Phenotypes Associated with This Genotype

Genotype
MGI:3619937

• Allelic Composition: Pik3cg^tm1Pngr/Pik3cg^tm1Pngr; Pten^tm2Mak/Pten^tm2Mak; Tg(Ckmm-cre)5Khn/0
• Genetic Background: involves: 129P2/OlaHsd * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

enlarged heart ( J:79151 )

• significantly enlarged compared to wild-type and single homozygous Pik3cg^tm1Pngr mice

cardiac hypertrophy ( J:79151 )

• extent of cardiac hypertrophy is similar to that seen in mice with cardiomyocyte-specific inactivation of Pten

increased cardiac muscle contractility ( J:79151 )

• hearts are hypercontractile as assessed by increased fractional shortening, velocity or circumferential fiber shortening, and peak aortic outflow velocity

• individual cardiomyocytes display increased contractility despite the hypertrophy

muscle

increased cardiac muscle contractility ( J:79151 )

• hearts are hypercontractile as assessed by increased fractional shortening, velocity or circumferential fiber shortening, and peak aortic outflow velocity

• individual cardiomyocytes display increased contractility despite the hypertrophy

growth/size/body

enlarged heart ( J:79151 )

• significantly enlarged compared to wild-type and single homozygous Pik3cg^tm1Pngr mice

cardiac hypertrophy ( J:79151 )

• extent of cardiac hypertrophy is similar to that seen in mice with cardiomyocyte-specific inactivation of Pten