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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Abca1tm1Jp
targeted mutation 1, John S Parks
MGI:3577723
Summary 8 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Abca1tm1Jp/Abca1tm1Jp
Abcg1tm1Tall/Abcg1tm1Tall
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 MGI:5451017
cn2
Abca1tm1Jp/Abca1+
Tg(Alb-cre)21Mgn/0
involves: 129S6/SvEvTac * B6.Cg-Tg(Alb-cre)21Mgn/J MGI:3578114
cn3
Abca1tm1Jp/Abca1tm1Jp
Tg(Alb-cre)21Mgn/0
involves: 129S6/SvEvTac * B6.Cg-Tg(Alb-cre)21Mgn/J MGI:3578113
cn4
Abca1tm1Jp/Abca1tm1Jp
Abcg1tm1Tall/Abcg1tm1Tall
Tg(Itgax-cre,-EGFP)4097Ach/0
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J MGI:5451018
cn5
Abca1tm1Jp/Abca1tm1Jp
Tg(Alb-cre)21Mgn/0
involves: 129S6/SvEvTac * C57BL/6 * DBA MGI:4358982
cn6
Abca1tm1Jp/Abca1tm1Jp
Tg(Alb-cre)21Mgn/0
Tg(Vil1-cre)997Gum/0
involves: 129S6/SvEvTac * C57BL/6 * DBA * SJL MGI:4358977
cn7
Abca1tm1Jp/Abca1+
Tg(Vil1-cre)997Gum/0
involves: 129S6/SvEvTac * C57BL/6 * SJL MGI:4358974
cn8
Abca1tm1Jp/Abca1tm1Jp
Tg(Vil1-cre)997Gum/0
involves: 129S6/SvEvTac * C57BL/6 * SJL MGI:4358973


Genotype
MGI:5451017
cn1
Allelic
Composition
Abca1tm1Jp/Abca1tm1Jp
Abcg1tm1Tall/Abcg1tm1Tall
Lyz2tm1(cre)Ifo/Lyz2+
Genetic
Background
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abca1tm1Jp mutation (2 available); any Abca1 mutation (43 available)
Abcg1tm1Tall mutation (1 available); any Abcg1 mutation (24 available)
Lyz2tm1(cre)Ifo mutation (7 available); any Lyz2 mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• mice exhibit an increase in colony-forming units in the blood

immune system
• 1.5-fold in the spleen




Genotype
MGI:3578114
cn2
Allelic
Composition
Abca1tm1Jp/Abca1+
Tg(Alb-cre)21Mgn/0
Genetic
Background
involves: 129S6/SvEvTac * B6.Cg-Tg(Alb-cre)21Mgn/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abca1tm1Jp mutation (2 available); any Abca1 mutation (43 available)
Tg(Alb-cre)21Mgn mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• decreased (70-90%) phospholipid levels
• slightly higher catabolism of HDL apoA-I from wildtype mice or human lipid-free ApoA-I than in wildtype, due to an increase in the catabolism of apoA-I by the kidney, with no change in liver catabolism
• decreased levels of total plasma cholesterol, free cholesterol, and esterified cholesterol




Genotype
MGI:3578113
cn3
Allelic
Composition
Abca1tm1Jp/Abca1tm1Jp
Tg(Alb-cre)21Mgn/0
Genetic
Background
involves: 129S6/SvEvTac * B6.Cg-Tg(Alb-cre)21Mgn/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abca1tm1Jp mutation (2 available); any Abca1 mutation (43 available)
Tg(Alb-cre)21Mgn mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• 70-90% reduction in plasma phospholipid level
• 2-fold higher catabolism of HDL apoA-I from wildtype mice or human lipid-free ApoA-I than in wildtype, due to a 2-fold increase in the catabolism of apoA-I by the kidney, with no change in liver catabolism
• total plasma cholesterol levels were 80% lower than in wildtype
• 70-90% reduction in plasma free cholesterol and esterified cholesterol
• 80% lower than in wildtype

Mouse Models of Human Disease
OMIM ID Ref(s)
Tangier Disease; TGD 205400 J:98093




Genotype
MGI:5451018
cn4
Allelic
Composition
Abca1tm1Jp/Abca1tm1Jp
Abcg1tm1Tall/Abcg1tm1Tall
Tg(Itgax-cre,-EGFP)4097Ach/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abca1tm1Jp mutation (2 available); any Abca1 mutation (43 available)
Abcg1tm1Tall mutation (1 available); any Abcg1 mutation (24 available)
Tg(Itgax-cre,-EGFP)4097Ach mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• mice exhibit an increase in colony-forming units in the blood

immune system
• 1.8-fold in the spleen




Genotype
MGI:4358982
cn5
Allelic
Composition
Abca1tm1Jp/Abca1tm1Jp
Tg(Alb-cre)21Mgn/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abca1tm1Jp mutation (2 available); any Abca1 mutation (43 available)
Tg(Alb-cre)21Mgn mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• HDL levels are reduced by 80%




Genotype
MGI:4358977
cn6
Allelic
Composition
Abca1tm1Jp/Abca1tm1Jp
Tg(Alb-cre)21Mgn/0
Tg(Vil1-cre)997Gum/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * DBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abca1tm1Jp mutation (2 available); any Abca1 mutation (43 available)
Tg(Alb-cre)21Mgn mutation (4 available)
Tg(Vil1-cre)997Gum mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• plasma HDL levels are reduced by 90%




Genotype
MGI:4358974
cn7
Allelic
Composition
Abca1tm1Jp/Abca1+
Tg(Vil1-cre)997Gum/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abca1tm1Jp mutation (2 available); any Abca1 mutation (43 available)
Tg(Vil1-cre)997Gum mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• total cholesterol levels are reduced due to decreases in HDL
• fasting plasma HDL levels are reduced about 15%




Genotype
MGI:4358973
cn8
Allelic
Composition
Abca1tm1Jp/Abca1tm1Jp
Tg(Vil1-cre)997Gum/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abca1tm1Jp mutation (2 available); any Abca1 mutation (43 available)
Tg(Vil1-cre)997Gum mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• enterocytes have decreased efflux of cholesterol in vitro
• in vivo, uptake of cholesterol in the gut is unaffected by cholesterol fails to get transported to the circulatory system

digestive/alimentary system
• cholesterol uptaken from the lumen of the gut is retained in the enterocytes instead of being transported to the blood

homeostasis/metabolism
• enterocytes have decreased efflux of cholesterol in vitro
• in vivo, uptake of cholesterol in the gut is unaffected by cholesterol fails to get transported to the circulatory system
• total cholesterol levels are reduced
• fasting plasma HDL levels are reduced about 30%
• serum levels of Apo-AI, Apo-AII and ApoB are also reduced by about 25-35%
• serum levels of Apo-AI, Apo-AII and ApoB are also reduced by about 25-35%





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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory