About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ezh2tm1Yugo
targeted mutation 1, Yukiko Gotoh
MGI:4412411
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Ezh2tm1Yugo/Ezh2tm1Yugo
Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+ 		involves: 129S/Sv * C57BL/6 MGI:4413346
cn2
 		Ezh2tm1Yugo/Ezh2tm1Yugo
Tg(Nes-cre/ERT2)5-1Imayo/0 		involves: C57BL/6 MGI:4413347


Genotype
MGI:4413346
cn1
Allelic
Composition		 Ezh2tm1Yugo/Ezh2tm1Yugo
Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129S/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ezh2tm1Yugo mutation (1 available); any Ezh2 mutation (71 available)
Gt(ROSA)26Sortm9(cre/ESR1)Arte mutation (2 available); any Gt(ROSA)26Sor mutation (944 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal neuron differentiation ( J:154927 )
• following exposure to tamoxifen, neuronal differentiation in culture induced by FGF2 deprivation or S33Y beta-catenin expression is enhanced compared to in similarly treated control mice
• following exposure to tamoxifen, the reduction in Ngn1+ cells in the late neurogenic phase (E17.5) is suppressed compared to in similarly treated control mice

cellular
abnormal neuron differentiation ( J:154927 )
• following exposure to tamoxifen, neuronal differentiation in culture induced by FGF2 deprivation or S33Y beta-catenin expression is enhanced compared to in similarly treated control mice
• following exposure to tamoxifen, the reduction in Ngn1+ cells in the late neurogenic phase (E17.5) is suppressed compared to in similarly treated control mice




Genotype
MGI:4413347
cn2
Allelic
Composition		 Ezh2tm1Yugo/Ezh2tm1Yugo
Tg(Nes-cre/ERT2)5-1Imayo/0
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ezh2tm1Yugo mutation (1 available); any Ezh2 mutation (71 available)
Tg(Nes-cre/ERT2)5-1Imayo mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal neuron differentiation ( J:154927 )
• following tamoxifen treatment at E13.5 and E14.5, the number of S100beta+ cells are reduced in the neocortex at P1.5 compared to in similarly treated control mice

cellular
abnormal neuron differentiation ( J:154927 )
• following tamoxifen treatment at E13.5 and E14.5, the number of S100beta+ cells are reduced in the neocortex at P1.5 compared to in similarly treated control mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory