All Phenotypes Lig4<tm1Pmc> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Lig4^tm1Pmc
targeted mutation 1, Peter J McKinnon
MGI:3831168

Summary

9 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Lig4^tm1Pmc/Lig4^tm1Pmc Trp53^tm1Tyj/Trp53^tm1Tyj Tg(Nes-cre)1Kln/0	involves: 129S1/Sv * 129S2/SvPas * C57BL/6 * SJL	MGI:3831348
cn2	Lig4^tm1Pmc/Lig4^tm1Pmc Trp53^tm1Tyj/Trp53^tm1Tyj Xrcc2^tm2Pmc/Xrcc2^tm2Pmc Tg(Nes-cre)1Kln/0	involves: 129S1/Sv * 129S2/SvPas * C57BL/6 * SJL	MGI:3831351
cn3	Lig4^tm1Pmc/Lig4^tm1Pmc Trp53^tm1Tyj/Trp53⁺ Xrcc2^tm2Pmc/Xrcc2^tm2Pmc Tg(Nes-cre)1Kln/0	involves: 129S1/Sv * 129S2/SvPas * C57BL/6 * SJL	MGI:3831355
cn4	Lig4^tm1Pmc/Lig4^tm1Pmc Meox2^tm1(cre)Sor/Meox2⁺	involves: 129S1/Sv * 129S4/SvJaeSor	MGI:3831349
cn5	Lig4^tm1Pmc/Lig4^tm1Pmc Tg(Nes-cre)1Kln/0	involves: 129S1/Sv * C57BL/6 * SJL	MGI:3831346
cn6	Lig4^tm1Pmc/Lig4^tm1Pmc Mre11a^tm1Jpt/Mre11a^tm1Jpt Tg(Nes-cre)1Kln/0	involves: 129S1/SvImJ * 129S7/SvEvBrd * C57BL/6 * SJL	MGI:3831179
cn7	Lig4^tm1Pmc/Lig4^tm1Pmc Nbn^tm1Jpt/Nbn^tm1Jpt Tg(Nes-cre)1Kln/0	involves: 129S1/SvImJ * 129S7/SvEvBrd * C57BL/6 * SJL	MGI:3831185
cn8	Lig4^tm1Pmc/Lig4^tm1Pmc Tg(Nes-cre)1Kln/0	involves: 129S1/SvImJ * C57BL/6 * SJL	MGI:3831178
cn9	Atm^tm1Pmc/Atm^tm1Pmc Lig4^tm1Pmc/Lig4^tm1Pmc Tg(Nes-cre)1Kln/0	involves: 129S1/SvImJ * C57BL/6 * SJL	MGI:3831182

Allelic Composition	Lig4^tm1Pmc/Lig4^tm1Pmc Trp53^tm1Tyj/Trp53^tm1Tyj Tg(Nes-cre)1Kln/0
Genetic Background	involves: 129S1/Sv * 129S2/SvPas * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lig4^tm1Pmc mutation (0 available); any Lig4 mutation (44 available)
Tg(Nes-cre)1Kln mutation (4 available)
Trp53^tm1Tyj mutation (12 available); any Trp53 mutation (232 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:144617 )

• mice die by 32 weeks unlike Lig4^tm1Pmc/Lig4^tm1Pmc Tg(Nes-cre)1Kln mice with wild-type Trp53

neoplasm

increased medulloblastoma incidence ( J:144617 )

• 94% of mice develop medulloblastoma beginning at 16 weeks

nervous system

increased medulloblastoma incidence ( J:144617 )

• 94% of mice develop medulloblastoma beginning at 16 weeks

Allelic Composition	Lig4^tm1Pmc/Lig4^tm1Pmc Trp53^tm1Tyj/Trp53^tm1Tyj Xrcc2^tm2Pmc/Xrcc2^tm2Pmc Tg(Nes-cre)1Kln/0
Genetic Background	involves: 129S1/Sv * 129S2/SvPas * C57BL/6 * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:144617 )

• mice die by 16 weeks

neoplasm

increased medulloblastoma incidence ( J:144617 )

• 100% of mice develop medulloblastoma beginning at 14 weeks

nervous system

increased medulloblastoma incidence ( J:144617 )

• 100% of mice develop medulloblastoma beginning at 14 weeks

Allelic Composition	Lig4^tm1Pmc/Lig4^tm1Pmc Trp53^tm1Tyj/Trp53⁺ Xrcc2^tm2Pmc/Xrcc2^tm2Pmc Tg(Nes-cre)1Kln/0
Genetic Background	involves: 129S1/Sv * 129S2/SvPas * C57BL/6 * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:144617 )

• mice die by 32 weeks

neoplasm

abnormal tumor morphology ( J:144617 )

• tumors exhibit a loss of heterozygosity at the Trp53 gene

increased medulloblastoma incidence ( J:144617 )

• 75% of mice develop medulloblastoma beginning at 23 weeks

nervous system

increased medulloblastoma incidence ( J:144617 )

