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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(mI56i-cre,EGFP)1Kc
transgene insertion 1, Kenneth Campbell
MGI:3609985
Summary 10 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Arxtm1Gldn/Y
Tg(mI56i-cre,EGFP)1Kc/0
involves: 129/Sv * C57BL/6 * CD-1 * FVB/N MGI:3844352
cn2
Arxtm1Gldn/Arx+
Tg(mI56i-cre,EGFP)1Kc/0
involves: 129/Sv * C57BL/6 * CD-1 * FVB/N MGI:3844353
cn3
Mettm1Sst/Mettm1Sst
Tg(mI56i-cre,EGFP)1Kc/0
involves: 129P2/OlaHsd * C57BL/6J * FVB MGI:4950068
cn4
Celsr3tm1Agof/Celsr3tm2Agof
Tg(mI56i-cre,EGFP)1Kc/0
involves: 129P2/OlaHsd * FVB/N MGI:3795743
cn5
Sp8tm2Smb/Sp8tm2Smb
Tg(mI56i-cre,EGFP)1Kc/?
involves: 129S1/Sv * 129X1/SvJ * Black Swiss * FVB/N MGI:4837173
cn6
Slc12a2tm1.1Jheb/Slc12a2tm1.1Jheb
Tg(mI56i-cre,EGFP)1Kc/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N MGI:5538344
cn7
Islr2tm1.1Ddg/Islr2tm2.1Ddg
Tg(mI56i-cre,EGFP)1Kc/0
involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL MGI:5569796
cn8
Smotm2Amc/Smotm2Amc
Tg(mI56i-cre,EGFP)1Kc/?
involves: 129X1/SvJ * FVB/N MGI:3617990
cx9
Glra2tm1.2Lngu/Y
Tg(mI56i-cre,EGFP)1Kc/0
involves: 129S4/SvJae * C57BL/6J * FVB/N * MF1 MGI:5550563
cx10
Glra2tm1.2Lngu/Glra2tm1.2Lngu
Tg(mI56i-cre,EGFP)1Kc/0
involves: 129S4/SvJae * C57BL/6J * FVB/N * MF1 MGI:5550564


Genotype
MGI:3844352
cn1
Allelic
Composition
Arxtm1Gldn/Y
Tg(mI56i-cre,EGFP)1Kc/0
Genetic
Background
involves: 129/Sv * C57BL/6 * CD-1 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arxtm1Gldn mutation (0 available); any Arx mutation (19 available)
Tg(mI56i-cre,EGFP)1Kc mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• fewer than the expected number of male offspring are recovered from litters from crosses between cre-expressing males and Arxtm1Gldn females
• a siginificant number of mutant males die early in the postnatal period

behavior/neurological
• some mice display seizures characterized by whole body flexion or extension movements resembling epileptic spasms
• some mice display arrest of acitivity/freezing seizures
• all adult mice develop spontaneous brief seizures
• all P14-17 mice demonstrate spontaneous seizures consisting of body arching with forelimb clonus and rearing

nervous system
N
• no brain weight or gross morphological differences are detected in adult or P14-17 animals compared to controls
• some mice display seizures characterized by whole body flexion or extension movements resembling epileptic spasms
• some mice display arrest of acitivity/freezing seizures
• all adult mice develop spontaneous brief seizures
• all P14-17 mice demonstrate spontaneous seizures consisting of body arching with forelimb clonus and rearing
• a prominent reduction in calbindin-labeled neurons in the neocortex compared to controls in the hippocampus, pattern of staining of interneurons is altered from cell body staining to mainly staining interneuron processes
• smaller reductions are observed in numbers and distribution of calretinin-labeled neurons compared to controls
• in P90-120 day-old mice, EEG is disrupted compared to controls; mice display pattern of moderate to higher amplitude and faster frequency activity
• abnormal activity is more apparent in the hippocampal rather than cortical electrodes
• adult animals show a lack of normal 4-7 Hz rhythmic theta activity while awake; hippocampal theta activity is rarely recorded, but when present has faster activity superimposed on the normal theta
• while sleeping, a lack of normal delta power and rhythmic delta activity seen in controls
• mice have a decrease in delta activity and an increase in faster frequency activity
• P14-17 animals display EEGs with slower background with lower voltage than mature controls; one animal showed infrequent large amplitude spikes




