All Phenotypes Gt(ROSA)26Sor<tm1(Tbx1/GFP)Bem> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gt(ROSA)26Sor^{tm1(Tbx1/GFP)Bem}
targeted mutation 1, Bernice E Morrow
MGI:5551717

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^{tm1(Tbx1/GFP)Bem}/Gt(ROSA)26Sor⁺ Tg(Pax2-cre)1Akg/0	involves: 129 * C57BL/6 * SJL	MGI:5551751
cn2	Gt(ROSA)26Sor^{tm1(Tbx1/GFP)Bem}/Gt(ROSA)26Sor⁺ Tbx1^tm6(cre)Bld/Tbx1⁺	involves: 129 * C57BL/6 * SJL	MGI:5551752
cn3	Gt(ROSA)26Sor^{tm1(Tbx1/GFP)Bem}/Gt(ROSA)26Sor^{tm1(Tbx1/GFP)Bem} Tbx1^tm6(cre)Bld/Tbx1⁺	involves: 129 * C57BL/6 * SJL	MGI:5551753
cn4	Gt(ROSA)26Sor^{tm1(Tbx1/GFP)Bem}/Gt(ROSA)26Sor⁺ Foxg1^tm1(cre)Skm/Foxg1⁺	involves: 129P2/OlaHsd * C57BL/6 * SJL	MGI:5551750
cn5	Gt(ROSA)26Sor^{tm1(Tbx1/GFP)Bem}/Gt(ROSA)26Sor⁺ Tbx1^tm1Bld/Tbx1^tm6(cre)Bld	involves: 129S7/SvEvBrd * C57BL/6 * SJL	MGI:5551754
cn6	Gt(ROSA)26Sor^{tm1(Tbx1/GFP)Bem}/Gt(ROSA)26Sor^{tm1(Tbx1/GFP)Bem} Tbx1^tm1Bld/Tbx1^tm6(cre)Bld	involves: 129S7/SvEvBrd * C57BL/6 * SJL	MGI:5551755

Allelic Composition	Gt(ROSA)26Sor^{tm1(Tbx1/GFP)Bem}/Gt(ROSA)26Sor⁺ Tg(Pax2-cre)1Akg/0
Genetic Background	involves: 129 * C57BL/6 * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Thymic aplasia, nasal malformations, and eye, pharyngeal and ear defects in Gt(ROSA)26Sor^{tm1(Tbx1/GFP)Bem}/Gt(ROSA)26Sor⁺ Foxg1^tm1(cre)Skm/Foxg1⁺ mice and microcephaly, ocular and ear defects in Gt(ROSA)26Sor^{tm1(Tbx1/GFP)Bem}/Gt(ROSA)26Sor⁺ Tg(Pax2-cre)1Akg/0 mice

mortality/aging

perinatal lethality, complete penetrance ( J:204435 )

hearing/vestibular/ear

abnormal cochlea morphology ( J:204435 )

• hypoplastic to varying degrees, but enlarged in two instances

abnormal semicircular canal morphology ( J:204435 )

• fusion plates are not joined at E12.25

• however, they have partially recovered by E14.5

abnormal common crus morphology ( J:204435 )

• enlarged at E14.5

absent lateral semicircular canal ( J:204435 )

absent utricle ( J:204435 )

absent vestibular saccule ( J:204435 )

abnormal endolymphatic duct morphology ( J:204435 )

• enlarged at E14.5

Allelic Composition	Gt(ROSA)26Sor^{tm1(Tbx1/GFP)Bem}/Gt(ROSA)26Sor⁺ Tbx1^tm6(cre)Bld/Tbx1⁺
Genetic Background	involves: 129 * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm1(Tbx1/GFP)Bem} mutation (1 available); any Gt(ROSA)26Sor mutation (944 available)
Tbx1^tm6(cre)Bld mutation (1 available); any Tbx1 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:204435 )

N	• mice exhibit normal heart development at E14.5

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:204435 )

N	• mice do not exhibit any morphological defects in the inner ear

Allelic Composition	Gt(ROSA)26Sor^{tm1(Tbx1/GFP)Bem}/Gt(ROSA)26Sor^{tm1(Tbx1/GFP)Bem} Tbx1^tm6(cre)Bld/Tbx1⁺
Genetic Background	involves: 129 * C57BL/6 * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Heart development defects in Tbx1^tm6(cre)Bld/Tbx1⁺ Gt(ROSA)26Sor^{tm1(Tbx1/GFP)Bem}/Gt(ROSA)26Sor^{tm1(Tbx1/GFP)Bem} mice

mortality/aging

postnatal lethality, complete penetrance ( J:204435 )

