Phenotypes associated with this allele

• Allele Symbol: Arid1b^{tm1c(EUCOMM)Hmgu}
• Allele Name: targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH
• Allele ID: MGI:6115546
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Arid1b^tm1c(EUCOMM)Hmgu/Arid1b^+ Tg(Nkx2-1-cre)2Sand/0	involves: C57BL/6 * C57BL/6N	MGI:8233487
cn2	Arid1b^tm1c(EUCOMM)Hmgu/Arid1b^+ Tg(mI56i-cre,-EGFP)1Kc/0	involves: C57BL/6N * FVB/N	MGI:8233484

Genotype
MGI:8233487

cn1

• Allelic Composition: Arid1b^{tm1c(EUCOMM)Hmgu}/Arid1b⁺; Tg(Nkx2-1-cre)2Sand/0
• Genetic Background: involves: C57BL/6 * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

increased grooming behavior ( J:256001 )

nervous system

abnormal brain interneuron morphology ( J:256001 )

• densities of GABA+ and parvalbumin+ neurons are decreased in the cortices

Genotype
MGI:8233484

cn2

• Allelic Composition: Arid1b^{tm1c(EUCOMM)Hmgu}/Arid1b⁺; Tg(mI56i-cre,-EGFP)1Kc/0
• Genetic Background: involves: C57BL/6N * FVB/N

behavior/neurological

abnormal object recognition memory ( J:256001 )

• in the novel object recognition test, mice do not show any preference for exploring either familiar or novel objects indicating impaired recognition memory

increased anxiety-related response ( J:256001 )

• in the elevated plus maze, mice show increased anxiety

decreased social novelty preference ( J:256001 )

• in the social novelty test, mice spend more time in the chamber containing the first, more familiar, mouse than the second unfamiliar mouse

increased grooming behavior ( J:256001 )

decreased social investigation ( J:256001 )

• in the three-chamber social test, mice show no preference for either chamber

nervous system

abnormal brain interneuron morphology ( J:256001 )

• densities of GABA+ and parvalbumin+ neurons are decreased in the cortices

• number of EGFP+ interneurons is reduced in cortices at E12.5, E14.5, and E18.5

• the length and number of interneuron neurites are decreased in P91 mice

• however, no substantial differences in migration speed of interneurons on E13.5 cortical slices from E13.5

abnormal neurite morphology ( J:256001 )

• the length and number of interneuron neurites are decreased in P91 mice