Genotype
MGI:3844353
cn2
Allelic
Composition
Arxtm1Gldn/Arx+
Tg(mI56i-cre,EGFP)1Kc/0
Genetic
Background
involves: 129/Sv * C57BL/6 * CD-1 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arxtm1Gldn mutation (0 available); any Arx mutation (19 available)
Tg(mI56i-cre,EGFP)1Kc mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• some adult mice develop convulsive Racine stage 5 seizures
• some adult mice display epileptic spasm seizures
• some adult mice display arrest of acitivity/freezing seizures
• about half of adult female mice develop spontaneous brief seizures of various types
• P14-17 mice develop seizures at a similar rate to adult females; no epileptic spasm seizures are recorded in mice at this ages

nervous system
N
• no brain weight or gross morphological differences are detected in adult or P14-17 animals compared to controls
• some adult mice develop convulsive Racine stage 5 seizures
• some adult mice display epileptic spasm seizures
• some adult mice display arrest of acitivity/freezing seizures
• about half of adult female mice develop spontaneous brief seizures of various types
• P14-17 mice develop seizures at a similar rate to adult females; no epileptic spasm seizures are recorded in mice at this ages
• a prominent reduction in calbindin-labeled neurons in the neocortex compared to controls in the hippocampus, pattern of staining of interneurons is altered from cell body staining to mainly staining interneuron processes
• a significant reduction is observed in numbers and distribution of calretinin-labeled neurons compared to controls
• EEGs of female mice exhibit abnormal background activity; EEG is periodically interrupted by longer runs of higher amplitude, faster rhythms, and demonstrates excessive sharp activity
• females show no decrease in Delta band activity, but do exhibit an increase in faster frequency activity like male mutants




Genotype
MGI:4950068
cn3
Allelic
Composition
Mettm1Sst/Mettm1Sst
Tg(mI56i-cre,EGFP)1Kc/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mettm1Sst mutation (1 available); any Met mutation (28 available)
Tg(mI56i-cre,EGFP)1Kc mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• in the Morris water maze, mutants have a longer latency to locate the platform on the first 2 days of training than controls, however performance on the probe test and reversal probe test were normal, indicating normal hippocampal-mediated spatial learning
• open field activity and anxiety are not affected
• on reversal discriminations, mutants require more trials than controls, indicating impaired reversal learning
• mutants show increased latency performance on the cued-platform test, indicating a delay in striatal-dependent cued learning

nervous system
• marker analysis indicates an increase in numbers of PV+ and SST+ striatal GABAergic interneurons
• distribution of striatal interneurons is altered, with fewer cells of the population located in the medial (associative) regions and more cells in the lateral (sensorimotor) areas
• reduction in the numbers of PV+ GABAergic interneurons in the primary somatosensory cortex (28% loss) and the orbitofrontal cortex (31% loss)
• marker analysis indicates an increase in numbers of PV+ and SST+ striatal GABAergic interneurons
• however, striatum appears normal
• 31% reduction in PV+ cells in the orbitofrontal cortex
• 28% loss of PV+ cells in primary somatosensory cortex




Genotype
MGI:3795743
cn4
Allelic
Composition
Celsr3tm1Agof/Celsr3tm2Agof
Tg(mI56i-cre,EGFP)1Kc/0
Genetic
Background
involves: 129P2/OlaHsd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Celsr3tm1Agof mutation (0 available); any Celsr3 mutation (43 available)
Celsr3tm2Agof mutation (0 available); any Celsr3 mutation (43 available)
Tg(mI56i-cre,EGFP)1Kc mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• the thalamocortical axons aberrantly run through the pallidum and amygdala
• while corticofugal fibers cross the pallial-subpallial boundary and enter the lateral part of the basal forebrain, they fail to progress and spiral in a disordered manner
• both corticothalamic and thalamocortial axons are abnormal




