Gt(ROSA)26Sortm6(Map3k14*)Rsky
Targeted Allele Detail
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Symbol: |
Gt(ROSA)26Sortm6(Map3k14*)Rsky |
Name: |
gene trap ROSA 26, Philippe Soriano; targeted mutation 6, Klaus Rajewsky |
MGI ID: |
MGI:3809723 |
Synonyms: |
R26StopFLNikdeltaT3 |
Gene: |
Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
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Alliance: |
Gt(ROSA)26Sortm6(Map3k14*)Rsky page
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Germline Transmission: |
Earliest citation of germline transmission:
J:139293
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Parent Cell Line: |
Bruce 4 (ES Cell)
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Strain of Origin: |
B6.Cg-Thy1a
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Allele Type: |
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Targeted (Conditional ready, Inserted expressed sequence, Reporter) |
Mutation: |
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Insertion
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Gt(ROSA)26Sortm6(Map3k14*)Rsky expresses
1 gene
Knock-in expresses:
Organism |
Expressed Gene |
Note |
mouse |
Map3k14 (MGI:1858204) |
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Mutation details: The gene lacking the sequence that encodes the TRAF3-binding domain, preceded by a floxed neo STOP cassette and followed by an frt-flanked IRES-EGFP cassette, was knocked into the locus to achieve cre-inducible, ubiquitous expression. Cre mediated removal of the STOP cassette is required for expression.
(J:139293, J:157820)
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View phenotypes and curated references for all genotypes (concatenated display).
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Original: |
J:139293 Sasaki Y, et al., NIK overexpression amplifies, whereas ablation of its TRAF3-binding domain replaces BAFF:BAFF-R-mediated survival signals in B cells. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10883-8 |
All: |
11 reference(s) |
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