Analysis Tools
adipose tissue
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• increase in body fat content beginning at puberty
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behavior/neurological
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• decrease in locomotor activity
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growth/size/body
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• mice gain more weight than controls at thermos neutrality (32-33 degrees Celcius)
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• mice fed a high-fat diet exhibit increased body weight and body fat content
• high-fat diet fed mice treated with the Scd1 inhibitor A939572 show normalization of body weight gain and abnormal body composition
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homeostasis/metabolism
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• increase in circulating insulin levels
• high-fat diet fed mice exhibit higher insulin levels
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• mice fed a high-fat diet exhibit increased body weight and body fat content
• high-fat diet fed mice treated with the Scd1 inhibitor A939572 show normalization of body weight gain and abnormal body composition
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• decrease in energy expenditure
• however, mice show normal food intake and respiratory exchange ratios
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• mice develop impaired tolerance to an intraperitoneal glucose load as early as 16 weeks after birth and remain glucose intolerant throughout life
• high-fat diet further impairs glucose tolerance
• mice treated with the Scd1 inhibitor A939572 show improved glucose tolerance
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• during hyperinsulinemic-euglycemic clamps, mice show similar rates of glucose infusion and disposal but increased basal hepatic glucose production
• glucose production by primary hepatocytes is increased by about 50%
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• high-fat diet fed mice exhibit impaired insulin sensitivity
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• monounsaturated fatty acid content (C18:1) is increased in livers
• mice treated with the Scd1 inhibitor A939572 show normalization of monounsaturated fatty acid content in the liver
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neoplasm
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• spontaneous tumors arise in aging mice at the same rate as in wild-type controls
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