• no mice are present at P10

cardiovascular system

persistent truncus arteriosus ( J:204435 )

• in 2 of 5 mice

double outlet right ventricle ( J:204435 )

• in 3 of 5 mice

ventricular septal defect ( J:204435 )

• in all mice

Allelic Composition	Gt(ROSA)26Sor^{tm1(Tbx1/GFP)Bem}/Gt(ROSA)26Sor⁺ Foxg1^tm1(cre)Skm/Foxg1⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxg1^tm1(cre)Skm mutation (2 available); any Foxg1 mutation (28 available)
Gt(ROSA)26Sor^{tm1(Tbx1/GFP)Bem} mutation (1 available); any Gt(ROSA)26Sor mutation (944 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:204435 )

hearing/vestibular/ear

abnormal cochlea morphology ( J:204435 )

• hypoplastic to varying degrees, but enlarged in two instances

abnormal common crus morphology ( J:204435 )

• enlarged at E14.5

absent lateral semicircular canal ( J:204435 )

absent utricle ( J:204435 )

absent vestibular saccule ( J:204435 )

abnormal endolymphatic duct morphology ( J:204435 )

• enlarged at E14.5

nervous system

abnormal forebrain morphology ( J:204435 )

cochlear ganglion degeneration ( J:204435 )

abnormal geniculate ganglion morphology ( J:204435 )

• abnormal size and misguided projections

abnormal glossopharyngeal ganglion morphology ( J:204435 )

• abnormal size and misguided projections

abnormal trigeminal ganglion morphology ( J:204435 )

• abnormal size and misguided projections

abnormal vagus ganglion morphology ( J:204435 )

• abnormal size and misguided projections

vestibular ganglion degeneration ( J:204435 )

respiratory system

abnormal nasal placode morphology ( J:204435 )

vision/eye

abnormal optic vesicle formation ( J:204435 )

hematopoietic system

athymia ( J:204435 )

• thymic aplasia

craniofacial

abnormal frontonasal prominence morphology ( J:204435 )

abnormal nasal placode morphology ( J:204435 )

taste/olfaction

abnormal nasal placode morphology ( J:204435 )

immune system

athymia ( J:204435 )

• thymic aplasia

endocrine/exocrine glands

athymia ( J:204435 )

• thymic aplasia

Allelic Composition	Gt(ROSA)26Sor^{tm1(Tbx1/GFP)Bem}/Gt(ROSA)26Sor⁺ Tbx1^tm1Bld/Tbx1^tm6(cre)Bld
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm1(Tbx1/GFP)Bem} mutation (1 available); any Gt(ROSA)26Sor mutation (944 available)
Tbx1^tm1Bld mutation (1 available); any Tbx1 mutation (34 available)
Tbx1^tm6(cre)Bld mutation (1 available); any Tbx1 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Failure of inner ear morphogenesis in Tbx1^tm1Bld/Tbx1^tm1Bld mice at E14.5 and partial rescue of inner ear morphogenesis in Tbx1^tm6(cre)Bld/Tbx1^tm1Bld Gt(ROSA)26Sor^{tm1(Tbx1/GFP)Bem}/ Gt(ROSA)26Sor⁺ mice

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:204435 )

N	• recovery of the anterior and posterior semicircular canals compared with null mice

abnormal cochlea morphology ( J:204435 )

• partial rescue with null mice

abnormal vestibular saccule morphology ( J:204435 )

• partial rescue with null mice

cardiovascular system

double outlet right ventricle ( J:204435 )

• in half of mice

ventricular septal defect ( J:204435 )

• in all mice

Allelic Composition	Gt(ROSA)26Sor^{tm1(Tbx1/GFP)Bem}/Gt(ROSA)26Sor^{tm1(Tbx1/GFP)Bem} Tbx1^tm1Bld/Tbx1^tm6(cre)Bld
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm1(Tbx1/GFP)Bem} mutation (1 available); any Gt(ROSA)26Sor mutation (944 available)
Tbx1^tm1Bld mutation (1 available); any Tbx1 mutation (34 available)
Tbx1^tm6(cre)Bld mutation (1 available); any Tbx1 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Gt(ROSA)26Sor^{tm1(Tbx1/GFP)Bem} can patially rescue heart phenotypes in Tbx1^tm6(cre)Bld/Tbx1^tm1Bld mice

cardiovascular system

persistent truncus arteriosus ( J:204435 )

• in 5 of 6 mice

double outlet right ventricle ( J:204435 )

• in 1 of 6 mice

ventricular septal defect ( J:204435 )

• in 5 of 6 mice

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