Phenotypes associated with this allele

• Allele Symbol: Mapk8ip2^tm1.1Gol
• Allele Name: targeted mutation 1.1, Mitchell Goldfarb
• Allele ID: MGI:4867721
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mapk8ip2^tm1.1Gol/Mapk8ip2^tm1.1Gol	129S/SvEv-Mapk8ip2^tm1.1Gol	MGI:4867727

Genotype
MGI:4867727

hm1

• Allelic Composition: Mapk8ip2^tm1.1Gol/Mapk8ip2^tm1.1Gol
• Genetic Background: 129S/SvEv-Mapk8ip2^tm1.1Gol

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reduced fertility ( J:166700 )

• mice are poor breeders possibly due to social deficit

nervous system

nervous system phenotype ( J:166700 )

N • mice exhibit normal molecular composition and ultrastructure of glutamatergic synapses

abnormal Purkinje cell morphology ( J:166700 )

• total dendritic intracellular volumes and surface area are decreased compared to in wild-type mice

abnormal Purkinje cell dendrite morphology ( J:166700 )

• dendrites are thinner and dendritic arbors shorter than in wild-type mice

• however, fiber projection through the molecular layer and varicosity decoration of dendrites are normal

thin cerebellar molecular layer ( J:166700 )

• in lobules 3 or 4

abnormal excitatory postsynaptic currents ( J:166700 )

• mossy fiber-granule cell synapses exhibit decreased minimal excitatory postsynaptic currents, increased coefficient of variation, and higher percentage of failures compared to in wild-type mice

reduced AMPA-mediated synaptic currents ( J:166700 )

• mice exhibit reduced AMPA-mediated synaptic currents in cerebellar mossy fiber to granule cells and climbing fiber to Purkinje cell synapses compared to in wild-type mice

enhanced NMDA-mediated synaptic currents ( J:166700 )

• in cerebellar mossy fiber to granule cell synapses

abnormal miniature excitatory postsynaptic currents ( J:166700 )

• smaller in mossy fiber-granule cell synapses

decreased synaptic glutamate release ( J:166700 )

• calculated quantal release probability and quantum size are smaller than in wild-type mice

• however, the number of release sites is normal

behavior/neurological

behavior/neurological phenotype ( J:166700 )

N • mice exhibit normal locomotion and balance on a narrow ledge

decreased exploration in new environment ( J:166700 )

decreased anxiety-related response ( J:166700 )

• on day 1 in an elevated T maze mice exhibit reduced anxiety compared with wild-type mice

• however, by day 3 mice exhibit normal anxiety in an elevated T maze

impaired coordination ( J:166700 )

• on a rotarod on day one and after 4 days of training

decreased grip strength ( J:166700 )

• in juvenile mice but not at 5 weeks of age

abnormal social investigation ( J:166700 )

• mice spend less time interacting with other mice compared with wild-type mice

taste/olfaction

taste/olfaction phenotype ( J:166700 )

N • mice do not exhibit olfaction impairment

vision/eye

vision/eye phenotype ( J:166700 )

N • mice do not exhibit serious visual impairment