Gdpd5^tm1.1Itl
Targeted Allele Detail

Summary

• Symbol: Gdpd5^tm1.1Itl
• Name: glycerophosphodiester phosphodiesterase domain containing 5; targeted mutation 1.1, inGenious Targeting Laboratory
• MGI ID: MGI:5302017
• Synonyms: Gde2^-
• Gene: Gdpd5 Location: Chr7:99030621-99111084 bp, + strand Genetic Position: Chr7, 54.07 cM
• Alliance: Gdpd5^tm1.1Itl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:178550
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Cre-mediated recombination removed the neo cassette and exon 11. Western blot analysis confirmed the absence of protein expression in the E10.5 spinal cord. (J:178550)

Expression

In Mice Carrying this Mutation:

3 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gdpd5 Mutation: 37 strains or lines available

References

• Original: J:178550 Sabharwal P, et al., GDE2 regulates subtype-specific motor neuron generation through inhibition of Notch signaling. Neuron. 2011 Sep 22;71(6):1058-70
• All: 6 reference(s)