Phenotypes Associated with This Genotype

Genotype
MGI:3578950

• Allelic Composition: Gab1^tm1Gsf/Gab1^tm1Gsf; Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal glucose homeostasis ( J:98318 )

decreased circulating glucose level ( J:98318 )

• blood glucose levels are reduced in homozygotes from 9.1 to 28.9% in both the fed and fasted states compared to gender and age matched wild-type mice

decreased circulating insulin level ( J:98318 )

• serum insulin levels are reduced at 2 months and 1 year of age

improved glucose tolerance ( J:98318 )

• both glucose injection and glucose clamp assays indicate improved glucose tolerance

decreased glycogen level ( J:98318 )

• glycogen levels are reduced in 1 year old mutants; however circulating glyconeogenic precursor levels are normal

increased insulin sensitivity ( J:98318 )

• peripheral and hepatic insulin sensitivity are increased

abnormal lipid homeostasis ( J:98318 )

decreased circulating free fatty acids level ( J:98318 )

• free fatty acid plasma levels are mildly reduced

decreased circulating triglyceride level ( J:98318 )

• retention of triglycerides in the liver is increased and circulating levels are decreased