All Phenotypes Fntb<tm1.1Mbrg> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Fntb^tm1.1Mbrg
targeted mutation 1.1, Martin O Bergo
MGI:4441481

Summary

9 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Fntb^tm1.1Mbrg/Fntb^tm1.1Mbrg	involves: 129P2/OlaHsd * C57BL/6	MGI:4441485
cn2	Fntb^tm1.1Mbrg/Fntb^tm1.2Mbrg	involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * FVB/N	MGI:4441484
cn3	Fntb^tm1.1Mbrg/Fntb^tm1.2Mbrg Kras^tm4Tyj/Kras⁺	involves: 129P2/OlaHsd * 129S4/SvJae * BALB/cJ * C57BL/6 * FVB/N	MGI:4441486
cn4	Fntb^tm1.1Mbrg/Fntb^tm1.2Mbrg Kras^tm4Tyj/Kras⁺ Pggt1b^tm1Mbrg/Pggt1b^tm1.1Mbrg Lyz2^tm1(cre)Ifo/Lyz2⁺	involves: 129P2/OlaHsd * 129S4/SvJae * BALB/cJ * C57BL/6 * FVB/N	MGI:4441488
cn5	Fntb^tm1.1Mbrg/Fntb^tm1.2Mbrg Kras^tm4Tyj/Kras⁺ Pggt1b^tm1Mbrg/Pggt1b^tm1.1Mbrg	involves: 129P2/OlaHsd * 129S4/SvJae * BALB/cJ * C57BL/6 * FVB/N	MGI:4441490
cn6	Fntb^tm1.1Mbrg/Fntb^tm1.2Mbrg Kras^tm4Tyj/Kras⁺ Lyz2^tm1(cre)Ifo/Lyz2⁺	involves: 129P2/OlaHsd * 129S4/SvJae * BALB/cJ * C57BL/6 * FVB/N	MGI:4441492
cn7	Fntb^tm1.1Mbrg/Fntb^tm1.1Mbrg Pggt1b^tm1Mbrg/Pggt1b^tm1Mbrg	involves: 129P2/OlaHsd * C57BL/6	MGI:4441487
cn8	Fntb^tm1.1Mbrg/Fntb^tm1.1Mbrg Tg(KRT14-cre)1Amc/?	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:4442842
cn9	Fntb^tm1.1Mbrg/Fntb^tm1.1Mbrg Pggt1b^tm1Mbrg/Pggt1b^tm1Mbrg Tg(KRT14-cre)1Amc/?	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:4442843

Allelic Composition	Fntb^tm1.1Mbrg/Fntb^tm1.1Mbrg
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fntb^tm1.1Mbrg mutation (0 available); any Fntb mutation (207 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal cell morphology ( J:158937 )

• following Cre-adenovirus treatment, embryonic fibroblasts are large and flat

abnormal cell cycle ( J:158937 )

• following Cre-adenovirus treatment, embryonic fibroblasts accumulate in the G2M phase of the cell cycle

decreased fibroblast proliferation ( J:158937 )

• reduced proliferation in primary embryonic fibroblasts, following Cre-adenovirus treatment

Allelic Composition	Fntb^tm1.1Mbrg/Fntb^tm1.2Mbrg
Genetic Background	involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * FVB/N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal cell morphology ( J:158937 )

• following Cre-adenovirus treatment, embryonic fibroblasts are large and flat

abnormal cell cycle ( J:158937 )

• following Cre-adenovirus treatment, embryonic fibroblasts accumulate in the G2M phase of the cell cycle

decreased fibroblast proliferation ( J:158937 )

• reduced proliferation in primary embryonic fibroblasts, following Cre-adenovirus treatment

Allelic Composition	Fntb^tm1.1Mbrg/Fntb^tm1.2Mbrg Kras^tm4Tyj/Kras⁺
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae * BALB/cJ * C57BL/6 * FVB/N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal cell cycle ( J:158937 )

