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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Jag1tm2Grid
targeted mutation 2, Tom Gridley
MGI:3692444
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Jag1tm1Grid/Jag1tm2Grid
Foxg1tm1(cre)Skm/Foxg1+
involves: 129P2/OlaHsd * 129S1/Sv MGI:3693201
cn2
Jag1tm2Grid/Jag1tm2Grid
Tg(Wnt1-cre)11Rth/0
involves: 129S1/Sv * C57BL/6 * CBA MGI:5318528
cn3
Jag1tm1Grid/Jag1tm2Grid
Tg(Tagln-cre)1Her/0
involves: 129S1/Sv * C57BL/6 * SJL MGI:4867007
cn4
Jag1tm2Grid/Jag1tm2Grid
Tg(Tek-cre)12Flv/0
involves: C3H * C57BL/6 MGI:4867008


Genotype
MGI:3693201
cn1
Allelic
Composition
Jag1tm1Grid/Jag1tm2Grid
Foxg1tm1(cre)Skm/Foxg1+
Genetic
Background
involves: 129P2/OlaHsd * 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxg1tm1(cre)Skm mutation (2 available); any Foxg1 mutation (3 available)
Jag1tm1Grid mutation (1 available); any Jag1 mutation (8 available)
Jag1tm2Grid mutation (1 available); any Jag1 mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mutants survive through E18.5 (J:115783)
• mutants survive through E18.5 (J:115783)

hearing/vestibular/ear
N
• at E15.5, inner ear structures not associated with sensory formation such as endolymphatic duct and sac, and crus are not affected (J:115783)
• at E15.5, inner ear structures not associated with sensory formation such as endolymphatic duct and sac, and crus are not affected (J:115783)
• formation of prosensory domain is disrupted by E18.5 (J:115783)
• formation of prosensory domain is disrupted by E18.5 (J:115783)
• severe hair cell patterning defects are observed at E18.5 (J:115783)
• no clear formation of rows or distinction between inner and outer hair cells is observed in midbasal regions of the organ of Corti; hair cells form in patches (J:115783)
• at E16.5, patterns look similar to those at E18.5 with patches of hair cells in midbasal regions and absent hair cells in very basal regions (J:115783)
• in middle portion of cochlea, patterning of inner and sparse outer hair cells is abnormal (J:115783)
• severe hair cell patterning defects are observed at E18.5 (J:115783)
• no clear formation of rows or distinction between inner and outer hair cells is observed in midbasal regions of the organ of Corti; hair cells form in patches (J:115783)
• at E16.5, patterns look similar to those at E18.5 with patches of hair cells in midbasal regions and absent hair cells in very basal regions (J:115783)
• in middle portion of cochlea, patterning of inner and sparse outer hair cells is abnormal (J:115783)
• in apical turn of cochlea, there are only two rows instead of four rows of hair cells (J:115783)
• in apical turn of cochlea, there are only two rows instead of four rows of hair cells (J:115783)
• no hair cell formation is observed in basal turns of cochlea; at E18.5, hair cells and supporting cells are absent in very basal region of cochlea (J:115783)
• no hair cell formation is observed in basal turns of cochlea; at E18.5, hair cells and supporting cells are absent in very basal region of cochlea (J:115783)
• no outer hair cells or supporting Deiter's cells are present in apex of cochlea (J:115783)
• no outer hair cells or supporting Deiter's cells are present in apex of cochlea (J:115783)
• at E18.5, tunnel of Corti is not apparent (J:115783)
• at E18.5, tunnel of Corti is not apparent (J:115783)
• semicircular canals are mostly absent, with only a small portion of lateral semicircular canal present at E15.5 (J:115783)
• semicircular canals are mostly absent, with only a small portion of lateral semicircular canal present at E15.5 (J:115783)
• cristae and ampullae are missing or severely disrupted by E14.5 in homozygotes (J:115783)
• cristae and ampullae are missing or severely disrupted by E14.5 in homozygotes (J:115783)
• at E15.5, only a small portion of the anterior canal is present in homozygotes (J:115783)
• at E15.5, only a small portion of the anterior canal is present in homozygotes (J:115783)
• at E15.5, semicircular canals are largely absent (J:115783)
• at E15.5, semicircular canals are largely absent (J:115783)
• structure is extremely small, with few differentiating hair cells; severe disruption of differentiation of utricular macula is observed (J:115783)
• structure is extremely small, with few differentiating hair cells; severe disruption of differentiation of utricular macula is observed (J:115783)
• observed at E13.5 (J:115783)
• observed at E13.5 (J:115783)
• at E13.5, saccule appears misshapen (J:115783)
• at E18.5, saccule and macula are relatively normal, but entire saccular structure is shaped differently compared to controls (J:115783)
• at E13.5, saccule appears misshapen (J:115783)
• at E18.5, saccule and macula are relatively normal, but entire saccular structure is shaped differently compared to controls (J:115783)

