immature B cell number ( J:132217 )

• plasmablast numbers in spleen are increased relative to wild-type

increased transitional stage B cell number ( J:132217 )

• higher numbers of T2 B cells in spleen relative to wild-type

increased follicular B cell number ( J:132217 )

• higher in spleen relative to wild-type

increased marginal zone B cell number ( J:132217 )

• higher in spleen relative to wild-type, Fas^lpr homozygotes, and Bcl2l11-deficient mice

abnormal splenic cell ratio ( J:132217 )

• T1:follicular B cell ratio is higher than wild-type or Bcl2l11-deficient mice

increased splenocyte number ( J:132217 )

• total number of CD19+ splenocytes is higher than wild-type

• total number of splenocytes is increased relative to wild-type

abnormal NK cell physiology ( J:115033 )

• continuous treatment with recombinant murine IL12 results in sustained recruitment of NK cells to the liver

renal/urinary system

increased renal glomerulus apoptosis ( J:132217 )

• higher numbers of apoptotic cells are detected in glomeruli compared to wild-type

abnormal kidney morphology ( J:132217 )

• number of macrophages surrounding glomeruli is increased compared to wild-type which have no macrophage index

abnormal renal glomerulus basement membrane morphology ( J:132217 )

• IgG deposits mainly localized to glomerular basement membrane are increased relative to wild-type

liver/biliary system

abnormal hepatocyte morphology ( J:135830 )

• confluent foci of feathery hepatocyte degeneration due to bile acid cytotoxicity are significantly reduced compared to controls hours after BDL

focal hepatic necrosis ( J:135830 )

• necroinflammatory foci after BDL are reduced in number compared to controls

abnormal liver physiology ( J:120559 , J:135830 )

• when mice are recipients of wild-type hepatitis B surface antigen (HBsAg)-specific Th1 cells after treatment with HBsAg, severe liver injury is induced to similar extent as in wild-type mice (J:120559)

• treatment with Prf1-deficient HBsAg-specific Th1 cells and HBsAg induces liver injury as severe as that induced by wild-type HBsAg-specific Th1 cells (J:120559)

• after BDL, necroinflammatory foci and lymphocytic infiltration are obviously less than in controls (J:135830)

decreased hepatocyte apoptosis ( J:135830 )

• hepatocyte cell death is reduced compared to controls after BDL

nervous system

CNS inflammation ( J:120427 )

brain inflammation ( J:120427 )

• by 7 days after TMEV infection, inflammation is present, decreasing slightly by 21 days, but widespread tissue damage is present, similar to controls (B6)

• tissue damage is less frequent at 45 days than in Prf-null mice

demyelination ( J:120427 )

• by 7 days after TMEV infection, inflammation is present in the meninges and gray matter of spinal cord, but decreases by 21 days, although not as much as in controls (B6)

cellular

decreased B cell apoptosis ( J:135830 )

• after bile duct ligation (BDL), Peyer's patch B cells do not display evidence of apoptosis

increased renal glomerulus apoptosis ( J:132217 )

• higher numbers of apoptotic cells are detected in glomeruli compared to wild-type

decreased hepatocyte apoptosis ( J:135830 )

• hepatocyte cell death is reduced compared to controls after BDL