Phenotypes Associated with This Genotype

Genotype
MGI:3624695

• Allelic Composition: Tg(KRT5-CDK4)2303Mlrp/0
• Genetic Background: involves: FVB * SSIN

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal cell morphology ( J:108690 )

• cells in the interfollicular epidermis and the hair follicles of transgenics show an increase in the size of the nucleus compared to wild-type littermates

integument

abnormal dermal layer morphology ( J:108690 )

• dermal fibrosis with severe hypoplasia of the subcutaneous adipose tissue is observed

thick dermal layer ( J:108690 )

• thickness of dermal layer is increased 2.8-fold in transgenics over wild-type

abnormal epidermis stratum basale morphology ( J:108690 )

• number of proliferating cells in epidermis of transgenic mice is 4-fold higher compared to wild-type

abnormal epidermis stratum granulosum morphology ( J:108690 )

• layer is significantly increased compared to granule layer in wild-type

abnormal epidermis stratum spinosum morphology ( J:108690 )

• layer is significantly increased compared to spinous layer in wild-type

thick epidermis ( J:108690 )

• epidermis is hyperplastic; average thickness of the epidermis of transgenic mice is 2-fold greater than in wild-type