Tcf7l1tm2Efu
Targeted Allele Detail
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Symbol: |
Tcf7l1tm2Efu |
Name: |
transcription factor 7 like 1 (T cell specific, HMG box); targeted mutation 2, Elaine Fuchs |
MGI ID: |
MGI:3044616 |
Synonyms: |
Tcf3- |
Gene: |
Tcf7l1 Location: Chr6:72603354-72766028 bp, - strand Genetic Position: Chr6, 32.27 cM
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Alliance: |
Tcf7l1tm2Efu page
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Germline Transmission: |
Earliest citation of germline transmission:
J:90402
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Parent Cell Line: |
GS1 (ES Cell)
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Strain of Origin: |
129/Sv
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A loxP flanked 64 bp segment of exon 2 and a neo cassette were inserted via homologous recombination then removed via cre mediated recombination prior to generation of chimeric mice. The resulting allele lacked exon 2 and contained a frameshift and early termination codon. Immunoblot analysis confirmed the absence of protein expression in homozygous embryos
(J:90402)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Tcf7l1 Mutation: |
84 strains or lines available
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Original: |
J:90402 Merrill BJ, et al., Tcf3: a transcriptional regulator of axis induction in the early embryo. Development. 2004 Jan;131(2):263-74 |
All: |
4 reference(s) |
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