All Phenotypes Pax7<tm1(cre)Mrc> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Pax7^tm1(cre)Mrc
targeted mutation 1, Mario R Capecchi
MGI:3497712

Summary

11 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pax7^tm1(cre)Mrc/Pax7^tm1(cre)Mrc	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3510832
cn2	Abcc6^{tm1c(EUCOMM)Wtsi}/Abcc6^{tm1c(EUCOMM)Wtsi} Pax7^tm1(cre)Mrc/?	B6.Cg-Pax7^tm1(cre)Mrc Abcc6^{tm1c(EUCOMM)Wtsi}	MGI:6241508
cn3	Dbx1^tm1(DTA)Apie/Dbx1⁺ Pax7^tm1(cre)Mrc/Pax7⁺	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:4837354
cn4	Ptch1^tm1Cklr/Ptch1⁺ Trp53^tm1Brn/? Pax7^tm1(cre)Mrc/Pax7⁺	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	MGI:4453164
cn5	Myh3^tm1.2Sajm/Myh3^tm1.1Sajm Pax7^tm1(cre)Mrc/Pax7⁺	involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J	MGI:6695908
cn6	Pax7^tm1(cre)Mrc/Pax7^tm1(cre)Mrc Paxbp1^tm1.1Nju/Paxbp1^tm1.1Nju	involves: 129S1/Sv * 129X1/SvJ	MGI:6827450
cn7	Gt(ROSA)26Sor^{tm4(EWSR1/ATF1)Mrc}/Gt(ROSA)26Sor⁺ Pax7^tm1(cre)Mrc/Pax7⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5495314
cn8	Pax3^tm1Mrc/Pax3⁺ Pax7^tm1(cre)Mrc/Pax7⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3510831
cn9	Gt(ROSA)26Sor^tm2(SS18)Mrc/Gt(ROSA)26Sor^tm2(SS18)Mrc Pax7^tm1(cre)Mrc/Pax7^tm1(cre)Mrc	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3710998
cn10	Gt(ROSA)26Sor^{tm3(SS18/EGFP)Mrc}/Gt(ROSA)26Sor^{tm3(SS18/EGFP)Mrc} Pax7^tm1(cre)Mrc/Pax7^tm1(cre)Mrc	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3710999
cn11	Ptch1^tm1Cklr/Ptch1⁺ Pax7^tm1(cre)Mrc/Pax7⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	MGI:4453163

Allelic Composition	Pax7^tm1(cre)Mrc/Pax7^tm1(cre)Mrc
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax7^tm1(cre)Mrc mutation (3 available); any Pax7 mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:93443 )

• homozygotes are normal and fertile

Allelic Composition	Abcc6^{tm1c(EUCOMM)Wtsi}/Abcc6^{tm1c(EUCOMM)Wtsi} Pax7^tm1(cre)Mrc/?
Genetic Background	B6.Cg-Pax7^tm1(cre)Mrc Abcc6^{tm1c(EUCOMM)Wtsi}

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abcc6^{tm1c(EUCOMM)Wtsi} mutation (1 available); any Abcc6 mutation (74 available)
Pax7^tm1(cre)Mrc mutation (3 available); any Pax7 mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

integument phenotype ( J:252837 )

N	• no calcification occurs in the fibrous capsule surrounding the muzzle vibrissae

Allelic Composition	Dbx1^tm1(DTA)Apie/Dbx1⁺ Pax7^tm1(cre)Mrc/Pax7⁺
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dbx1^tm1(DTA)Apie mutation (1 available); any Dbx1 mutation (25 available)
Pax7^tm1(cre)Mrc mutation (3 available); any Pax7 mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:165285 )

N	• at E15.5, rhythmic activity in the pre-Botzinger complex is preserved

Allelic Composition	Ptch1^tm1Cklr/Ptch1⁺ Trp53^tm1Brn/? Pax7^tm1(cre)Mrc/Pax7⁺
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax7^tm1(cre)Mrc mutation (3 available); any Pax7 mutation (39 available)
Ptch1^tm1Cklr mutation (1 available); any Ptch1 mutation (115 available)
Trp53^tm1Brn mutation (18 available); any Trp53 mutation (232 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased medulloblastoma incidence ( J:159972 )

• earlier tumor onset, from 32 to 65 days of age

• bortezomib treated mice have better survival

nervous system

increased medulloblastoma incidence ( J:159972 )

• earlier tumor onset, from 32 to 65 days of age

• bortezomib treated mice have better survival

Allelic Composition	Myh3^tm1.2Sajm/Myh3^tm1.1Sajm Pax7^tm1(cre)Mrc/Pax7⁺
Genetic Background	involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myh3^tm1.1Sajm mutation (0 available); any Myh3 mutation (73 available)
Myh3^tm1.2Sajm mutation (0 available); any Myh3 mutation (73 available)
Pax7^tm1(cre)Mrc mutation (3 available); any Pax7 mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

abnormal muscle precursor cell morphology ( J:287755 )

• reduction in myogenic precursor marker Pax7 peptide level and 50% reduction in Pax7+ myogenic precursor cells in E16.5 embryos

• significantly reduced levels of committed myoblast markers MyoD and myogenin peptide levels and 60% reduction in MyoD+ myoblasts in E16.5 embryos

