Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hesx1tm1(cre)Jpmb mutation
(0 available);
any
Hesx1 mutation
(14 available)
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mortality/aging
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• no homozygous offspring are identified
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nervous system
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• mice show reduced or absent telencephalon at 12.5 dpc (days post coitum)
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vision/eye
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• eye defects are fully penetrant with variable expressivity
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• some embryos display unilateral microphthalmia
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• some embryos display bilateral anophthalmia
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hesx1tm1(cre)Jpmb mutation
(0 available);
any
Hesx1 mutation
(14 available)
|
|
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vision/eye
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• partial penetrance and displayed a variable range of anterior defects
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• unilateral in some mice
• bilateral in some mice
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• unilateral in some mice
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nervous system
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hesx1tm1(cre)Jpmb mutation
(0 available);
any
Hesx1 mutation
(14 available)
|
|
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vision/eye
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• low incidence of unilateral microphthalmia
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hesx1tm1(cre)Jpmb mutation
(0 available);
any
Hesx1 mutation
(14 available)
Hesx1tm1Icar mutation
(0 available);
any
Hesx1 mutation
(14 available)
|
|
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vision/eye
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• partial penetrance and displayed a variable range of anterior defects
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• bilateral in some mice
• unilateral in some mice
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• unilateral in some mice
• bilateral in some mice
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nervous system
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm1Max mutation
(0 available);
any
Ctnnb1 mutation
(49 available)
Ctnnb1tm2Kem mutation
(1 available);
any
Ctnnb1 mutation
(49 available)
Hesx1tm1(cre)Jpmb mutation
(0 available);
any
Hesx1 mutation
(14 available)
Hesx1tm1Icar mutation
(0 available);
any
Hesx1 mutation
(14 available)
|
|
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vision/eye
|
• unilateral in some mice
• bilateral in some mice
|
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• unilateral in some mice
|
nervous system
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm2Kem mutation
(1 available);
any
Ctnnb1 mutation
(49 available)
Hesx1tm1(cre)Jpmb mutation
(0 available);
any
Hesx1 mutation
(14 available)
Hesx1tm1Icar mutation
(0 available);
any
Hesx1 mutation
(14 available)
|
|
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nervous system
vision/eye
|
• bilateral in some mice
• unilateral in some mice
|
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• unilateral in some mice
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation
(8 available);
any
Gt(ROSA)26Sor mutation
(942 available)
Hesx1tm1(cre)Jpmb mutation
(0 available);
any
Hesx1 mutation
(14 available)
Hesx1tm1Icar mutation
(0 available);
any
Hesx1 mutation
(14 available)
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nervous system
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• telencepepahlic vesicle development is often asymmetric in embryos, with the right side being more severely affected
• very small telencephalic vesicle is sometimes observed at the 8-10 somite stage
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vision/eye
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• development of optic vesicles is often asymmetric with right side more severely affected
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hesx1tm1(cre)Jpmb mutation
(0 available);
any
Hesx1 mutation
(14 available)
Tcf7l1tm1Efu mutation
(0 available);
any
Tcf7l1 mutation
(84 available)
Tcf7l1tm2Efu mutation
(0 available);
any
Tcf7l1 mutation
(84 available)
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vision/eye
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• unilateral in some mice
• bilateral in some mice
|
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• unilateral in some mice
• bilateral in some mice
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nervous system
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• severe truncation in some mice
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation
(8 available);
any
Gt(ROSA)26Sor mutation
(942 available)
Hesx1tm1(cre)Jpmb mutation
(0 available);
any
Hesx1 mutation
(14 available)
Hesx1tm2Jpmb mutation
(0 available);
any
Hesx1 mutation
(14 available)
|
|
|
nervous system
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• anterior to posterior cell fate transformation is detected at 10 days post coitum, resulting in anterior forebrain reduction
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation
(8 available);
any
Gt(ROSA)26Sor mutation
(942 available)
Hesx1tm1(cre)Jpmb mutation
(0 available);
any
Hesx1 mutation
(14 available)
Hesx1tm3Jpmb mutation
(0 available);
any
Hesx1 mutation
(14 available)
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nervous system
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• anterior to posterior cell fate transformation is detected at 10 days post coitum, resulting in anterior forebrain reduction
• alterations are more severe than observed in corresponding Hesx1tm2Jpmb compound mutants
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation
(8 available);
any
Gt(ROSA)26Sor mutation
(942 available)
Hesx1tm1(cre)Jpmb mutation
(0 available);
any
Hesx1 mutation
(14 available)
|
|
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(Hesx1)Jpmb mutation
(0 available);
any
Gt(ROSA)26Sor mutation
(942 available)
Hesx1tm1(cre)Jpmb mutation
(0 available);
any
Hesx1 mutation
(14 available)
|
|
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mortality/aging
N |
• number of mice identified at weaning is similar to the expected numbers
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vision/eye
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• all mutants surviving to weaninig age display eye defects
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• bilateral microphthalmia was seen in some embryos
|
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• some embryos show bilateral anophthalmia, whereas others have unilateral anophthalmia
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(Hesx1)Jpmb mutation
(0 available);
any
Gt(ROSA)26Sor mutation
(942 available)
Hesx1tm1(cre)Jpmb mutation
(0 available);
any
Hesx1 mutation
(14 available)
|
|
|
mortality/aging
|
• mice surviving to weaning age are reduced in number when compared to expected numbers
|
vision/eye
|
• all mutants surviving to weaninig age display eye defects
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hesx1tm1(cre)Jpmb mutation
(0 available);
any
Hesx1 mutation
(14 available)
Hesx1tm1Icar mutation
(0 available);
any
Hesx1 mutation
(14 available)
Tcf7l1tm2Efu mutation
(0 available);
any
Tcf7l1 mutation
(84 available)
|
|
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nervous system
|
• almost complete loss of most of the anterior forebrain
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm1Max mutation
(0 available);
any
Ctnnb1 mutation
(49 available)
Hesx1tm1(cre)Jpmb mutation
(0 available);
any
Hesx1 mutation
(14 available)
Hesx1tm1Icar mutation
(0 available);
any
Hesx1 mutation
(14 available)
|
|
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nervous system
vision/eye
|
• bilateral in some mice
• unilateral in some mice
|
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• unilateral in some mice
|