Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plxnd1tm1.1Tmj mutation
(1 available);
any
Plxnd1 mutation
(86 available)
Tg(CAG-cre/Esr1*)5Amc mutation
(9 available)
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cardiovascular system
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• tamoxifen-treated retinas exhibit reduced angiogenesis and hemorrhages compared to in wild-type mice
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• tamoxifen-treated retinas exhibit reduced angiogenesis compared to in wild-type mice
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• vascular invasion of tamoxifen-treated endothelial cells into matrigel plugs treated with endothelial cell growth factor is deficient compared to that of wild-type cells
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• tamoxifen-treated retinas exhibit hemorrhages unlike wild-type retinas
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vision/eye
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• tamoxifen-treated retinas exhibit reduced angiogenesis and hemorrhages compared to in wild-type mice
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cellular
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• vascular invasion of tamoxifen-treated endothelial cells into matrigel plugs treated with endothelial cell growth factor is deficient compared to that of wild-type cells
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mortality/aging
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N |
• normal numbers of mice are born
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cardiovascular system
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N |
• mice exhibit normal cardiac development with normal outflow tract septation
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plxnd1tm1.1Tmj mutation
(1 available);
any
Plxnd1 mutation
(86 available)
Tg(Tek-cre)1Ywa mutation
(6 available)
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mortality/aging
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• all but 1 mouse died by P2
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cardiovascular system
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• mice exhibit abnormal microvasculature within bones
• however, large vessels attached to the long bones appear intact
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• the root of the aorta is located more distally from the ascending portion of the truncus arteriosis or from the ascending aorta than in wild-type mice
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• at E11.5, mice exhibit poor remodeling of the vascular plexus of the immature intersomitic vessels unlike in wild-type mice
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• mice exhibit abnormally condensed discontinuous atrial myocardial architecture unlike in wild-type mice
• the atrial myocardium is separated from the epicardium unlike in wild-type mice
• the ventricular myocardial wall is abnormal and unusual epicardial blood islands unlike in wild-type mice
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• the outflow tract is malrotated compared to in wild-type mice
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• at E12.5, mice exhibit coronary vessel defects
• originate more distally from the ascending portion of the truncus arteriosus, or from the ascending aorta (when partial or compete septation was present) in all mutant hearts examined (N=5)
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• the atria appear raspberry-like
• mice exhibit abnormally condensed discontinuous atrial myocardial architecture unlike in wild-type mice
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• the atrial myocardium is separated from the epicardium unlike in wild-type mice
• the ventricular myocardial wall is abnormal and unusual epicardial blood islands are present unlike in wild-type mice
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• mice exhibit subcutaneous hemorrhage, especially in the head, unlike in wild-type mice
• small hemorrhages are observed in the ventricular walls unlike in wild-type mice
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skeleton
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• poorly formed and frequently fused or split in the lumbar and thoracic regions
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• frequently fused in the lumbar and thoracic regions
• in the one mouse that survives into adulthood, vertebral bodies are fused along the entire anterior-posterior axis
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nervous system
homeostasis/metabolism
growth/size/body
limbs/digits/tail
muscle
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• mice exhibit abnormally condensed discontinuous atrial myocardial architecture unlike in wild-type mice
• the atrial myocardium is separated from the epicardium unlike in wild-type mice
• the ventricular myocardial wall is abnormal and unusual epicardial blood islands unlike in wild-type mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2Tg(Wnt1-cre)11Rth mutation
(2 available);
any
H2az2 mutation
(26 available)
Plxnd1tm1.1Tmj mutation
(1 available);
any
Plxnd1 mutation
(86 available)
Plxnd1tm1Ddg mutation
(0 available);
any
Plxnd1 mutation
(86 available)
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nervous system
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• mice exhibit a 3-fold increase in the number of proprioceptive synaptic contacts with identified cutaneous maximus motor neurons compared to in wild-type mice
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• 43% of cutaneous motor neurons receive monosynaptic input after stimulation of cutaneous maximus afferents unlike wild-type motor neurons
• however, monosynaptic specificity from the tricep is normal
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behavior/neurological
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N |
• mice exhibit no behavior deficits
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plxnd1tm1.1Tmj mutation
(1 available);
any
Plxnd1 mutation
(86 available)
Plxnd1tm1Ddg mutation
(0 available);
any
Plxnd1 mutation
(86 available)
Tg(CAG-cre/Esr1*)1Egwa mutation
(0 available)
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Increase in extraretinal vascular outgrowth in ischemic Plxnd1tm1.1Tmj/Plxnd1tm1Ddg Tg(CAG-cre/Esr1*)1Egwa/0 retinas
vision/eye
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• tamoxifen-treated mice exhibit increased extraretinal vascular outgrowth in ischemic retinas compared with control mice
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cardiovascular system
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• tamoxifen-treated mice exhibit increased extraretinal vascular outgrowth in ischemic retinas compared with control mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2Tg(Wnt1-cre)11Rth mutation
(2 available);
any
H2az2 mutation
(26 available)
Plxnd1tm1.1Tmj mutation
(1 available);
any
Plxnd1 mutation
(86 available)
Plxnd1tm1Ddg mutation
(0 available);
any
Plxnd1 mutation
(86 available)
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nervous system
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N |
• the patterns of hamstring knee flexor muscle and gluteus homonymous monosynaptic sensory-motor connections are similar to controls
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• a large amplitude of monosynaptic EPSP is seen in 45% of gluteus motor neurons unlike in controls
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plxnd1tm1.1Tmj mutation
(1 available);
any
Plxnd1 mutation
(86 available)
Tg(Nes-cre)1Atp mutation
(0 available)
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vision/eye
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N |
• mice exhibit normal retinal stratification
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Analysis Tools