• 7x increased MyHC-slow peptide levels in E16.5 embryos

cellular

cellular phenotype ( J:287755 )

N	• normal apoptosis in E16.5 embryos

Allelic Composition	Pax7^tm1(cre)Mrc/Pax7^tm1(cre)Mrc Paxbp1^tm1.1Nju/Paxbp1^tm1.1Nju
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax7^tm1(cre)Mrc mutation (3 available); any Pax7 mutation (39 available)
Paxbp1^tm1.1Nju mutation (0 available); any Paxbp1 mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:304562 )

• no live mice born

Allelic Composition	Gt(ROSA)26Sor^{tm4(EWSR1/ATF1)Mrc}/Gt(ROSA)26Sor⁺ Pax7^tm1(cre)Mrc/Pax7⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm4(EWSR1/ATF1)Mrc} mutation (0 available); any Gt(ROSA)26Sor mutation (944 available)
Pax7^tm1(cre)Mrc mutation (3 available); any Pax7 mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:194308 )

• live embryos at E18.5 but no live progeny

craniofacial

abnormal craniofacial morphology ( J:194308 )

• severe craniofacial deformation

Allelic Composition	Pax3^tm1Mrc/Pax3⁺ Pax7^tm1(cre)Mrc/Pax7⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax3^tm1Mrc mutation (1 available); any Pax3 mutation (50 available)
Pax7^tm1(cre)Mrc mutation (3 available); any Pax7 mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:93443 )

• because of breathing difficulties few mutants survive beyond 3.5 months of age

neoplasm

neoplasm ( J:93443 )

N	• no alveolar rhabdomyosarcomas are detected

craniofacial

abnormal premaxilla morphology ( J:93443 )

• agenesis of the rostral premaxilla is seen

maxilla hypoplasia ( J:93443 )

lacrimal bone hypoplasia ( J:93443 )

• hypoplasia of the lacrimal bone is seen

abnormal nose morphology ( J:93443 )

• a narrowed nose is seen

turbinate hypoplasia ( J:93443 )

• the nasal turbinates are underdeveloped

growth/size/body

abnormal nose morphology ( J:93443 )

• a narrowed nose is seen

turbinate hypoplasia ( J:93443 )

• the nasal turbinates are underdeveloped

decreased body weight ( J:93443 )

• at 3 weeks of age mutants weigh less than one-third of wild-type littermates

postnatal growth retardation ( J:93443 )

• severe growth retardation is seen by 3 weeks of age

muscle

decreased skeletal muscle fiber diameter ( J:93443 )

• myofiber diameter is reduced

decreased skeletal muscle mass ( J:93443 )

• muscle mass is reduced

decreased satellite cell number ( J:93443 )

• the number of satellite cells is reduced

increased skeletal muscle fiber density ( J:93443 )

• myofiber density is increased

muscle hypoplasia ( J:93443 )

respiratory system

abnormal nose morphology ( J:93443 )

• a narrowed nose is seen

turbinate hypoplasia ( J:93443 )

• the nasal turbinates are underdeveloped

skeleton

abnormal premaxilla morphology ( J:93443 )

• agenesis of the rostral premaxilla is seen

maxilla hypoplasia ( J:93443 )

lacrimal bone hypoplasia ( J:93443 )

• hypoplasia of the lacrimal bone is seen

turbinate hypoplasia ( J:93443 )

• the nasal turbinates are underdeveloped

Allelic Composition	Gt(ROSA)26Sor^tm2(SS18)Mrc/Gt(ROSA)26Sor^tm2(SS18)Mrc Pax7^tm1(cre)Mrc/Pax7^tm1(cre)Mrc
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^tm2(SS18)Mrc mutation (0 available); any Gt(ROSA)26Sor mutation (944 available)
Pax7^tm1(cre)Mrc mutation (3 available); any Pax7 mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:120967 )

• no live embryos are recovered

Allelic Composition	Gt(ROSA)26Sor^{tm3(SS18/EGFP)Mrc}/Gt(ROSA)26Sor^{tm3(SS18/EGFP)Mrc} Pax7^tm1(cre)Mrc/Pax7^tm1(cre)Mrc
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm3(SS18/EGFP)Mrc} mutation (0 available); any Gt(ROSA)26Sor mutation (944 available)
Pax7^tm1(cre)Mrc mutation (3 available); any Pax7 mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:120967 )

• no pups are born but they can be recovered at E15.5

muscle

abnormal muscle development ( J:120967 )

• Pax7+ lineage cells are mostly absent except in the proximity to cartilaginous regions of the developing maxilla and nasal turbinates

Allelic Composition	Ptch1^tm1Cklr/Ptch1⁺ Pax7^tm1(cre)Mrc/Pax7⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

ataxia ( J:159972 )

• 9 of 30 double heterozygous mice become ataxic starting around 88-100 days of age

neoplasm

increased medulloblastoma incidence ( J:159972 )

• tumors invade the subarachnoid space

• evidence of leptomeningeal metastasis

• all ataxic mice have rapidly growing tumors in the cerebellum

• high nuclear to cytoplasm ratio in tumor cells

nervous system

increased medulloblastoma incidence ( J:159972 )

• all ataxic mice have rapidly growing tumors in the cerebellum

• high nuclear to cytoplasm ratio in tumor cells

• tumors invade the subarachnoid space

• evidence of leptomeningeal metastasis

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