Arid1b^{tm1c(EUCOMM)Hmgu}
Targeted Allele Detail

Summary

• Symbol: Arid1b^{tm1c(EUCOMM)Hmgu}
• Name: AT-rich interaction domain 1B; targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH
• MGI ID: MGI:6115546
• Gene: Arid1b Location: Chr17:5044607-5397931 bp, + strand Genetic Position: Chr17, 2.83 cM
• Alliance: Arid1b^{tm1c(EUCOMM)Hmgu} page
• IMPC: Arid1b gene page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:256001
• Parent Cell Line: JM8.N4 (ES Cell)
• Strain of Origin: C57BL/6N
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The L1L2_Bact_P cassette was inserted at position 5292502 of Chromosome 17 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 5293746. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele to remove the lacZ sequence and neo selection cassette, leaving loxP sites flanking the critical exon(s). (J:256001)

Expression

In Mice Carrying this Mutation:	2 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Arid1b Mutation: 106 strains or lines available

References

• Original: J:256001 Jung EM, et al., Arid1b haploinsufficiency disrupts cortical interneuron development and mouse behavior. Nat Neurosci. 2017 Dec;20(12):1694-1707
• All: 5 reference(s)