Analysis Tools
normal phenotype
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• mice exhibit no phenotypic differences compared with wild-type mice
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Allele Symbol Allele Name Allele ID |
Gaktm2Legr targeted mutation 2, Lois E Greene MGI:5305733 |
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| Summary |
6 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice exhibit no phenotypic differences compared with wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mouse embryonic fibroblasts treated with a cre-expressing adenovirus exhibit altered clatherin-coated pits compared with control cells
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice die shortly after birth
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• at E17.5
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• the epidermis lacks extensive differentiation and multiple cell layers compared with control mice
• the epidermis exhibits reduced neutral lipids compared with control mice
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• underdeveloped
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• shortly after birth
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• shortly after birth
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• at E17.5
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• by P5
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• not well organized
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• hepatoblasts fail to differentiate
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• yellowish liver
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• mice fail to accumulate glycogen unlike control mice
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• small during the first 4 days after birth
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• at P1 or P2
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• mice fail to accumulate glycogen unlike control mice
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• not well organized
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice die between P3 and P21
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• mice exhibit decreased numbers of neuronal precursors due to reduced proliferation and migration compared with control mice
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• reduced
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• at E15.5, cellular density in the forebrain and hindbrain cortex is reduced compared to in control mice
• at P1, mice exhibit reduced cellularity and thickness of the cerebral cortex compared with control mice
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• decreased cell density
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• decreased cell density
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• due to reduced proliferation and migration
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• mice exhibit decreased numbers of neuronal precursors due to reduced proliferation and migration compared with control mice
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• reduced
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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