Analysis Tools
mortality/aging
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• most mutants are dead at E10 and all die by E11
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embryo
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• show a deficit in posterior development at E9
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• growth arrest at the 14 somite stage
(J:25248)
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• embryos are smaller at E9
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• neural tube kinks are seen extending posterior to the forelimb
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• the notochord degenerates after growth arrest
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• mutants exhibit a lack of coordination in segmentation of the somites, leading to variable somite size and misalignment of the somites across the midline of the embryo
(J:25248)
• transition from presomitic mesoderm to the somite is disordered
(J:25248)
• the most recently formed somites are not as tightly packed as those of wild-type and the epithelialization sometimes appears incomplete
(J:25248)
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• lack of coordination across the midline in the segmentation of somites, where segmentation is sometimes present on one side but not the other
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• variable somite size
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• mutants exhibit a delay in segmentation of the somites
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growth/size/body
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• embryos are smaller at E9
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cardiovascular system
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• distended pericardia at E9
(J:25248)
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cellular
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• an increase in cell death is seen in embryos after they arrest
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nervous system
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• neural tube kinks are seen extending posterior to the forelimb
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