Gab1^tm1Gsf
Targeted Allele Detail

Summary

• Symbol: Gab1^tm1Gsf
• Name: growth factor receptor bound protein 2-associated protein 1; targeted mutation 1, Gen-Sheng Feng
• MGI ID: MGI:3578648
• Synonyms: Gab1^flox
• Gene: Gab1 Location: Chr8:81491067-81607148 bp, - strand Genetic Position: Chr8, 38.47 cM, cytoband C3
• Alliance: Gab1^tm1Gsf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:98318
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Loxp sites were inserted to flank exon 3. (J:98318)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gab1 Mutation: 78 strains or lines available

References

• Original: J:98318 Bard-Chapeau EA, et al., Deletion of Gab1 in the liver leads to enhanced glucose tolerance and improved hepatic insulin action. Nat Med. 2005 Jun;11(6):567-71
• All: 15 reference(s)