Phenotypes associated with this allele

• Allele Symbol: Nodal^tm6Rob
• Allele Name: targeted mutation 6, Elizabeth J Robertson
• Allele ID: MGI:3521719
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nodal^tm6Rob/Nodal^tm6Rob	involves: 129S/SvEv * C57BL/6	MGI:3521751
ht2	Nodal^TgR(MPSVNeo)413.dRob/Nodal^tm6Rob	involves: 129S/SvEv * C57BL/6	MGI:3521752

Genotype
MGI:3521751

hm1

• Allelic Composition: Nodal^tm6Rob/Nodal^tm6Rob
• Genetic Background: involves: 129S/SvEv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:94418 )

Genotype
MGI:3521752

ht2

• Allelic Composition: Nodal^{TgR(MPSVNeo)413.dRob}/Nodal^tm6Rob
• Genetic Background: involves: 129S/SvEv * C57BL/6

cardiovascular system

trabecula carnea hypoplasia ( J:94418 )

• the density of trabeculae is decreased compared to controls in 4/12 mutants

thin myocardium compact layer ( J:94418 )

• in 4/12 mutants the compact myocardial layer is thinner

abnormal direction of heart looping ( J:94418 )

• heart looping is reversed in less than 2% of mutants

delayed heart development ( J:94418 )

• cardiac morphogenesis is delayed

common atrium ( J:94418 )

• a common atrium is seen in 3/12 mutants at E13.5

abnormal interventricular septum morphology ( J:94418 )

• at E13.5 ventricular septal wall formation is incomplete in about 42% of mutants

growth/size/body

right pulmonary isomerism ( J:94418 )

• partial right isomerism is seen in 4% of mutant embryos

muscle

trabecula carnea hypoplasia ( J:94418 )

• the density of trabeculae is decreased compared to controls in 4/12 mutants

thin myocardium compact layer ( J:94418 )

• in 4/12 mutants the compact myocardial layer is thinner

respiratory system

right pulmonary isomerism ( J:94418 )

• partial right isomerism is seen in 4% of mutant embryos