• Cre-adenovirus treatment results in G2M cell-cycle arrest in embryonic fibroblasts

Allelic Composition	Fntb^tm1.1Mbrg/Fntb^tm1.2Mbrg Kras^tm4Tyj/Kras⁺ Pggt1b^tm1Mbrg/Pggt1b^tm1.1Mbrg Lyz2^tm1(cre)Ifo/Lyz2⁺
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae * BALB/cJ * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fntb^tm1.1Mbrg mutation (0 available); any Fntb mutation (207 available)
Fntb^tm1.2Mbrg mutation (0 available); any Fntb mutation (207 available)
Kras^tm4Tyj mutation (9 available); any Kras mutation (76 available)
Lyz2^tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (41 available)
Pggt1b^tm1.1Mbrg mutation (0 available); any Pggt1b mutation (25 available)
Pggt1b^tm1Mbrg mutation (0 available); any Pggt1b mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:158937 )

• median life span is 170 days

• longer median life span than Lyz2^tm1(cre)Ifo, Kras^tm4Tyj heterozygous mice (170 vs. 22 days)

neoplasm

decreased tumor growth/size ( J:158937 )

• lung weight and histology are indistinguishable from littermate control mice at 3-week old, compare with lung weight is 10-fold higher in Lyz2^tm1(cre)Ifo, Kras^tm4Tyj heterozygous mice

increased lung tumor incidence ( J:158937 )

• lung weight and histology are indistinguishable from littermate control mice at 3-week old

• but eventually develop lung tumors at older age

respiratory system

increased lung tumor incidence ( J:158937 )

• lung weight and histology are indistinguishable from littermate control mice at 3-week old

• but eventually develop lung tumors at older age

Allelic Composition	Fntb^tm1.1Mbrg/Fntb^tm1.2Mbrg Kras^tm4Tyj/Kras⁺ Pggt1b^tm1Mbrg/Pggt1b^tm1.1Mbrg
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae * BALB/cJ * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fntb^tm1.1Mbrg mutation (0 available); any Fntb mutation (207 available)
Fntb^tm1.2Mbrg mutation (0 available); any Fntb mutation (207 available)
Kras^tm4Tyj mutation (9 available); any Kras mutation (76 available)
Pggt1b^tm1.1Mbrg mutation (0 available); any Pggt1b mutation (25 available)
Pggt1b^tm1Mbrg mutation (0 available); any Pggt1b mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

decreased tumor growth/size ( J:158937 )

• 76% fewer tumors and 79% smaller lesion area than Kras^tm4Tyj heterozygous mice after Cre-adenovirus treatment

increased lung tumor incidence ( J:158937 )

• the lung surface of Cre-adenovirus treated mice is nearly indistinguishable from that of control mice

• 76% fewer tumors and 79% smaller lesion area than Kras^tm4Tyj heterozygous mice after Cre-adenovirus treatment

increased lung adenoma incidence ( J:158937 )

• presence of small adenomas after Cre-adenovirus treatment

increased lung carcinoma incidence ( J:158937 )

• adenocarcinoma in 1 of 11 mice after Cre-adenovirus treatment

respiratory system

increased lung tumor incidence ( J:158937 )

• the lung surface of Cre-adenovirus treated mice is nearly indistinguishable from that of control mice

• 76% fewer tumors and 79% smaller lesion area than Kras^tm4Tyj heterozygous mice after Cre-adenovirus treatment

increased lung adenoma incidence ( J:158937 )

• presence of small adenomas after Cre-adenovirus treatment

increased lung carcinoma incidence ( J:158937 )

• adenocarcinoma in 1 of 11 mice after Cre-adenovirus treatment

abnormal lung epithelium morphology ( J:158937 )

• presence of epithelial hyperplasia after Cre-adenovirus treatment

Allelic Composition	Fntb^tm1.1Mbrg/Fntb^tm1.2Mbrg Kras^tm4Tyj/Kras⁺ Lyz2^tm1(cre)Ifo/Lyz2⁺
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae * BALB/cJ * C57BL/6 * FVB/N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:158937 )

• longer life span than Lyz2^tm1(cre)Ifo, Kras^tm4Tyj heterozygous mice (>100 days in some cases)

respiratory system

increased lung weight ( J:158937 )

• lung weight is less than Lyz2^tm1(cre)Ifo, Kras^tm4Tyj heterozygous mice but higher than in normal mice

increased lung tumor incidence ( J:158937 )

neoplasm

decreased tumor growth/size ( J:158937 )

• lung weight is less than Lyz2^tm1(cre)Ifo, Kras^tm4Tyj heterozygous mice

increased lung tumor incidence ( J:158937 )

growth/size/body

increased lung weight ( J:158937 )

• lung weight is less than Lyz2^tm1(cre)Ifo, Kras^tm4Tyj heterozygous mice but higher than in normal mice

Allelic Composition	Fntb^tm1.1Mbrg/Fntb^tm1.1Mbrg Pggt1b^tm1Mbrg/Pggt1b^tm1Mbrg
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fntb^tm1.1Mbrg mutation (0 available); any Fntb mutation (207 available)
Pggt1b^tm1Mbrg mutation (0 available); any Pggt1b mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

increased fibroblast apoptosis ( J:158937 )

• Cre-adenovirus treatment results in apoptosis in embryonic fibroblasts within 4 days

• Cre-adenovirus treatment results in apoptosis in embryonic fibroblasts expressing oncogenic H-RAS in the plasma membrane

Allelic Composition	Fntb^tm1.1Mbrg/Fntb^tm1.1Mbrg Tg(KRT14-cre)1Amc/?
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fntb^tm1.1Mbrg mutation (0 available); any Fntb mutation (207 available)
Tg(KRT14-cre)1Amc mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body size ( J:158528 )

• most of the hair shafts are dysmorphic

• all of the layers of the shaft develop but the shafts are smaller and not as straight as in controls

integument

increased hair follicle apoptosis ( J:158528 )

• apoptotic cells are detected in the hair follicle at P1 and are even more numerous at P4, P6 and P8

• scattered apoptotic cells are detected in the interfollicular epidermis at P4, P6 and P8

decreased keratinocyte proliferation ( J:158528 )

• marked proliferation defect in culture cells

alopecia ( J:158528 )

• by P6 alopecia is virtually complete and persists throughout life

abnormal hair shaft morphology ( J:158528 )

underdeveloped hair follicles ( J:158528 )

• hair follicles are stunted in appearance

• hair follicles appear normal at E17.5 but stunting of hair follicles is easily apparent at all post-natal time points

abnormal hair follicle orientation ( J:158528 )

• most of the hair shafts are improperly angled and few penetrated the surface of the skin

decreased hair follicle number ( J:158528 )

• hair follicles have largely disappeared by P120

abnormal keratinocyte morphology ( J:158528 )

• keratinocytes in culture have a flattened morphology

cellular

increased hair follicle apoptosis ( J:158528 )

• apoptotic cells are detected in the hair follicle at P1 and are even more numerous at P4, P6 and P8

• scattered apoptotic cells are detected in the interfollicular epidermis at P4, P6 and P8

decreased keratinocyte proliferation ( J:158528 )

• marked proliferation defect in culture cells

Allelic Composition	Fntb^tm1.1Mbrg/Fntb^tm1.1Mbrg Pggt1b^tm1Mbrg/Pggt1b^tm1Mbrg Tg(KRT14-cre)1Amc/?
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CBA

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

decreased hair follicle number ( J:158528 )

• at E17.5 embryos have fewer hair follicles

thin epidermis ( J:158528 )

• interfollicular epidermis is slightly thinner compared to either single mutant at E17.5

abnormal skin physiology ( J:158528 )

• at E17.5 more apoptotic cells are present than in either single mutant

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