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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Hesx1tm1(cre)Jpmb
targeted mutation 1, Juan Pedro Martinez Barbera
MGI:3822473
Summary 15 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Hesx1tm1(cre)Jpmb/Hesx1tm1(cre)Jpmb B6.129S-Hesx1tm1(cre)Jpmb MGI:3822764
hm2
Hesx1tm1(cre)Jpmb/Hesx1tm1(cre)Jpmb involves: 129S/SvEv MGI:5314530
ht3
Hesx1tm1(cre)Jpmb/Hesx1+ involves: 129S/SvEv MGI:5314529
ht4
Hesx1tm1(cre)Jpmb/Hesx1tm1Icar involves: 129P2/OlaHsd * 129S/SvEv MGI:5314531
cn5
Ctnnb1tm1Max/Ctnnb1tm2Kem
Hesx1tm1(cre)Jpmb/Hesx1tm1Icar
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ MGI:5314536
cn6
Ctnnb1tm2Kem/Ctnnb1+
Hesx1tm1(cre)Jpmb/Hesx1tm1Icar
involves: 129P2/OlaHsd * 129S/SvEv * 129S1/Sv * 129X1/SvJ MGI:5314537
cn7
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Hesx1tm1(cre)Jpmb/Hesx1tm1Icar
involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 MGI:3822771
cn8
Hesx1tm1(cre)Jpmb/Hesx1+
Tcf7l1tm1Efu/Tcf7l1tm2Efu
involves: 129S/SvEv MGI:5314534
cn9
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Hesx1tm1(cre)Jpmb/Hesx1tm2Jpmb
involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * FVB/N MGI:3822877
cn10
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Hesx1tm1(cre)Jpmb/Hesx1tm3Jpmb
involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * FVB/N MGI:3822876
cn11
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Hesx1tm1(cre)Jpmb/Hesx1+
involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * FVB/N MGI:3822878
cn12
Gt(ROSA)26Sortm1(Hesx1)Jpmb/Gt(ROSA)26Sortm1(Hesx1)Jpmb
Hesx1tm1(cre)Jpmb/Hesx1tm1(cre)Jpmb
involves: 129S/SvEv * C57BL/6 * SJL MGI:3822770
cn13
Gt(ROSA)26Sortm1(Hesx1)Jpmb/Gt(ROSA)26Sor+
Hesx1tm1(cre)Jpmb/Hesx1tm1(cre)Jpmb
involves: 129S/SvEv * C57BL/6 * SJL MGI:3822769
cx14
Hesx1tm1(cre)Jpmb/Hesx1tm1Icar
Tcf7l1tm2Efu/Tcf7l1+
involves: 129P2/OlaHsd * 129S/SvEv MGI:5314533
cx15
Ctnnb1tm1Max/Ctnnb1+
Hesx1tm1(cre)Jpmb/Hesx1tm1Icar
involves: 129P2/OlaHsd * 129S/SvEv * 129S1/Sv * 129X1/SvJ MGI:5314535


Genotype
MGI:3822764
hm1
Allelic
Composition
Hesx1tm1(cre)Jpmb/Hesx1tm1(cre)Jpmb
Genetic
Background
B6.129S-Hesx1tm1(cre)Jpmb
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hesx1tm1(cre)Jpmb mutation (0 available); any Hesx1 mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• no homozygous offspring are identified

nervous system
• mice show reduced or absent telencephalon at 12.5 dpc (days post coitum)

vision/eye
• eye defects are fully penetrant with variable expressivity
• some embryos display unilateral microphthalmia
• some embryos display bilateral anophthalmia




Genotype
MGI:5314530
hm2
Allelic
Composition
Hesx1tm1(cre)Jpmb/Hesx1tm1(cre)Jpmb
Genetic
Background
involves: 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hesx1tm1(cre)Jpmb mutation (0 available); any Hesx1 mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• partial penetrance and displayed a variable range of anterior defects
• unilateral in some mice
• bilateral in some mice
• unilateral in some mice

nervous system




Genotype
MGI:5314529
ht3
Allelic
Composition
Hesx1tm1(cre)Jpmb/Hesx1+
Genetic
Background
involves: 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hesx1tm1(cre)Jpmb mutation (0 available); any Hesx1 mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• low incidence of unilateral microphthalmia




Genotype
MGI:5314531
ht4
Allelic
Composition
Hesx1tm1(cre)Jpmb/Hesx1tm1Icar
Genetic
Background
involves: 129P2/OlaHsd * 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hesx1tm1(cre)Jpmb mutation (0 available); any Hesx1 mutation (11 available)
Hesx1tm1Icar mutation (0 available); any Hesx1 mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• partial penetrance and displayed a variable range of anterior defects
• bilateral in some mice
• unilateral in some mice
• unilateral in some mice
• bilateral in some mice

nervous system




Genotype
MGI:5314536
cn5
Allelic
Composition
Ctnnb1tm1Max/Ctnnb1tm2Kem
Hesx1tm1(cre)Jpmb/Hesx1tm1Icar
Genetic
Background
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm1Max mutation (0 available); any Ctnnb1 mutation (41 available)
Ctnnb1tm2Kem mutation (1 available); any Ctnnb1 mutation (41 available)
Hesx1tm1(cre)Jpmb mutation (0 available); any Hesx1 mutation (11 available)
Hesx1tm1Icar mutation (0 available); any Hesx1 mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• unilateral in some mice
• bilateral in some mice
• unilateral in some mice

nervous system




Genotype
MGI:5314537
cn6
Allelic
Composition
Ctnnb1tm2Kem/Ctnnb1+
Hesx1tm1(cre)Jpmb/Hesx1tm1Icar
Genetic
Background
involves: 129P2/OlaHsd * 129S/SvEv * 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm2Kem mutation (1 available); any Ctnnb1 mutation (41 available)
Hesx1tm1(cre)Jpmb mutation (0 available); any Hesx1 mutation (11 available)
Hesx1tm1Icar mutation (0 available); any Hesx1 mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system

vision/eye
• bilateral in some mice
• unilateral in some mice
• unilateral in some mice




Genotype
MGI:3822771
cn7
Allelic
Composition
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Hesx1tm1(cre)Jpmb/Hesx1tm1Icar
Genetic
Background
involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (8 available); any Gt(ROSA)26Sor mutation (745 available)
Hesx1tm1(cre)Jpmb mutation (0 available); any Hesx1 mutation (11 available)
Hesx1tm1Icar mutation (0 available); any Hesx1 mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• telencepepahlic vesicle development is often asymmetric in embryos, with the right side being more severely affected
• very small telencephalic vesicle is sometimes observed at the 8-10 somite stage

vision/eye
• development of optic vesicles is often asymmetric with right side more severely affected




Genotype
MGI:5314534
cn8
Allelic
Composition
Hesx1tm1(cre)Jpmb/Hesx1+
Tcf7l1tm1Efu/Tcf7l1tm2Efu
Genetic
Background
involves: 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hesx1tm1(cre)Jpmb mutation (0 available); any Hesx1 mutation (11 available)
Tcf7l1tm1Efu mutation (0 available); any Tcf7l1 mutation (78 available)
Tcf7l1tm2Efu mutation (0 available); any Tcf7l1 mutation (78 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• unilateral in some mice
• bilateral in some mice
• unilateral in some mice
• bilateral in some mice

nervous system
• severe truncation in some mice




Genotype
MGI:3822877
cn9
Allelic
Composition
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Hesx1tm1(cre)Jpmb/Hesx1tm2Jpmb
Genetic
Background
involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (8 available); any Gt(ROSA)26Sor mutation (745 available)
Hesx1tm1(cre)Jpmb mutation (0 available); any Hesx1 mutation (11 available)
Hesx1tm2Jpmb mutation (0 available); any Hesx1 mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• anterior to posterior cell fate transformation is detected at 10 days post coitum, resulting in anterior forebrain reduction




