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Phenotypes Associated with This Genotype
Genotype
MGI:2653295
Allelic
Composition
Leprtm1Mgmj/Leprtm1Mgmj
Genetic
Background
B6.129-Leprtm1Mgmj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Leprtm1Mgmj mutation (1 available); any Lepr mutation (37 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• body weight is 2- to 3-fold more than in wild-type mice by 10 weeks of age (J:82334)
• however, body weight is 10% and 20% less in males and females, respectively, compared to Leprrdb homozygotes (J:82334)
• body weight is 2- to 3-fold more than in wild-type mice by 10 weeks of age (J:82334)
• however, body weight is 10% and 20% less in males and females, respectively, compared to Leprrdb homozygotes (J:82334)
• snout to anus length is increased by about 5% compared to wild-type mice (J:82334)
• snout to anus length is increased by about 5% compared to wild-type mice (J:82334)

behavior/neurological

homeostasis/metabolism
• increased neointimal hyperplasia relative to Leprdb 4 weeks after femoral artery injury (J:135034)
• increased neointimal hyperplasia relative to Leprdb 4 weeks after femoral artery injury (J:135034)
• mice pair-fed with wild-type mice gain more weight and adipose tissue than wild-type mice (J:82334)
• mice pair-fed with wild-type mice gain more weight and adipose tissue than wild-type mice (J:82334)
• increase in glucose is less than in Leprrdb homozygotes (J:82334)
• increase in glucose is less than in Leprrdb homozygotes (J:82334)

reproductive system
• slight delay in the onset of oestrous cycling, median onset at 42 days rather than 36 days as in wild-type mice (J:82334)
• however, all females show signs of vaginal oestrous and no defects in ovulation are seen (J:82334)
• slight delay in the onset of oestrous cycling, median onset at 42 days rather than 36 days as in wild-type mice (J:82334)
• however, all females show signs of vaginal oestrous and no defects in ovulation are seen (J:82334)
• only about 40% of females are fertile (J:82334)
• only about 40% of females are fertile (J:82334)

endocrine/exocrine glands
• pups born to homozygous females die within 24 h without milk in their stomachs unless fostered to wild-type mothers (J:82334)
• pups born to homozygous females die within 24 h without milk in their stomachs unless fostered to wild-type mothers (J:82334)

cardiovascular system
• increased neointimal hyperplasia relative to Leprdb 4 weeks after femoral artery injury (J:135034)
• increased neointimal hyperplasia relative to Leprdb 4 weeks after femoral artery injury (J:135034)
• similar to to Leprdb (J:135034)
• similar to to Leprdb (J:135034)

integument
• pups born to homozygous females die within 24 h without milk in their stomachs unless fostered to wild-type mothers (J:82334)
• pups born to homozygous females die within 24 h without milk in their stomachs unless fostered to wild-type mothers (J:82334)

Mouse Models of Human Disease
OMIM ID Ref(s)
Obesity 601665 J:82334


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory