About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Nr2e1tm1Rev
targeted mutation 1, Ronald M Evans
MGI:3777019
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
Nr2e1tm1Rev/Nr2e1tm1Rtyu Not Specified MGI:3777340
cn2
Nr2e1tm1Rev/Nr2e1tm1Rev
Tg(CAG-cre/Esr1*)5Amc/?
involves: C57BL/6 * CBA MGI:3777343
cn3
Nr2e1tm1Rev/Nr2e1tm1Rev
Tg(Nes-cre)1Kln/0
involves: C57BL/6 * SJL MGI:3777346


Genotype
MGI:3777340
ht1
Allelic
Composition
Nr2e1tm1Rev/Nr2e1tm1Rtyu
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr2e1tm1Rev mutation (0 available); any Nr2e1 mutation (3 available)
Nr2e1tm1Rtyu mutation (0 available); any Nr2e1 mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• isolated neural stem cells infected with a cre-expressing virus display an 80% reduction in proliferation

cellular
• isolated neural stem cells infected with a cre-expressing virus display an 80% reduction in proliferation




Genotype
MGI:3777343
cn2
Allelic
Composition
Nr2e1tm1Rev/Nr2e1tm1Rev
Tg(CAG-cre/Esr1*)5Amc/?
Genetic
Background
involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr2e1tm1Rev mutation (0 available); any Nr2e1 mutation (3 available)
Tg(CAG-cre/Esr1*)5Amc mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• three weeks of voluntary running results in an increased number of dividing cells in the brain
• reduced pool of neural stem cells

behavior/neurological
N
• contextual fear conditioning is normal
• tone-cued memory is normal

cellular
• three weeks of voluntary running results in an increased number of dividing cells in the brain
• reduced pool of neural stem cells




Genotype
MGI:3777346
cn3
Allelic
Composition
Nr2e1tm1Rev/Nr2e1tm1Rev
Tg(Nes-cre)1Kln/0
Genetic
Background
involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr2e1tm1Rev mutation (0 available); any Nr2e1 mutation (3 available)
Tg(Nes-cre)1Kln mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system

vision/eye
N
• visual function remains at 2-4 months

behavior/neurological
N
• contextual fear conditioning is normal
• profoundly impaired in a Morris water maze test
• deficient short term memory but normal long term memory in a Morris water maze





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
10/08/2019
MGI 6.14
The Jackson Laboratory