Genotype
MGI:3822876
cn10
Allelic
Composition
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Hesx1tm1(cre)Jpmb/Hesx1tm3Jpmb
Genetic
Background
involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (8 available); any Gt(ROSA)26Sor mutation (745 available)
Hesx1tm1(cre)Jpmb mutation (0 available); any Hesx1 mutation (11 available)
Hesx1tm3Jpmb mutation (0 available); any Hesx1 mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• anterior to posterior cell fate transformation is detected at 10 days post coitum, resulting in anterior forebrain reduction
• alterations are more severe than observed in corresponding Hesx1tm2Jpmb compound mutants




Genotype
MGI:3822878
cn11
Allelic
Composition
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Hesx1tm1(cre)Jpmb/Hesx1+
Genetic
Background
involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (8 available); any Gt(ROSA)26Sor mutation (745 available)
Hesx1tm1(cre)Jpmb mutation (0 available); any Hesx1 mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype




Genotype
MGI:3822770
cn12
Allelic
Composition
Gt(ROSA)26Sortm1(Hesx1)Jpmb/Gt(ROSA)26Sortm1(Hesx1)Jpmb
Hesx1tm1(cre)Jpmb/Hesx1tm1(cre)Jpmb
Genetic
Background
involves: 129S/SvEv * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(Hesx1)Jpmb mutation (0 available); any Gt(ROSA)26Sor mutation (745 available)
Hesx1tm1(cre)Jpmb mutation (0 available); any Hesx1 mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• number of mice identified at weaning is similar to the expected numbers

vision/eye
• all mutants surviving to weaninig age display eye defects
• bilateral microphthalmia was seen in some embryos
• some embryos show bilateral anophthalmia, whereas others have unilateral anophthalmia




Genotype
MGI:3822769
cn13
Allelic
Composition
Gt(ROSA)26Sortm1(Hesx1)Jpmb/Gt(ROSA)26Sor+
Hesx1tm1(cre)Jpmb/Hesx1tm1(cre)Jpmb
Genetic
Background
involves: 129S/SvEv * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(Hesx1)Jpmb mutation (0 available); any Gt(ROSA)26Sor mutation (745 available)
Hesx1tm1(cre)Jpmb mutation (0 available); any Hesx1 mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice surviving to weaning age are reduced in number when compared to expected numbers

vision/eye
• all mutants surviving to weaninig age display eye defects




Genotype
MGI:5314533
cx14
Allelic
Composition
Hesx1tm1(cre)Jpmb/Hesx1tm1Icar
Tcf7l1tm2Efu/Tcf7l1+
Genetic
Background
involves: 129P2/OlaHsd * 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hesx1tm1(cre)Jpmb mutation (0 available); any Hesx1 mutation (11 available)
Hesx1tm1Icar mutation (0 available); any Hesx1 mutation (11 available)
Tcf7l1tm2Efu mutation (0 available); any Tcf7l1 mutation (78 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• almost complete loss of most of the anterior forebrain




Genotype
MGI:5314535
cx15
Allelic
Composition
Ctnnb1tm1Max/Ctnnb1+
Hesx1tm1(cre)Jpmb/Hesx1tm1Icar
Genetic
Background
involves: 129P2/OlaHsd * 129S/SvEv * 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm1Max mutation (0 available); any Ctnnb1 mutation (41 available)
Hesx1tm1(cre)Jpmb mutation (0 available); any Hesx1 mutation (11 available)
Hesx1tm1Icar mutation (0 available); any Hesx1 mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system

vision/eye
• bilateral in some mice
• unilateral in some mice
• unilateral in some mice





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last database update
01/12/2022
MGI 6.17
The Jackson Laboratory