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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tnfrsf13ctm1Mass
targeted mutation 1, Marc Schmidt-Supprian
MGI:3054891
Summary 12 genotypes


Genotype
MGI:3055132
hm1
Allelic
Composition
Tnfrsf13ctm1Mass/Tnfrsf13ctm1Mass
Genetic
Background
C57BL/6-Tnfrsf13ctm1Mass
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfrsf13ctm1Mass mutation (1 available); any Tnfrsf13c mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• a block in B cell development from IgM+ (T1 + T2) to IgMlow (T3) cells is seen
• the number of mature recirculating B cells is reduced with about a 10-fold reduction in IgD+ B cells in the bone marrow and a 20-fold decrease in IgMlowIgD+ B cells in the lymph nodes
• a reduction in peritoneal B2 cells but not B1 cells is seen
• there is about a third reduction in the number of B cells that survive 36 hours of in vitro culturing compared to controls
• addition of Tnfsf13b (BAFF) to the culture does not elevate survival
• the titers of IgG1, IgG2a, IgG2b, and IgG3 are reduced
• immunization with NP-CG produces a significantly smaller increase in IgG1 titers in mutants compared to wild-type mice and no secondary NP-specific response is detected in mutants
• immunization with NP-Ficoll produces a smaller increase in IgG3 titers in mutants compared to wild-type mice
• the titer of IgM but not IgA is reduced compared to wild-type mice
• immunization with NP-Ficoll produces a smaller increase in IgM titers in mutants compared to wild-type mice

immune system
• a block in B cell development from IgM+ (T1 + T2) to IgMlow (T3) cells is seen
• the number of mature recirculating B cells is reduced with about a 10-fold reduction in IgD+ B cells in the bone marrow and a 20-fold decrease in IgMlowIgD+ B cells in the lymph nodes
• a reduction in peritoneal B2 cells but not B1 cells is seen
• there is about a third reduction in the number of B cells that survive 36 hours of in vitro culturing compared to controls
• addition of Tnfsf13b (BAFF) to the culture does not elevate survival
• the titers of IgG1, IgG2a, IgG2b, and IgG3 are reduced
• immunization with NP-CG produces a significantly smaller increase in IgG1 titers in mutants compared to wild-type mice and no secondary NP-specific response is detected in mutants
• immunization with NP-Ficoll produces a smaller increase in IgG3 titers in mutants compared to wild-type mice
• the titer of IgM but not IgA is reduced compared to wild-type mice
• immunization with NP-Ficoll produces a smaller increase in IgM titers in mutants compared to wild-type mice




Genotype
MGI:3809752
hm2
Allelic
Composition
Tnfrsf13ctm1Mass/Tnfrsf13ctm1Mass
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfrsf13ctm1Mass mutation (1 available); any Tnfrsf13c mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype



Genotype
MGI:3687509
cn3
Allelic
Composition
Cd19tm1(cre)Cgn/Cd19+
Gt(ROSA)26Sortm4(Ikbkb)Rsky/Gt(ROSA)26Sor+
Tnfrsf13ctm1Mass/Tnfrsf13ctm1Mass
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (8 available); any Cd19 mutation (15 available)
Gt(ROSA)26Sortm4(Ikbkb)Rsky mutation (1 available); any Gt(ROSA)26Sor mutation (523 available)
Tnfrsf13ctm1Mass mutation (1 available); any Tnfrsf13c mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• normal numbers of mature B cells including follicular and marginal zone B cells are produced
• spleens contain well-organized lymphoid architecture with normal follicles and distinct marginal zone




Genotype
MGI:3809750
cn4
Allelic
Composition
Cd19tm1(cre)Cgn/Cd19+
Gt(ROSA)26Sortm5(Map3k14)Rsky/Gt(ROSA)26Sortm5(Map3k14)Rsky
Tnfrsf13ctm1Mass/Tnfrsf13ctm1Mass
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (8 available); any Cd19 mutation (15 available)
Gt(ROSA)26Sortm5(Map3k14)Rsky mutation (1 available); any Gt(ROSA)26Sor mutation (523 available)
Tnfrsf13ctm1Mass mutation (1 available); any Tnfrsf13c mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype



Genotype
MGI:3809751
cn5
Allelic
Composition
Cd19tm1(cre)Cgn/Cd19+
Gt(ROSA)26Sortm6(Map3k14*)Rsky/Gt(ROSA)26Sortm6(Map3k14*)Rsky
Tnfrsf13ctm1Mass/Tnfrsf13ctm1Mass
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (8 available); any Cd19 mutation (15 available)
Gt(ROSA)26Sortm6(Map3k14*)Rsky mutation (1 available); any Gt(ROSA)26Sor mutation (523 available)
Tnfrsf13ctm1Mass mutation (1 available); any Tnfrsf13c mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype



Genotype
MGI:5013718
cn6
Allelic
Composition
Birc2tm1Rbr/Birc2tm1Rbr
Birc3tm1.1Rbr/Birc3tm1.1Rbr
Cd19tm1(cre)Cgn/Cd19+
Tnfrsf13ctm1Mass/Tnfrsf13ctm1Mass
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * NZB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Birc2tm1Rbr mutation (0 available); any Birc2 mutation (6 available)
Birc3tm1.1Rbr mutation (0 available); any Birc3 mutation (7 available)
Cd19tm1(cre)Cgn mutation (8 available); any Cd19 mutation (15 available)
Tnfrsf13ctm1Mass mutation (1 available); any Tnfrsf13c mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• mice exhibit normal B cell development in the spleen and lymph node unlike in Tnfrsf13ctm1Mass homozygotes




Genotype
MGI:3841115
cx7
Allelic
Composition
Tg(Tnfsf13b)1Fma/?
Tnfrsf13ctm1Mass/Tnfrsf13ctm1Mass
Genetic
Background
B6.Cg-Tnfrsf13ctm1Mass Tg(Tnfsf13b)1Fma
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Tnfsf13b)1Fma mutation (0 available)
Tnfrsf13ctm1Mass mutation (1 available); any Tnfrsf13c mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• class switch recombination mediated by BAFF incubation is defective in these mice

immune system
• class switch recombination mediated by BAFF incubation is defective in these mice




Genotype
MGI:5013719
cx8
Allelic
Composition
Cd19tm1(cre)Cgn/Cd19+
Tnfrsf13ctm1Mass/Tnfrsf13ctm1Mass
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (8 available); any Cd19 mutation (15 available)
Tnfrsf13ctm1Mass mutation (1 available); any Tnfrsf13c mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• in the spleen and lymph node

immune system
• in the spleen and lymph node




Genotype
MGI:3760856
cx9
Allelic
Composition
Ightm1.2Rsky/Igh+
Tnfrsf13ctm1Mass/Tnfrsf13ctm1Mass
Genetic
Background
involves: BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ightm1.2Rsky mutation (0 available); any Igh mutation (36 available)
Tnfrsf13ctm1Mass mutation (1 available); any Tnfrsf13c mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• four fold reduction of mature B cells in the spleen

hematopoietic system
• four fold reduction of mature B cells in the spleen




Genotype
MGI:5013720
cx10
Allelic
Composition
Tnfrsf13ctm1Mass/Tnfrsf13ctm1Mass
Traf2tm1Rbr/Traf2tm1Rbr
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfrsf13ctm1Mass mutation (1 available); any Tnfrsf13c mutation (7 available)
Traf2tm1Rbr mutation (0 available); any Traf2 mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• mice exhibit normal B cell development in the spleen and lymph node unlike in Tnfrsf13ctm1Mass homozygotes
• in response to CD40L, mice exhibit 5-fold lower germinal center B cells compared with wild-type mice
• in response to CD40L

hematopoietic system
• in response to CD40L, mice exhibit 5-fold lower germinal center B cells compared with wild-type mice
• in response to CD40L




Genotype
MGI:5013721
cx11
Allelic
Composition
Tnfrsf13ctm1Mass/Tnfrsf13ctm1Mass
Traf3tm1Rbr/Traf3tm1Rbr
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfrsf13ctm1Mass mutation (1 available); any Tnfrsf13c mutation (7 available)
Traf3tm1Rbr mutation (0 available); any Traf3 mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• mice exhibit normal B cell development in the spleen and lymph node unlike in Tnfrsf13ctm1Mass homozygotes




Genotype
MGI:3687507
cx12
Allelic
Composition
Tnfrsf13ctm1Mass/Tnfrsf13ctm1Mass
Tg(BCL2)22Wehi/0
Genetic
Background
involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(BCL2)22Wehi mutation (2 available)
Tnfrsf13ctm1Mass mutation (1 available); any Tnfrsf13c mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism

immune system
N
• B cell development is normal in these mutants unlike Tnfrsf13ctm1Mass homozygotes





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last database update
03/24/2020
MGI 6.15
The Jackson Laboratory