• 75% of mice develop medulloblastoma beginning at 23 weeks

Allelic Composition	Lig4^tm1Pmc/Lig4^tm1Pmc Meox2^tm1(cre)Sor/Meox2⁺
Genetic Background	involves: 129S1/Sv * 129S4/SvJaeSor

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lig4^tm1Pmc mutation (0 available); any Lig4 mutation (44 available)
Meox2^tm1(cre)Sor mutation (3 available); any Meox2 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal nervous system development ( J:144617 )

• mice exhibit neuraxis-wide apoptosis during development unlike in wild-type mice

Allelic Composition	Lig4^tm1Pmc/Lig4^tm1Pmc Tg(Nes-cre)1Kln/0
Genetic Background	involves: 129S1/Sv * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lig4^tm1Pmc mutation (0 available); any Lig4 mutation (44 available)
Tg(Nes-cre)1Kln mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal double-strand DNA break repair ( J:226703 )

• primary astrocytes show a defect in the repair of DNA double strand breaks after bleomycin treatment

nervous system

nervous system phenotype ( J:144617 )

N	• compared to germ line deletions of this gene, mice exhibit no increase in apoptosis during neural development

homeostasis/metabolism

abnormal double-strand DNA break repair ( J:226703 )

• primary astrocytes show a defect in the repair of DNA double strand breaks after bleomycin treatment

Allelic Composition	Lig4^tm1Pmc/Lig4^tm1Pmc Mre11a^tm1Jpt/Mre11a^tm1Jpt Tg(Nes-cre)1Kln/0
Genetic Background	involves: 129S1/SvImJ * 129S7/SvEvBrd * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lig4^tm1Pmc mutation (0 available); any Lig4 mutation (44 available)
Mre11a^tm1Jpt mutation (1 available); any Mre11a mutation (48 available)
Tg(Nes-cre)1Kln mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

ataxia ( J:144172 )

• at 7 to 9 months, mice develop severe hind-limb ataxia or unknown etiology

nervous system

nervous system phenotype ( J:144172 )

N	• unlike in mice with Lig4^tm1Pmc/Lig4^tm1Pmc Tg(Nes-cre)1Kln, mice do not exhibit any increased apoptosis in the nervous system, and microencephaly is rescued

Allelic Composition	Lig4^tm1Pmc/Lig4^tm1Pmc Nbn^tm1Jpt/Nbn^tm1Jpt Tg(Nes-cre)1Kln/0
Genetic Background	involves: 129S1/SvImJ * 129S7/SvEvBrd * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lig4^tm1Pmc mutation (0 available); any Lig4 mutation (44 available)
Nbn^tm1Jpt mutation (1 available); any Nbn mutation (59 available)
Tg(Nes-cre)1Kln mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal brain development ( J:144172 )

• at E13.5 and E15.5, neural tissue apoptosis is increased compared to in wild-type mice

decreased brain weight ( J:144172 )

growth/size/body

microcephaly ( J:144172 )

Allelic Composition	Lig4^tm1Pmc/Lig4^tm1Pmc Tg(Nes-cre)1Kln/0
Genetic Background	involves: 129S1/SvImJ * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lig4^tm1Pmc mutation (0 available); any Lig4 mutation (44 available)
Tg(Nes-cre)1Kln mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal brain development ( J:144172 )

• at E13.5 and E15.5, neural tissue apoptosis is increased compared to in wild-type mice

• however, brain morphology is otherwise normal

decreased brain size ( J:144172 )

• brain size is reduced as much as 40% compared to in littermate controls

decreased brain weight ( J:144172 )

homeostasis/metabolism

abnormal DNA repair ( J:144172 )

• DNA damage in the brain accumulates with age unlike in wild-type mice

• mice fail to repair ionizing radiation-induced DNA damage after 1 week compared to similarly treated wild-type mice that exhibit repair after 24 hours

behavior/neurological

ataxia ( J:144172 )

• at 7 to 9 months, mice develop severe hind-limb ataxia or unknown etiology

cellular

abnormal DNA repair ( J:144172 )

• DNA damage in the brain accumulates with age unlike in wild-type mice

• mice fail to repair ionizing radiation-induced DNA damage after 1 week compared to similarly treated wild-type mice that exhibit repair after 24 hours

growth/size/body

microcephaly ( J:144172 )

Allelic Composition	Atm^tm1Pmc/Atm^tm1Pmc Lig4^tm1Pmc/Lig4^tm1Pmc Tg(Nes-cre)1Kln/0
Genetic Background	involves: 129S1/SvImJ * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atm^tm1Pmc mutation (0 available); any Atm mutation (169 available)
Lig4^tm1Pmc mutation (0 available); any Lig4 mutation (44 available)
Tg(Nes-cre)1Kln mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

ataxia ( J:144172 )

• at 7 to 9 months, mice develop severe hind-limb ataxia or unknown etiology

nervous system

nervous system phenotype ( J:144172 )

N	• unlike in mice with Lig4^tm1Pmc/Lig4^tm1Pmc Tg(Nes-cre)1Kln, mice do not exhibit any increased apoptosis in the nervous system, and microcephaly is rescued

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