Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(cre/ERT2)Thl mutation
(0 available);
any
Gt(ROSA)26Sor mutation
(944 available)
Zfxtm1.1Reiz mutation
(0 available);
any
Zfx mutation
(33 available)
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hematopoietic system
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• as early as 4 days after tamoxifen-induction
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• following tamoxifen treatment, the number of hematopoietic stem cell-containing LSK populations is decreased compared to in similarly treated wild-type mice
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• following tamoxifen treatment, maintenance of adult hematopoietic cells is abolished compared to in similarly treated wild-type mice
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Meox2tm1(cre)Sor mutation
(3 available);
any
Meox2 mutation
(18 available)
Zfxtm1.1Reiz mutation
(0 available);
any
Zfx mutation
(33 available)
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mortality/aging
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• mice die shortly after birth
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Meox2tm1(cre)Sor mutation
(3 available);
any
Meox2 mutation
(18 available)
Zfxtm1.1Reiz mutation
(0 available);
any
Zfx mutation
(33 available)
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mortality/aging
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• mice die shortly after birth
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Tek-cre)12Flv mutation
(1 available)
Zfxtm1.1Reiz mutation
(0 available);
any
Zfx mutation
(33 available)
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hematopoietic system
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• mature T cells are decreased compared to in wild-type mice
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• mice exhibit a reduction in hematopoietic stem cells and specifically self-renewing long-term hematopoietic stem cells compared to in wild-type mice
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• maintenance of adult hematopoietic cells is abolished compared to in wild-type mice
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immune system
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• mature T cells are decreased compared to in wild-type mice
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Mx1-cre)1Cgn mutation
(7 available)
Zfxtm1.1Reiz mutation
(0 available);
any
Zfx mutation
(33 available)
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hematopoietic system
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• pIpC-treated bone marrow cells fails to contribute to hematopoiesis in a competitively reconstituted bone marrow recipient unlike wild-type cells
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• following pIpC treatment, mice exhibit a reduction in lymphoid progenitor cells compared with wild-type mice
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• pIpC induction, lymphocyte are depleted and fail to regenerate unlike in similarly treated wild-type mice
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• 2 weeks after pIpC induction, the number of hematopoietic stem cell-containing LSK populations is decreased compared to in similarly treated wild-type mice
• following pIpC treatment, mice exhibit a reduction in hematopoietic stem cells, specifically self-renewing long-term and short-term hematopoietic stem cells and lymphoid progenitor cells, compared with wild-type mice
• however, proliferation of pIpC-treated erythroid-myeloid progenitor cells is normal
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• following pIpC treatment, hematopoietic stem cell apoptosis is increased compared to in similarly treated wild-type mice
• following pIpC treatment, maintenance of adult hematopoietic cells is abolished compared to in similarly treated wild-type mice
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immune system
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• pIpC induction, lymphocyte are depleted and fail to regenerate unlike in similarly treated wild-type mice
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Nes-cre)1Kln mutation
(4 available)
Zfxtm1.1Reiz mutation
(0 available);
any
Zfx mutation
(33 available)
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mortality/aging
N |
• mice survive into adulthood
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nervous system
N |
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Nes-cre)1Kln mutation
(4 available)
Zfxtm1.1Reiz mutation
(0 available);
any
Zfx mutation
(33 available)
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mortality/aging
N |
• mice survive into adulthood
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nervous system
N |
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