nervous system
• severe hair cell patterning defects are observed at E18.5 (J:115783)
• no clear formation of rows or distinction between inner and outer hair cells is observed in midbasal regions of the organ of Corti; hair cells form in patches (J:115783)
• at E16.5, patterns look similar to those at E18.5 with patches of hair cells in midbasal regions and absent hair cells in very basal regions (J:115783)
• in middle portion of cochlea, patterning of inner and sparse outer hair cells is abnormal (J:115783)
• severe hair cell patterning defects are observed at E18.5 (J:115783)
• no clear formation of rows or distinction between inner and outer hair cells is observed in midbasal regions of the organ of Corti; hair cells form in patches (J:115783)
• at E16.5, patterns look similar to those at E18.5 with patches of hair cells in midbasal regions and absent hair cells in very basal regions (J:115783)
• in middle portion of cochlea, patterning of inner and sparse outer hair cells is abnormal (J:115783)
• in apical turn of cochlea, there are only two rows instead of four rows of hair cells (J:115783)
• in apical turn of cochlea, there are only two rows instead of four rows of hair cells (J:115783)
• no hair cell formation is observed in basal turns of cochlea; at E18.5, hair cells and supporting cells are absent in very basal region of cochlea (J:115783)
• no hair cell formation is observed in basal turns of cochlea; at E18.5, hair cells and supporting cells are absent in very basal region of cochlea (J:115783)
• no outer hair cells or supporting Deiter's cells are present in apex of cochlea (J:115783)
• no outer hair cells or supporting Deiter's cells are present in apex of cochlea (J:115783)




Genotype
MGI:5318528
cn2
Allelic
Composition
Jag1tm2Grid/Jag1tm2Grid
Tg(Wnt1-cre)11Rth/0
Genetic
Background
involves: 129S1/Sv * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jag1tm2Grid mutation (1 available); any Jag1 mutation (8 available)
Tg(Wnt1-cre)11Rth mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• maxilla deficiencies lead to poor feeding and death around one month of age (J:181120)
• maxilla deficiencies lead to poor feeding and death around one month of age (J:181120)

growth/size/body
• the palatal dimensions are proportionally smaller, however the structural components are in tact (J:181120)
• mutants exhibit reduced proliferation in the palate shelves at E14.5 and in the adjacent palatal epithelium (J:181120)
• mutants exhibit reduced hyaluronic acid in the palate shelves at E14.5 (J:181120)
• mutants exhibit aberrant vascular pattering in the palate including reduced vascular branching at E14.5 and E15.5 (J:181120)
• the palatal dimensions are proportionally smaller, however the structural components are in tact (J:181120)
• mutants exhibit reduced proliferation in the palate shelves at E14.5 and in the adjacent palatal epithelium (J:181120)
• mutants exhibit reduced hyaluronic acid in the palate shelves at E14.5 (J:181120)
• mutants exhibit aberrant vascular pattering in the palate including reduced vascular branching at E14.5 and E15.5 (J:181120)
• at E14.5, palatal shelf elevation above the tongue occurs normally but palatal elongation is reduced anteriorly, whereas the posterior palate shelf length is unaffected (J:181120)
• mutants exhibit delayed palatal shelf elongation (J:181120)
• some E15.5 mutants show delayed palate shelf apposition and the persistence of the epithelial seam, however palate fusion occurs in all mutants (J:181120)
• at E14.5, palatal shelf elevation above the tongue occurs normally but palatal elongation is reduced anteriorly, whereas the posterior palate shelf length is unaffected (J:181120)
• mutants exhibit delayed palatal shelf elongation (J:181120)
• some E15.5 mutants show delayed palate shelf apposition and the persistence of the epithelial seam, however palate fusion occurs in all mutants (J:181120)
• palate shelf height is reduced in both the anterior and posterior regions (J:181120)
• palate shelf height is reduced in both the anterior and posterior regions (J:181120)
• midfacial hypoplasia resulting in a reduction in anterior facial width (J:181120)
• midfacial hypoplasia resulting in a reduction in anterior facial width (J:181120)

craniofacial
• shortened maxillary regions; anterior-posterior facial length is normal at P0 but over time the mutants exhibit smaller maxillary lengths (J:181120)
• the inframaxillary length and the posterior-anterior length are reduced (J:181120)
• shortened maxillary regions; anterior-posterior facial length is normal at P0 but over time the mutants exhibit smaller maxillary lengths (J:181120)
• the inframaxillary length and the posterior-anterior length are reduced (J:181120)
• dental occlusion is misaligned with severe midface hypoplasia requiring trimming of the lower incisors weekly (J:181120)
• dental occlusion is misaligned with severe midface hypoplasia requiring trimming of the lower incisors weekly (J:181120)
• the palatal dimensions are proportionally smaller, however the structural components are in tact (J:181120)
• mutants exhibit reduced proliferation in the palate shelves at E14.5 and in the adjacent palatal epithelium (J:181120)
• mutants exhibit reduced hyaluronic acid in the palate shelves at E14.5 (J:181120)
• mutants exhibit aberrant vascular pattering in the palate including reduced vascular branching at E14.5 and E15.5 (J:181120)
• the palatal dimensions are proportionally smaller, however the structural components are in tact (J:181120)
• mutants exhibit reduced proliferation in the palate shelves at E14.5 and in the adjacent palatal epithelium (J:181120)
• mutants exhibit reduced hyaluronic acid in the palate shelves at E14.5 (J:181120)
• mutants exhibit aberrant vascular pattering in the palate including reduced vascular branching at E14.5 and E15.5 (J:181120)
• at E14.5, palatal shelf elevation above the tongue occurs normally but palatal elongation is reduced anteriorly, whereas the posterior palate shelf length is unaffected (J:181120)
• mutants exhibit delayed palatal shelf elongation (J:181120)
• some E15.5 mutants show delayed palate shelf apposition and the persistence of the epithelial seam, however palate fusion occurs in all mutants (J:181120)
• at E14.5, palatal shelf elevation above the tongue occurs normally but palatal elongation is reduced anteriorly, whereas the posterior palate shelf length is unaffected (J:181120)
• mutants exhibit delayed palatal shelf elongation (J:181120)
• some E15.5 mutants show delayed palate shelf apposition and the persistence of the epithelial seam, however palate fusion occurs in all mutants (J:181120)
• palate shelf height is reduced in both the anterior and posterior regions (J:181120)
• palate shelf height is reduced in both the anterior and posterior regions (J:181120)
• midfacial hypoplasia resulting in a reduction in anterior facial width (J:181120)
• midfacial hypoplasia resulting in a reduction in anterior facial width (J:181120)

skeleton
• shortened maxillary regions; anterior-posterior facial length is normal at P0 but over time the mutants exhibit smaller maxillary lengths (J:181120)
• the inframaxillary length and the posterior-anterior length are reduced (J:181120)
• shortened maxillary regions; anterior-posterior facial length is normal at P0 but over time the mutants exhibit smaller maxillary lengths (J:181120)
• the inframaxillary length and the posterior-anterior length are reduced (J:181120)
• dental occlusion is misaligned with severe midface hypoplasia requiring trimming of the lower incisors weekly (J:181120)
• dental occlusion is misaligned with severe midface hypoplasia requiring trimming of the lower incisors weekly (J:181120)

behavior/neurological
• mutants exhibit poor feeding after 30 days of age due to malocclusion and require soft mouse chow (J:181120)
• mutants exhibit poor feeding after 30 days of age due to malocclusion and require soft mouse chow (J:181120)

cardiovascular system
• mutants exhibit aberrant vascular pattering in the palate; reduced vascular branching in the palate at E14.5 and E15.5, reduced vasculature organization and vessel size, poor vascular smooth muscle investment, and irregular vessel formation (J:181120)
• mutants exhibit aberrant vascular pattering in the palate; reduced vascular branching in the palate at E14.5 and E15.5, reduced vasculature organization and vessel size, poor vascular smooth muscle investment, and irregular vessel formation (J:181120)

