All Phenotypes Gdpd5<tm1Itl> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gdpd5^tm1Itl
targeted mutation 1, inGenious Targeting Laboratory
MGI:5302018

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gdpd5^tm1Itl/Gdpd5^tm1.1Itl Gt(ROSA)26Sor^{tm1(cre/ERT)Nat}/Gt(ROSA)26Sor⁺	involves: 129S1/Sv * 129/Sv * 129X1/SvJ * C57BL/6J	MGI:5302059

Allelic Composition	Gdpd5^tm1Itl/Gdpd5^tm1.1Itl Gt(ROSA)26Sor^{tm1(cre/ERT)Nat}/Gt(ROSA)26Sor⁺
Genetic Background	involves: 129S1/Sv * 129/Sv * 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gdpd5^tm1.1Itl mutation (0 available); any Gdpd5 mutation (37 available)
Gdpd5^tm1Itl mutation (0 available); any Gdpd5 mutation (37 available)
Gt(ROSA)26Sor^{tm1(cre/ERT)Nat} mutation (3 available); any Gt(ROSA)26Sor mutation (944 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:178550 )

N	• mice treated with tamoxifen after neurogenesis (at E10.5) exhibit normal motor pool formation

abnormal neuron differentiation ( J:178550 )

• mice treated with tamoxifen at E8.5 exhibit delayed motor neuron formation compared with control mice

decreased motor neuron number ( J:178550 )

• at E12.5, mice treated with tamoxifen at E8.5 exhibit fewer Isl1/2+ and vasti, adductor longus and magnus, and posterior gracilis muscle motor neurons compared with control mice

• at E14.5, mice treated with tamoxifen at E8.5 exhibit fewer Isl1/2+ and vasti muscle motor neurons compared with control mice

• however, motor neurons in adductor longus and magnus and posterior gracilis muscles recover by E14.5

cellular

abnormal neuron differentiation ( J:178550 )

• mice treated with tamoxifen at E8.5 exhibit delayed motor neuron formation compared with control mice

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