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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Gfap-cre)77.6Mvs
transgene insertion 77.6, Michael V Sofroniew
MGI:3838840
Summary 8 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Chrna7tm1.1Ehs/Chrna7tm1.1Ehs
Tg(Gfap-cre)77.6Mvs/0
B6.Cg-Chrna7tm1.1Ehs Tg(Gfap-cre)77.6Mvs MGI:5620296
cn2
Krastm4Tyj/Kras+
Tg(Gfap-cre)77.6Mvs/0
involves: 129 * BALB/c * C57BL/6NHsd MGI:4849444
cn3
Nf1tm1Par/Nf1+
Ptentm1Hwu/Pten+
Tg(Gfap-cre)77.6Mvs/0
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/c * C57BL/6NHsd MGI:4849443
cn4
Nf1tm1Par/Nf1tm1Par
Tg(Gfap-cre)77.6Mvs/0
involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6NHsd MGI:4849442
cn5
Krastm4Tyj/Kras+
Ptentm1Hwu/Pten+
Tg(Gfap-cre)77.6Mvs/0
involves: 129S4/SvJae * BALB/c * C57BL/6NHsd MGI:4849441
cn6
Ptentm1Hwu/Ptentm1Hwu
Tg(Gfap-cre)77.6Mvs/0
involves: 129S4/SvJae * BALB/c * C57BL/6NHsd MGI:3838843
cn7
Prrc2atm1Fcw/Prrc2atm1Fcw
Tg(Gfap-cre)77.6Mvs/0
involves: BALB/c * C57BL/6NHsd MGI:6724443
cn8
Acsl6tm1Jeme/Acsl6tm1Jeme
Tg(Gfap-cre)77.6Mvs/0
involves: BALB/cJ * C57BL/6 MGI:6269169


Genotype
MGI:5620296
cn1
Allelic
Composition
Chrna7tm1.1Ehs/Chrna7tm1.1Ehs
Tg(Gfap-cre)77.6Mvs/0
Genetic
Background
B6.Cg-Chrna7tm1.1Ehs Tg(Gfap-cre)77.6Mvs
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chrna7tm1.1Ehs mutation (1 available); any Chrna7 mutation (34 available)
Tg(Gfap-cre)77.6Mvs mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• mice are viable and fertile and exhibit no altered behavioral, cognitive, or electrophysiological properties




Genotype
MGI:4849444
cn2
Allelic
Composition
Krastm4Tyj/Kras+
Tg(Gfap-cre)77.6Mvs/0
Genetic
Background
involves: 129 * BALB/c * C57BL/6NHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm4Tyj mutation (9 available); any Kras mutation (55 available)
Tg(Gfap-cre)77.6Mvs mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
N
• mutants do not develop tumors




Genotype
MGI:4849443
cn3
Allelic
Composition
Nf1tm1Par/Nf1+
Ptentm1Hwu/Pten+
Tg(Gfap-cre)77.6Mvs/0
Genetic
Background
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/c * C57BL/6NHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nf1tm1Par mutation (4 available); any Nf1 mutation (111 available)
Ptentm1Hwu mutation (16 available); any Pten mutation (78 available)
Tg(Gfap-cre)77.6Mvs mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
N
• mutants do not develop tumors




Genotype
MGI:4849442
cn4
Allelic
Composition
Nf1tm1Par/Nf1tm1Par
Tg(Gfap-cre)77.6Mvs/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6NHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nf1tm1Par mutation (4 available); any Nf1 mutation (111 available)
Tg(Gfap-cre)77.6Mvs mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
N
• mutants do not develop tumors




Genotype
MGI:4849441
cn5
Allelic
Composition
Krastm4Tyj/Kras+
Ptentm1Hwu/Pten+
Tg(Gfap-cre)77.6Mvs/0
Genetic
Background
involves: 129S4/SvJae * BALB/c * C57BL/6NHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm4Tyj mutation (9 available); any Kras mutation (55 available)
Ptentm1Hwu mutation (16 available); any Pten mutation (78 available)
Tg(Gfap-cre)77.6Mvs mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• each mutant has more than one lesion with features of human neurofibroma and malignant peripheral nerve sheath tumor
• progressive development of malignant peripheral nerve sheath tumors (MPNST) from neurofibroma, with 100% of mutants showing MPNST when followed for 7 months
• Pten loss of heterozygosity in mutants correlates with MPNST transformation from neurofibromas

mortality/aging
• survival is on average 22 weeks

neoplasm
• mutants develop multiple visible subcutaneous tumors with 100% penetrance, starting from 4 months of age
• majority of tumors are located on the back and sides
• each mutant has more than one lesion with features of human neurofibroma and malignant peripheral nerve sheath tumor
• progressive development of malignant peripheral nerve sheath tumors (MPNST) from neurofibroma, with 100% of mutants showing MPNST when followed for 7 months
• Pten loss of heterozygosity in mutants correlates with MPNST transformation from neurofibromas

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
neurofibromatosis DOID:8712 J:154673




Genotype
MGI:3838843
cn6
Allelic
Composition
Ptentm1Hwu/Ptentm1Hwu
Tg(Gfap-cre)77.6Mvs/0
Genetic
Background
involves: 129S4/SvJae * BALB/c * C57BL/6NHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm1Hwu mutation (16 available); any Pten mutation (78 available)
Tg(Gfap-cre)77.6Mvs mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• cultured adult neural stem cells maintain their ability to differentiate into neurons for a longer time compared to wild-type cells
• in culture, neurospheres formed by adult neural stem cells are generally larger and the stem cells' capacity for self renewal is prolonged compared to wild-type cells
• 7 days after induction of limited stroke in the sensorimotor cortex, mice have more neuroblasts in the peri-infarct cortex compared to controls
• however, there is no difference in the number of new cells present at 90 days after stroke induction
• continuous increase in the weight and size of the olfactory bulb compared to controls starting at 2.5 months of age
• the granule cell layer volume is increased 2 fold at 3.5 months of age
• the increase in volume is due to an increase in the number of cells migrating from the subependymal zone to the olfactory bulb and a decrease in the number of apoptotic cells in the granule cell layer
• increase in the volume of the subependymal zone compared to controls
• increase in the number of proliferating cells and DCX positive neuroblasts
• expansion of the adult neural stem cell and progenitor populations in the subependymal zone

behavior/neurological
• habituate faster to a novel odorant compared to controls
• however, no difference in response is seen on the first exposure to a novel odorant

taste/olfaction
• mice recover olfactory ability more quickly following exposure to dichlobenil compared to controls

neoplasm
N
• in contrast to other conditional null Pten genotypes no tumors are found in mice up to 2 years of age (J:146630)
(J:154673)

homeostasis/metabolism
• 7 days after induction of limited stroke in the sensorimotor cortex, mice have more neuroblasts in the peri-infarct cortex compared to controls
• however, there is no difference in the number of new cells present at 90 days after stroke induction

cellular
• cultured adult neural stem cells maintain their ability to differentiate into neurons for a longer time compared to wild-type cells
• in culture, neurospheres formed by adult neural stem cells are generally larger and the stem cells' capacity for self renewal is prolonged compared to wild-type cells




Genotype
MGI:6724443
cn7
Allelic
Composition
Prrc2atm1Fcw/Prrc2atm1Fcw
Tg(Gfap-cre)77.6Mvs/0
Genetic
Background
involves: BALB/c * C57BL/6NHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prrc2atm1Fcw mutation (0 available); any Prrc2a mutation (48 available)
Tg(Gfap-cre)77.6Mvs mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• mice exhibit normal myelination and oligodendrocyte and astrocyte populations




Genotype
MGI:6269169
cn8
Allelic
Composition
Acsl6tm1Jeme/Acsl6tm1Jeme
Tg(Gfap-cre)77.6Mvs/0
Genetic
Background
involves: BALB/cJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acsl6tm1Jeme mutation (0 available); any Acsl6 mutation (28 available)
Tg(Gfap-cre)77.6Mvs mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• decreased omega-3 docosahexaenoic acid (DHA) levels in brain
• decreased omega-6 Arachidonate-containing phospholipids level in brain
• 57% decreased Acyl-CoA synthetase (ACS) in cerebellum





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/18/2022
MGI 6.17
The Jackson Laboratory