Mouse Genome Informatics
cx
    Adatm1Mw/Adatm1Mw
Tg(PLADA)4118Rkmb/0

involves: 129S7/SvEvBrd * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       

Structural alterations in the thymus and spleen of Adatm1Mw/Adatm1Mw Tg(PLADA)4118Rkmb/0 mice

mortality/aging
• death by 3 weeks of age

hematopoietic system
• with decreased cortical-medullary demarcation
• in both thymus and spleen
• with decreased numbers of red blood cells and few megakaryocytes observed
• lymphoid counts substantially reduced

immune system
• with decreased cortical-medullary demarcation
• in both thymus and spleen
• with decreased numbers of red blood cells and few megakaryocytes observed
• lymphoid counts substantially reduced
• evidence of inflammatory cells, thickening and shedding of airway epithelium and occlusion of airways with mucous and cellular debris

renal/urinary system
• increased red blood cells within glomeruli
• increased red blood cells within convoluted tubules

respiratory system
• evidence of inflammatory cells, thickening and shedding of airway epithelium and occlusion of airways with mucous and cellular debris
• evident beginning at postnatal day 12 and progressively labored breathing until death

skeleton
• enlarged costochondral junctions
• severe rib curvature

endocrine/exocrine glands
• with decreased cortical-medullary demarcation

Mouse Models of Human Disease
OMIM IDRef(s)
Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Negative, Nk Cell-Negative, Due to Adenosine Deaminase Deficiency 102700 J:73418