Nr2e1^tm1Rtyu
Targeted Allele Detail

Summary

• Symbol: Nr2e1^tm1Rtyu
• Name: nuclear receptor subfamily 2, group E, member 1; targeted mutation 1, Ruth T Yu
• MGI ID: MGI:2176560
• Synonyms: Tlx-, Tlx^LacZ, Tlx^Z
• Gene: Nr2e1 Location: Chr10:42437959-42459628 bp, - strand Genetic Position: Chr10, 22.89 cM
• Alliance: Nr2e1^tm1Rtyu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:61179
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• A lacZ neomycin cassette replaces exons 3, 4 and 5. (J:61179)

Expression

In Mice Carrying this Mutation:	30 assay results
In Structures Affected by this Mutation:	11 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nr2e1 Mutation: 32 strains or lines available

References

• Original: J:61179 Yu RT, et al., The orphan nuclear receptor Tlx regulates Pax2 and is essential for vision. Proc Natl Acad Sci U S A. 2000 Mar 14;97(6):2621-5
• All: 16 reference(s)