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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		P4hbtm1.1Geno
targeted mutation 1.1, Genoway
MGI:5504624
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		P4hbtm1.1Geno/P4hbtm1.1Geno
Tg(Pf4-icre)Q3Rsko/0 		involves: 129 * C57BL/6 MGI:6377675
cn2
 		P4hbtm1.1Geno/P4hbtm1.1Geno
Tg(Mx1-cre)1Cgn/0 		involves: 129 * C57BL/6 * C57BL/6J * CBA/J MGI:6377674
cn3
 		P4hbtm1.1Geno/P4hbtm1.2Geno
Lyz2tm1(cre)Ifo/Lyz2+ 		involves: 129P2/OlaHsd MGI:5504638


Genotype
MGI:6377675
cn1
Allelic
Composition		 P4hbtm1.1Geno/P4hbtm1.1Geno
Tg(Pf4-icre)Q3Rsko/0
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
P4hbtm1.1Geno mutation (0 available); any P4hb mutation (31 available)
Tg(Pf4-icre)Q3Rsko mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased platelet aggregation ( J:229395 )
• mice have a defect in platelet accumulation at sites of laser-induced cremaster arteriole injury
• thrombin- and convulxin-induced aggregation of platelets is decreased, however higher doses of thrombin or convulxin overcome the aggregation defect
abnormal platelet dense granule physiology ( J:229395 )
• ATP secretion from dense granules of platelets is about 50% of the normal platelets
decreased susceptibility to induced thrombosis ( J:229395 )
• the time to complete occlusion after FeCl3-induced injury of the carotid artery is doubled
• incorporation of platelets into a thrombus in a FeCL3-induced mesenteric artery thrombosis model is decreased
• however, platelets do not have a defect in fibrin deposition at sites of injury
increased bleeding time ( J:229395 )
• tail bleeding times are approximately doubled

hematopoietic system
hematopoietic system phenotype ( J:229395 )
N
• complete blood counts show no abnormalities and platelet counts and size are normal
decreased platelet aggregation ( J:229395 )
• mice have a defect in platelet accumulation at sites of laser-induced cremaster arteriole injury
• thrombin- and convulxin-induced aggregation of platelets is decreased, however higher doses of thrombin or convulxin overcome the aggregation defect
abnormal platelet dense granule physiology ( J:229395 )
• ATP secretion from dense granules of platelets is about 50% of the normal platelets




Genotype
MGI:6377674
cn2
Allelic
Composition		 P4hbtm1.1Geno/P4hbtm1.1Geno
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: 129 * C57BL/6 * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
P4hbtm1.1Geno mutation (0 available); any P4hb mutation (31 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased platelet aggregation ( J:229395 )
• poly(I:C)-treated mice show defects in platelet accumulation at sites of injury laser-induced cremaster arteriole injury
decreased susceptibility to induced thrombosis ( J:229395 )
• poly(I:C)-treated mice show defects in platelet accumulation and fibrin deposition at sites of laser-induced cremaster arteriole injury

hematopoietic system
hematopoietic system phenotype ( J:229395 )
N
• poly(I:C)-treated mice exhibit normal blood counts and platelet counts are comparable to controls although slightly lower after poly(I:C) and platelet size is comparable to controls
decreased platelet aggregation ( J:229395 )
• poly(I:C)-treated mice show defects in platelet accumulation at sites of injury laser-induced cremaster arteriole injury




Genotype
MGI:5504638
cn3
Allelic
Composition		 P4hbtm1.1Geno/P4hbtm1.2Geno
Lyz2tm1(cre)Ifo/Lyz2+
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyz2tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (41 available)
P4hbtm1.1Geno mutation (0 available); any P4hb mutation (31 available)
P4hbtm1.2Geno mutation (0 available); any P4hb mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased neutrophil cell number ( J:197556 )
• to the inflamed endothelium
impaired neutrophil recruitment ( J:197556 )
• during TNF-alpha-induced inflammation, mice exhibit increased rolling influx, reduced percentage of crawling cells among adherent neutrophils and reduced number of adherent neutrophils to the inflamed endothelium
• neutrophils exhibit reduced neutrophil adhesion to ICAM-1-coated surface compared with wild-type cells

hematopoietic system
decreased neutrophil cell number ( J:197556 )
• to the inflamed endothelium
impaired neutrophil recruitment ( J:197556 )
• during TNF-alpha-induced inflammation, mice exhibit increased rolling influx, reduced percentage of crawling cells among adherent neutrophils and reduced number of adherent neutrophils to the inflamed endothelium
• neutrophils exhibit reduced neutrophil adhesion to ICAM-1-coated surface compared with wild-type cells




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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory