All Phenotypes Il10ra<tm1.1Jack> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Scn10a^tm2(cre)Jwo/Scn10a⁺ Il10ra^tm1.1Jack/Il10ra^tm1.1Jack	involves: 129P2/OlaHsd	MGI:7334745
cn2	Il10ra^tm1.1Jack/Il10ra^tm1.1Jack Lyz2^tm1(cre)Ifo/Lyz2⁺	involves: 129P2/OlaHsd * BALB/c * C57BL/6	MGI:4437328
cn3	Cd19^tm1(cre)Cgn/Cd19⁺ Il10ra^tm1.1Jack/Il10ra^tm1.1Jack	involves: 129P2/OlaHsd * BALB/c * C57BL/6	MGI:4437331
cn4	Il10ra^tm1.1Jack/Il10ra^tm1.1Jack Tg(Cd4-cre)1Cwi/0	involves: 129P2/OlaHsd * BALB/c * C57BL/6 * DBA/2	MGI:4437330

Allelic Composition	Scn10a^tm2(cre)Jwo/Scn10a⁺ Il10ra^tm1.1Jack/Il10ra^tm1.1Jack
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il10ra^tm1.1Jack mutation (1 available); any Il10ra mutation (32 available)
Scn10a^tm2(cre)Jwo mutation (3 available); any Scn10a mutation (102 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:326965 )

N	• mice exhibit normal recovery from carrageenan-induced inflammatory hyperalgesia

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal cytokine level ( J:157787 )

• in LPS-injected mice

increased circulating interferon-gamma level ( J:157787 )

• in LPS-injected mice compared with similarly treated wild-type mice

increased circulating interleukin-1 alpha level ( J:157787 )

• in LPS-injected mice

increased circulating interleukin-1 beta level ( J:157787 )

• in LPS-injected mice

increased circulating interleukin-12 level ( J:157787 )

• in LPS-injected mice compared with similarly treated Il10ra^tm1.1Jack homozygotes

increased circulating interleukin-17 level ( J:157787 )

• in LPS-injected mice

increased circulating interleukin-2 level ( J:157787 )

• in LPS-injected mice

increased circulating tumor necrosis factor level ( J:157787 )

• in LPS-injected mice compared with similarly treated Il10ra^tm1.1Jack homozygotes

abnormal chemokine level ( J:157787 )

• LPS-injected mice exhibit increased CXCL10 and CXCL1 levels compared with similarly treated wild-type mice

increased susceptibility to parasitic infection ( J:157787 )

• mice infected with T. muris exhibit increased cecum score compared with similarly treated wild-type mice

homeostasis/metabolism

abnormal cytokine level ( J:157787 )

• in LPS-injected mice

increased circulating interferon-gamma level ( J:157787 )

• in LPS-injected mice compared with similarly treated wild-type mice

increased circulating interleukin-1 alpha level ( J:157787 )

• in LPS-injected mice

increased circulating interleukin-1 beta level ( J:157787 )

• in LPS-injected mice

increased circulating interleukin-12 level ( J:157787 )

• in LPS-injected mice compared with similarly treated Il10ra^tm1.1Jack homozygotes

increased circulating interleukin-17 level ( J:157787 )

• in LPS-injected mice

increased circulating interleukin-2 level ( J:157787 )

• in LPS-injected mice

increased circulating tumor necrosis factor level ( J:157787 )

• in LPS-injected mice compared with similarly treated Il10ra^tm1.1Jack homozygotes

abnormal chemokine level ( J:157787 )

• LPS-injected mice exhibit increased CXCL10 and CXCL1 levels compared with similarly treated wild-type mice

Allelic Composition	Cd19^tm1(cre)Cgn/Cd19⁺ Il10ra^tm1.1Jack/Il10ra^tm1.1Jack
Genetic Background	involves: 129P2/OlaHsd * BALB/c * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19^tm1(cre)Cgn mutation (11 available); any Cd19 mutation (56 available)
Il10ra^tm1.1Jack mutation (1 available); any Il10ra mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:157787 )

N	• mice exhibit a normal response to LPS injection and T. muris infection

Allelic Composition	Il10ra^tm1.1Jack/Il10ra^tm1.1Jack Tg(Cd4-cre)1Cwi/0
Genetic Background	involves: 129P2/OlaHsd * BALB/c * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il10ra^tm1.1Jack mutation (1 available); any Il10ra mutation (32 available)
Tg(Cd4-cre)1Cwi mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:157787 )

N	• mice exhibit a normal response to LPS injection and T. muris infection

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