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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Adamts5tm1Dgen
targeted mutation 1, Deltagen
MGI:3604488
Summary 9 genotypes


Genotype
MGI:4418754
hm1
Allelic
Composition
Adamts5tm1Dgen/Adamts5tm1Dgen
Genetic
Background
B6.129P2-Adamts5tm1Dgen/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adamts5tm1Dgen mutation (1 available); any Adamts5 mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
limbs/digits/tail
• 44% penetrance of soft-tissue syndactyly (STS)
• hindlimbs are more frequently affected




Genotype
MGI:4418860
cx2
Allelic
Composition
Adamts5tm1Dgen/Adamts5tm1Dgen
Adamts9tm1Dgen/Adamts9+
Genetic
Background
B6.129P2-Adamts9tm1Dgen Adamts5tm1Dgen
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adamts5tm1Dgen mutation (1 available); any Adamts5 mutation (4 available)
Adamts9tm1Dgen mutation (0 available); any Adamts9 mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
limbs/digits/tail
• 87% penetrance of soft-tissue syndactyly (STS)




Genotype
MGI:4418759
cx3
Allelic
Composition
Adamts20bt-Bei1/Adamts20+
Adamts5tm1Dgen/Adamts5+
Genetic
Background
B6.Cg-Adamts20bt-Bei1 Adamts5tm1Dgen
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adamts20bt-Bei1 mutation (0 available); any Adamts20 mutation (8 available)
Adamts5tm1Dgen mutation (1 available); any Adamts5 mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
limbs/digits/tail
• partial penetrance of soft-tissue syndactyly (STS)




Genotype
MGI:4418858
cx4
Allelic
Composition
Adamts20bt-Bei1/Adamts20bt-Bei1
Adamts5tm1Dgen/Adamts5tm1Dgen
Genetic
Background
B6.Cg-Adamts20bt-Bei1 Adamts5tm1Dgen
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adamts20bt-Bei1 mutation (0 available); any Adamts20 mutation (8 available)
Adamts5tm1Dgen mutation (1 available); any Adamts5 mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
limbs/digits/tail
• reduced apoptosis compared to wild-type controls in TUNEL and acridine orange stained E14.5 autopods sections
• decreased staining being most evident in IDT between digits 2 and 3 and between digits 3 and 4 of the hindlimbs
• local application of BMP4 or versican fragment induces apoptosis in the IDT in the mutant
• soft-tissue syndactyly (STS) with 100% penetrance
• at least three of four limbs are involved
• the interdigital tissue (IDT) between hindlimb digits 3 and 4 is most frequently involved and has the greatest severity of STS
• persistence of the IDT with a low cell density and loose, amorphous matrix
• reduced versican clearance
• syndactyly is caused by the persistence of the skin web between the digits
• no osseous syndactyly or patterning defects

cellular
• reduced apoptosis compared to wild-type controls in TUNEL and acridine orange stained E14.5 autopods sections
• decreased staining being most evident in IDT between digits 2 and 3 and between digits 3 and 4 of the hindlimbs
• local application of BMP4 or versican fragment induces apoptosis in the IDT in the mutant




Genotype
MGI:4418757
cx5
Allelic
Composition
Adamts20bt-Bei1/Adamts20bt-Bei1
Adamts5tm1Dgen/Adamts5+
Genetic
Background
B6.Cg-Adamts20bt-Bei1 Adamts5tm1Dgen
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adamts20bt-Bei1 mutation (0 available); any Adamts20 mutation (8 available)
Adamts5tm1Dgen mutation (1 available); any Adamts5 mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
limbs/digits/tail
• partial penetrance of soft-tissue syndactyly (STS)




Genotype
MGI:4418755
cx6
Allelic
Composition
Adamts20bt-Bei1/Adamts20+
Adamts5tm1Dgen/Adamts5tm1Dgen
Genetic
Background
B6.Cg-Adamts20bt-Bei1 Adamts5tm1Dgen
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adamts20bt-Bei1 mutation (0 available); any Adamts20 mutation (8 available)
Adamts5tm1Dgen mutation (1 available); any Adamts5 mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
limbs/digits/tail
• partial penetrance of soft-tissue syndactyly (STS)




Genotype
MGI:4418865
cx7
Allelic
Composition
Adamts20bt-Bei1/Adamts20+
Adamts5tm1Dgen/Adamts5+
Adamts9tm1Dgen/Adamts9+
Genetic
Background
B6.Cg-Adamts9tm1Dgen Adamts20bt-Bei1 Adamts5tm1Dgen
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adamts20bt-Bei1 mutation (0 available); any Adamts20 mutation (8 available)
Adamts5tm1Dgen mutation (1 available); any Adamts5 mutation (4 available)
Adamts9tm1Dgen mutation (0 available); any Adamts9 mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
limbs/digits/tail
• partial penetrance of soft-tissue syndactyly (STS)




Genotype
MGI:4418861
cx8
Allelic
Composition
Adamts20bt-Bei1/Adamts20+
Adamts5tm1Dgen/Adamts5tm1Dgen
Adamts9tm1Dgen/Adamts9+
Genetic
Background
B6.Cg-Adamts9tm1Dgen Adamts20bt-Bei1 Adamts5tm1Dgen
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adamts20bt-Bei1 mutation (0 available); any Adamts20 mutation (8 available)
Adamts5tm1Dgen mutation (1 available); any Adamts5 mutation (4 available)
Adamts9tm1Dgen mutation (0 available); any Adamts9 mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
limbs/digits/tail
• fully penetrant soft-tissue syndactyly (STS)
• more affected limbs than littermate control




Genotype
MGI:5603313
cx9
Allelic
Composition
Adamts5tm1Dgen/Adamts5tm1Dgen
Adamts9tm1.1Apte/Adamts9tm1.1Apte
Tg(Prrx1-cre)1Cjt/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adamts5tm1Dgen mutation (1 available); any Adamts5 mutation (4 available)
Adamts9tm1.1Apte mutation (1 available); any Adamts9 mutation (8 available)
Tg(Prrx1-cre)1Cjt mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
limbs/digits/tail
• 100% incidence of soft tissue syndactyly
• phenotype is more severe than in either allele alone





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/16/2021
MGI 6.16
The Jackson Laboratory