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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(PLADA)4118Rkmb
transgene insertion 4118, Michael R Blackburn
MGI:2683027
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Adatm1Mw/Adatm1Mw
Tg(PLADA)4118Rkmb/0
involves: 129S7/SvEvBrd * C57BL/6 MGI:2683994


Genotype
MGI:2683994
cx1
Allelic
Composition
Adatm1Mw/Adatm1Mw
Tg(PLADA)4118Rkmb/0
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adatm1Mw mutation (3 available); any Ada mutation (9 available)
Tg(PLADA)4118Rkmb mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Structural alterations in the thymus and spleen of Adatm1Mw/Adatm1Mw Tg(PLADA)4118Rkmb/0 mice

mortality/aging
• death by 3 weeks of age (J:73418)
• death by 3 weeks of age (J:73418)

hematopoietic system
• with decreased cortical-medullary demarcation (J:73418)
• with decreased cortical-medullary demarcation (J:73418)
• in thymus (J:73418)
• in thymus (J:73418)
• in both thymus and spleen (J:73418)
• in both thymus and spleen (J:73418)
• with decreased numbers of red blood cells and few megakaryocytes observed (J:73418)
• with decreased numbers of red blood cells and few megakaryocytes observed (J:73418)
• lymphoid counts substantially reduced (J:73418)
• lymphoid counts substantially reduced (J:73418)

immune system
• with decreased cortical-medullary demarcation (J:73418)
• with decreased cortical-medullary demarcation (J:73418)
• in thymus (J:73418)
• in thymus (J:73418)
• in both thymus and spleen (J:73418)
• in both thymus and spleen (J:73418)
• with decreased numbers of red blood cells and few megakaryocytes observed (J:73418)
• with decreased numbers of red blood cells and few megakaryocytes observed (J:73418)
• lymphoid counts substantially reduced (J:73418)
• lymphoid counts substantially reduced (J:73418)
• evidence of inflammatory cells, thickening and shedding of airway epithelium and occlusion of airways with mucous and cellular debris (J:73418)
• evidence of inflammatory cells, thickening and shedding of airway epithelium and occlusion of airways with mucous and cellular debris (J:73418)

renal/urinary system
• increased red blood cells within glomeruli (J:73418)
• increased red blood cells within glomeruli (J:73418)
• increased red blood cells within convoluted tubules (J:73418)
• increased red blood cells within convoluted tubules (J:73418)

respiratory system
• evidence of inflammatory cells, thickening and shedding of airway epithelium and occlusion of airways with mucous and cellular debris (J:73418)
• evidence of inflammatory cells, thickening and shedding of airway epithelium and occlusion of airways with mucous and cellular debris (J:73418)
• evident beginning at postnatal day 12 and progressively labored breathing until death (J:73418)
• evident beginning at postnatal day 12 and progressively labored breathing until death (J:73418)

skeleton
• enlarged costochondral junctions (J:73418)
• severe rib curvature (J:73418)
• enlarged costochondral junctions (J:73418)
• severe rib curvature (J:73418)

endocrine/exocrine glands
• with decreased cortical-medullary demarcation (J:73418)
• with decreased cortical-medullary demarcation (J:73418)





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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory