Myh3^tm1.1Sajm
Targeted Allele Detail

Summary

• Symbol: Myh3^tm1.1Sajm
• Name: myosin, heavy polypeptide 3, skeletal muscle, embryonic; targeted mutation 1.1, Sam J Mathew
• MGI ID: MGI:6695298
• Synonyms: Myh3^fl3-7
• Gene: Myh3 Location: Chr11:66969126-66993112 bp, + strand Genetic Position: Chr11, 40.59 cM
• Alliance: Myh3^tm1.1Sajm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:287755
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted into intron 2 and an FRT site flanked neomycin resistance gene cassette and a second loxP site into intron 7. The neo cassette was removed through subsequent flp-mediated recombination, leaving a conditional-ready allele with exons 3-7 floxed. (J:287755)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Myh3 Mutation: 73 strains or lines available

References

• Original: J:287755 Agarwal M, et al., Myosin heavy chain-embryonic regulates skeletal muscle differentiation during mammalian development. Development. 2020 Apr 6;147(7):dev184507
• All: 1 reference(s)