digestive/alimentary system
• the palatal dimensions are proportionally smaller, however the structural components are in tact (J:181120)
• mutants exhibit reduced proliferation in the palate shelves at E14.5 and in the adjacent palatal epithelium (J:181120)
• mutants exhibit reduced hyaluronic acid in the palate shelves at E14.5 (J:181120)
• mutants exhibit aberrant vascular pattering in the palate including reduced vascular branching at E14.5 and E15.5 (J:181120)
• the palatal dimensions are proportionally smaller, however the structural components are in tact (J:181120)
• mutants exhibit reduced proliferation in the palate shelves at E14.5 and in the adjacent palatal epithelium (J:181120)
• mutants exhibit reduced hyaluronic acid in the palate shelves at E14.5 (J:181120)
• mutants exhibit aberrant vascular pattering in the palate including reduced vascular branching at E14.5 and E15.5 (J:181120)
• at E14.5, palatal shelf elevation above the tongue occurs normally but palatal elongation is reduced anteriorly, whereas the posterior palate shelf length is unaffected (J:181120)
• mutants exhibit delayed palatal shelf elongation (J:181120)
• some E15.5 mutants show delayed palate shelf apposition and the persistence of the epithelial seam, however palate fusion occurs in all mutants (J:181120)
• at E14.5, palatal shelf elevation above the tongue occurs normally but palatal elongation is reduced anteriorly, whereas the posterior palate shelf length is unaffected (J:181120)
• mutants exhibit delayed palatal shelf elongation (J:181120)
• some E15.5 mutants show delayed palate shelf apposition and the persistence of the epithelial seam, however palate fusion occurs in all mutants (J:181120)
• palate shelf height is reduced in both the anterior and posterior regions (J:181120)
• palate shelf height is reduced in both the anterior and posterior regions (J:181120)

Mouse Models of Human Disease
OMIM ID Ref(s)
Alagille Syndrome 1; ALGS1 118450 J:181120




Genotype
MGI:4867007
cn3
Allelic
Composition
Jag1tm1Grid/Jag1tm2Grid
Tg(Tagln-cre)1Her/0
Genetic
Background
involves: 129S1/Sv * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jag1tm1Grid mutation (1 available); any Jag1 mutation (8 available)
Jag1tm2Grid mutation (1 available); any Jag1 mutation (8 available)
Tg(Tagln-cre)1Her mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 50% of mutants die by P1 (J:166769)
• 50% of mutants die by P1 (J:166769)
• no mutants survive past P2 (J:166769)
• no mutants survive past P2 (J:166769)

cardiovascular system
• seen in some mutants (J:166769)
• seen in some mutants (J:166769)
• 95% of mutants exhibit patent ductus arteriosus (J:166769)
• 95% of mutants exhibit patent ductus arteriosus (J:166769)
• defects in vascular smooth muscle cell differentiation in the outer layers of the medial wall of the ductus arteriosus and descending aorta at E17.5 when the ductus arteriosus is still patent, however the ascending limb of the aorta and the pulmonary artery trunk have normal vascular smooth muscle cell differentiation (J:166769)
• defects in vascular smooth muscle cell differentiation in the outer layers of the medial wall of the ductus arteriosus and descending aorta at E17.5 when the ductus arteriosus is still patent, however the ascending limb of the aorta and the pulmonary artery trunk have normal vascular smooth muscle cell differentiation (J:166769)

homeostasis/metabolism

muscle
• defects in vascular smooth muscle cell differentiation in the outer layers of the medial wall of the ductus arteriosus and descending aorta at E17.5 when the ductus arteriosus is still patent, however the ascending limb of the aorta and the pulmonary artery trunk have normal vascular smooth muscle cell differentiation (J:166769)
• defects in vascular smooth muscle cell differentiation in the outer layers of the medial wall of the ductus arteriosus and descending aorta at E17.5 when the ductus arteriosus is still patent, however the ascending limb of the aorta and the pulmonary artery trunk have normal vascular smooth muscle cell differentiation (J:166769)

cellular
• 95% of mutants exhibit patent ductus arteriosus (J:166769)
• 95% of mutants exhibit patent ductus arteriosus (J:166769)

Mouse Models of Human Disease
OMIM ID Ref(s)
Patent Ductus Arteriosus 607411 J:166769




Genotype
MGI:4867008
cn4
Allelic
Composition
Jag1tm2Grid/Jag1tm2Grid
Tg(Tek-cre)12Flv/0
Genetic
Background
involves: C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jag1tm2Grid mutation (1 available); any Jag1 mutation (8 available)
Tg(Tek-cre)12Flv mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• die at approximately E10.5 (J:166769)
• die at approximately E10.5 (J:166769)

cardiovascular system
• fail to remodel the primary vascular plexus of the yolk sac to form large blood vessels (J:166769)
• fail to remodel the primary vascular plexus of the yolk sac to form large blood vessels (J:166769)
• non-cell autonomous defects in vascular smooth muscle cell differentiation (J:166769)
• non-cell autonomous defects in vascular smooth muscle cell differentiation (J:166769)

embryogenesis
• fail to remodel the primary vascular plexus of the yolk sac to form large blood vessels (J:166769)
• fail to remodel the primary vascular plexus of the yolk sac to form large blood vessels (J:166769)

homeostasis/metabolism

muscle
• non-cell autonomous defects in vascular smooth muscle cell differentiation (J:166769)
• non-cell autonomous defects in vascular smooth muscle cell differentiation (J:166769)





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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory