Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chrna7tm1.1Ehs mutation
(1 available);
any
Chrna7 mutation
(49 available)
Tg(Gfap-cre)77.6Mvs mutation
(1 available)
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normal phenotype
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• mice are viable and fertile and exhibit no altered behavioral, cognitive, or electrophysiological properties
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm4Tyj mutation
(9 available);
any
Kras mutation
(76 available)
Tg(Gfap-cre)77.6Mvs mutation
(1 available)
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neoplasm
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N |
• mutants do not develop tumors
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neoplasm
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N |
• mutants do not develop tumors
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neoplasm
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N |
• mutants do not develop tumors
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm1Hwu mutation
(16 available);
any
Pten mutation
(81 available)
Tg(Gfap-cre)77.6Mvs mutation
(1 available)
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nervous system
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• cultured adult neural stem cells maintain their ability to differentiate into neurons for a longer time compared to wild-type cells
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• in culture, neurospheres formed by adult neural stem cells are generally larger and the stem cells' capacity for self renewal is prolonged compared to wild-type cells
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• 7 days after induction of limited stroke in the sensorimotor cortex, mice have more neuroblasts in the peri-infarct cortex compared to controls
• however, there is no difference in the number of new cells present at 90 days after stroke induction
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• continuous increase in the weight and size of the olfactory bulb compared to controls starting at 2.5 months of age
• the granule cell layer volume is increased 2 fold at 3.5 months of age
• the increase in volume is due to an increase in the number of cells migrating from the subependymal zone to the olfactory bulb and a decrease in the number of apoptotic cells in the granule cell layer
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• increase in the volume of the subependymal zone compared to controls
• increase in the number of proliferating cells and DCX positive neuroblasts
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• expansion of the adult neural stem cell and progenitor populations in the subependymal zone
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behavior/neurological
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• habituate faster to a novel odorant compared to controls
• however, no difference in response is seen on the first exposure to a novel odorant
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taste/olfaction
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• mice recover olfactory ability more quickly following exposure to dichlobenil compared to controls
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neoplasm
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N |
• in contrast to other conditional null Pten genotypes no tumors are found in mice up to 2 years of age
(J:146630)
(J:154673)
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homeostasis/metabolism
cellular
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• cultured adult neural stem cells maintain their ability to differentiate into neurons for a longer time compared to wild-type cells
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• in culture, neurospheres formed by adult neural stem cells are generally larger and the stem cells' capacity for self renewal is prolonged compared to wild-type cells
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mortality/aging
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• survival is on average 22 weeks
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neoplasm
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• mutants develop multiple visible subcutaneous tumors with 100% penetrance, starting from 4 months of age
• majority of tumors are located on the back and sides
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• each mutant has more than one lesion with features of human neurofibroma and malignant peripheral nerve sheath tumor
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• progressive development of malignant peripheral nerve sheath tumors (MPNST) from neurofibroma, with 100% of mutants showing MPNST when followed for 7 months
• Pten loss of heterozygosity in mutants correlates with MPNST transformation from neurofibromas
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nervous system
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• each mutant has more than one lesion with features of human neurofibroma and malignant peripheral nerve sheath tumor
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• progressive development of malignant peripheral nerve sheath tumors (MPNST) from neurofibroma, with 100% of mutants showing MPNST when followed for 7 months
• Pten loss of heterozygosity in mutants correlates with MPNST transformation from neurofibromas
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prrc2atm1Fcw mutation
(0 available);
any
Prrc2a mutation
(62 available)
Tg(Gfap-cre)77.6Mvs mutation
(1 available)
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nervous system
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N |
• mice exhibit normal myelination and oligodendrocyte and astrocyte populations
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acsl6tm1Jeme mutation
(0 available);
any
Acsl6 mutation
(46 available)
Tg(Gfap-cre)77.6Mvs mutation
(1 available)
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Analysis Tools
