Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc34a3tm1.1Nhch mutation
(1 available);
any
Slc34a3 mutation
(24 available)
Tg(Pax8-rtTA2S*M2)1Koes mutation
(3 available)
Tg(tetO-cre)LC1Bjd mutation
(2 available)
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Pax8-rtTA2S*M2)1Koes mutation
(3 available)
Tg(tetO-cre)1Jaw mutation
(5 available)
Tulp3tm1c(EUCOMM)Hmgu mutation
(2 available);
any
Tulp3 mutation
(53 available)
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renal/urinary system
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• mice treated with Dox at P28 for 2 weeks and analyzed at 41-42 weeks of age show slow development of kidney cysts
• mice treated with Dox at P0 and analyzed at P14 show a modest kidney phenotype, with a few cysts
• however, blood urea nitrogen levels are normal in Dox treated mice
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• mice treated with doxycycline (Dox) at P0 and analyzed at P14 show a modest kidney phenotype, with mild tubule dilatations
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growth/size/body
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• mice treated with Dox at P28 for 2 weeks and analyzed at 41-42 weeks of age show slow development of kidney cysts
• mice treated with Dox at P0 and analyzed at P14 show a modest kidney phenotype, with a few cysts
• however, blood urea nitrogen levels are normal in Dox treated mice
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mortality/aging
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• following exposure to doxycycline in utero, mice die 3 to 4 weeks after birth with giant polycystic kidneys
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renal/urinary system
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• following exposure to doxycycline in utero, newborn mice exhibit fulminant cysts and giant polycystic kidneys form by 3 to 4 weeks of age
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• following exposure to doxycycline in utero, new born mice exhibit hyperplasia of the proximal and distal tubules and collecting duct epithelium
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growth/size/body
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• following exposure to doxycycline in utero, newborn mice exhibit fulminant cysts and giant polycystic kidneys form by 3 to 4 weeks of age
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renal/urinary system
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• mice treated with doxycycline (Dox) at P0 and analyzed at P14 do not form kidney cysts
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renal/urinary system
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• mice treated with doxycycline (Dox) at P0 and analyzed at P14 show development of kidney cysts, with increased kidney weight/body weight ratio and more numerous and larger cysts than single conditional Tulp3 homozygotes
• however, mice treated with Dox at P28 and analyzed at 18 weeks of age show amelioration of the cystic phenotype with no difference in cystic index
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• mice treated with doxycycline (Dox) at P0 and analyzed at P14 show increased kidney weight/body weight ratio due to cysts
• mice treated with Dox at P28 for 2 weeks and analyzed at 18 weeks of age show a modest elevation of kidney weight/body weight ratio
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• mice treated with Dox at P28 for 2 weeks and analyzed at 18 weeks of age show larger tubule dilations
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homeostasis/metabolism
growth/size/body
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• mice treated with doxycycline (Dox) at P0 and analyzed at P14 show development of kidney cysts, with increased kidney weight/body weight ratio and more numerous and larger cysts than single conditional Tulp3 homozygotes
• however, mice treated with Dox at P28 and analyzed at 18 weeks of age show amelioration of the cystic phenotype with no difference in cystic index
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• mice treated with doxycycline (Dox) at P0 and analyzed at P14 show increased kidney weight/body weight ratio due to cysts
• mice treated with Dox at P28 for 2 weeks and analyzed at 18 weeks of age show a modest elevation of kidney weight/body weight ratio
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renal/urinary system
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• mice treated with Dox at P0 and analyzed at P14 exhibit a severe cystic phenotype
• mice treated with Dox at P28 for 2 weeks and analyzed at 18 weeks develop severe cystic kidneys
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• mice treated with doxycycline (Dox) at P0 and analyzed at P14 exhibit increased kidney weight/body weight ratio due to cysts
• mice treated with Dox at P28 for 2 weeks and analyzed at 18 weeks exhibit increased kidney weight/body weight ratio due to cysts
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homeostasis/metabolism
growth/size/body
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• mice treated with Dox at P0 and analyzed at P14 exhibit a severe cystic phenotype
• mice treated with Dox at P28 for 2 weeks and analyzed at 18 weeks develop severe cystic kidneys
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• mice treated with doxycycline (Dox) at P0 and analyzed at P14 exhibit increased kidney weight/body weight ratio due to cysts
• mice treated with Dox at P28 for 2 weeks and analyzed at 18 weeks exhibit increased kidney weight/body weight ratio due to cysts
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renal/urinary system
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• mice treated with doxycycline (Dox) at P0 and analyzed at P14 exhibit a severe cystic phenotype