Genotype
MGI:4837173
cn5
Allelic
Composition
Sp8tm2Smb/Sp8tm2Smb
Tg(mI56i-cre,EGFP)1Kc/?
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * Black Swiss * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sp8tm2Smb mutation (1 available); any Sp8 mutation (17 available)
Tg(mI56i-cre,EGFP)1Kc mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• most mice do not exhibit exencephaly
• stacked arrangement of glomeruli
• noticably smaller




Genotype
MGI:5538344
cn6
Allelic
Composition
Slc12a2tm1.1Jheb/Slc12a2tm1.1Jheb
Tg(mI56i-cre,EGFP)1Kc/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc12a2tm1.1Jheb mutation (0 available); any Slc12a2 mutation (23 available)
Tg(mI56i-cre,EGFP)1Kc mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• no behavioral abnormalities are detected




Genotype
MGI:5569796
cn7
Allelic
Composition
Islr2tm1.1Ddg/Islr2tm2.1Ddg
Tg(mI56i-cre,EGFP)1Kc/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Islr2tm1.1Ddg mutation (1 available); any Islr2 mutation (16 available)
Islr2tm2.1Ddg mutation (1 available); any Islr2 mutation (16 available)
Tg(mI56i-cre,EGFP)1Kc mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• some mice die during the fourth postnatal week

nervous system
• thalamic projections are misrouted into the ventral midbrain and tangled within the hypothalamus and near complete absence of corticofugal and thalamocortical axons that cross the pallial-subpallial boundary unlike in wild-type mice
• at P7, pallium and subpallium are nearly completely disconnected
• disorganized with partially formed rostral part of the tract




Genotype
MGI:3617990
cn8
Allelic
Composition
Smotm2Amc/Smotm2Amc
Tg(mI56i-cre,EGFP)1Kc/?
Genetic
Background
involves: 129X1/SvJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smotm2Amc mutation (1 available); any Smo mutation (19 available)
Tg(mI56i-cre,EGFP)1Kc mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• viable with no gross phenotype
• cortical interneuron profiles are normal




Genotype
MGI:5550563
cx9
Allelic
Composition
Glra2tm1.2Lngu/Y
Tg(mI56i-cre,EGFP)1Kc/0
Genetic
Background
involves: 129S4/SvJae * C57BL/6J * FVB/N * MF1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Glra2tm1.2Lngu mutation (0 available); any Glra2 mutation (8 available)
Tg(mI56i-cre,EGFP)1Kc mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• fewer GFP+ cortical interneurons migrating into the cortical wall at E15.5
• however, only neurons traveling in the subventricular zone migratory stream
• fewer GFP+ cortical interneurons migrating into the cortical wall at E15.5
• however, only neurons traveling in the subventricular zone migratory stream

cellular
• fewer GFP+ cortical interneurons migrating into the cortical wall at E15.5
• however, only neurons traveling in the subventricular zone migratory stream




Genotype
MGI:5550564
cx10
Allelic
Composition
Glra2tm1.2Lngu/Glra2tm1.2Lngu
Tg(mI56i-cre,EGFP)1Kc/0
Genetic
Background
involves: 129S4/SvJae * C57BL/6J * FVB/N * MF1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Glra2tm1.2Lngu mutation (0 available); any Glra2 mutation (8 available)
Tg(mI56i-cre,EGFP)1Kc mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• fewer GFP+ cortical interneurons migrating into the cortical wall at E15.5
• however, only neurons traveling in the subventricular zone migratory stream
• fewer GFP+ cortical interneurons migrating into the cortical wall at E15.5
• however, only neurons traveling in the subventricular zone migratory stream

cellular
• fewer GFP+ cortical interneurons migrating into the cortical wall at E15.5
• however, only neurons traveling in the subventricular zone migratory stream





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last database update
03/21/2017
MGI 6.08
The Jackson Laboratory