• mice treated with Dox a P28 for 2 weeks and analyzed at 18 weeks show an intermediate cystic phenotype, with cystic index lower than conditional Pkd1 homozygotes but higher than in double Tulp3 and Pkd1 homozygotes
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• mice treated with doxycycline (Dox) at P0 and analyzed at P14 exhibit increased kidney weight/body weight ratio due to cysts
• mice treated with Dox a P28 for 2 weeks and analyzed at 18 weeks show an intermediate kidney weight/body weight ratio, with lower ratio than conditional Pkd1 homozygotes but higher ratio than in double Tulp3 and Pkd1 homozygotes
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homeostasis/metabolism
growth/size/body
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• mice treated with doxycycline (Dox) at P0 and analyzed at P14 exhibit a severe cystic phenotype
• mice treated with Dox a P28 for 2 weeks and analyzed at 18 weeks show an intermediate cystic phenotype, with cystic index lower than conditional Pkd1 homozygotes but higher than in double Tulp3 and Pkd1 homozygotes
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• mice treated with doxycycline (Dox) at P0 and analyzed at P14 exhibit increased kidney weight/body weight ratio due to cysts
• mice treated with Dox a P28 for 2 weeks and analyzed at 18 weeks show an intermediate kidney weight/body weight ratio, with lower ratio than conditional Pkd1 homozygotes but higher ratio than in double Tulp3 and Pkd1 homozygotes
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renal/urinary system
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• mice treated with doxycycline (Dox) at P0 and analyzed at P14 exhibit a severe cystic phenotype
• however, mice treated with Dox at P28 and analyzed at 18 weeks of age show amelioration of the cystic phenotype with no difference in cystic index
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• mice treated with doxycycline (Dox) at P0 and analyzed at P14 exhibit increased kidney weight/body weight ratio due to cysts
• however, mice treated with Dox at P28 for 2 weeks and analyzed at 18 weeks of age show no differences in kidney weight/body weight ratio
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homeostasis/metabolism
growth/size/body
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• mice treated with doxycycline (Dox) at P0 and analyzed at P14 exhibit a severe cystic phenotype
• however, mice treated with Dox at P28 and analyzed at 18 weeks of age show amelioration of the cystic phenotype with no difference in cystic index
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• mice treated with doxycycline (Dox) at P0 and analyzed at P14 exhibit increased kidney weight/body weight ratio due to cysts
• however, mice treated with Dox at P28 for 2 weeks and analyzed at 18 weeks of age show no differences in kidney weight/body weight ratio
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdc42tm1Brak mutation
(0 available);
any
Cdc42 mutation
(43 available)
Tg(Pax8-rtTA2S*M2)1Koes mutation
(3 available)
Tg(tetO-cre)LC1Bjd mutation
(2 available)
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homeostasis/metabolism
renal/urinary system
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• following ischemia/reperfusion injury, doxycycline-treated mice exhibit a misorganized, multi-layered, hyperproliferative epithelium and impaired recovery of renal function
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• following ischemia/reperfusion injury, doxycycline-treated mice exhibit a misorganized, multi-layered, hyperproliferative epithelium and impaired recovery of renal function
• dividing cells of doxycycline-treated mice during kidney repair show a high shift toward mitotic spindle angles perpendicular to the epithelial plane
• however, doxycline-treated mice exhibit normal kidney histology and function under basal conditions
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Pax8-rtTA2S*M2)1Koes mutation
(3 available)
Tg(tetO-TGFB1*C223S*C225S)1Glk mutation
(0 available)
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renal/urinary system
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• doxycycline-treated mice (six cycles of discontinuous treatment) show distinct renal fibrosis
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Pax8-rtTA2S*M2)1Koes mutation
(3 available)
Tg(tetO-GFP,-APOL1*S342G*I384M)#Susz mutation
(0 available)
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Pax8-rtTA2S*M2)1Koes mutation
(3 available)
Tg(tetO-GFP,-APOL1*)#Susz mutation
(0 available)
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Pax8-rtTA2S*M2)1Koes mutation
(3 available)
Tg(tetO-MYC)36aBop mutation
(1 available)
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renal/urinary system
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• following induction with doxycycline, mice develop glomerular cysts
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• following induction with doxycycline, mice develop multiple renal cysts in all renal tubular compartments
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• following induction with doxycycline
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• 3 to 4 months following induction with doxycycline
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neoplasm
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• following induction with doxycycline, mice develop renal adenomas
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• following induction with doxycycline
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growth/size/body
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• following induction with doxycycline, mice develop glomerular cysts
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• following induction with doxycycline, mice develop multiple renal cysts in all renal tubular compartments
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Analysis Tools