Analysis Tools
mortality/aging
neoplasm
endocrine/exocrine glands
nervous system
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Allele Symbol Allele Name Allele ID |
Tg(Gfap-cre)2Brn transgene insertion 2, Anton Berns MGI:2663939 |
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| Summary |
10 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• as in Rb1tm2Brn/Rb1tm2Brn Trp53tm1Brn/Trp53tm1Brn Tg(Gfap-cre)2Brn mice
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• large cell carcinoma
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• as in Rb1tm2Brn/Rb1tm2Brn Trp53tm1Brn/Trp53tm1Brn Tg(Gfap-cre)2Brn mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Pituitary tumor in Gt(ROSA)26Sortm1(CAG-Bmi1,-EGFP)Nki/Gt(ROSA)26Sor+ Tg(Gfap-cre)2Brn/0 mice
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• pituitary tumors, mammary gland tumors and primitive neuroectodermal tumors
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• 8 of 16 solid tumors with a latency of a year
• intermediate and anterior lobe
• positive for adrenocorticotropic hormone
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• 8 of 16 solid tumors with a latency of a year
• intermediate and anterior lobe
• positive for adrenocorticotropic hormone
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• 8 of 16 solid tumors with a latency of a year
• intermediate and anterior lobe
• positive for adrenocorticotropic hormone
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• large cell carcinoma
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• choroid plexus papilloma
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mutants develop highly aggressive embryonal tumors of the cerebellum with typical features of medulloblastoma
• tumors are identified as early as 7 weeks of age on the outer surface of the molecular layer, corresponding to the location of the cerebellar external granular layer cells during development
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• loss of balance
• mutants hold their heads to one side
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• gait is disturbed with ataxia
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• mutants develop highly aggressive embryonal tumors of the cerebellum with typical features of medulloblastoma
• tumors are identified as early as 7 weeks of age on the outer surface of the molecular layer, corresponding to the location of the cerebellar external granular layer cells during development
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| medulloblastoma | DOID:0050902 |
OMIM:155255 |
J:61961 | |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• ovariectomized mice fail to exhibit a change in body temperature unlike similarly treated wild-type mice
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• in female mice during the light phase
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• mice injected with RANKL (Tnfsf11) or LPS fail to develop severe hyperthermia unlike similarly treated wild-type mice
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• mice injected with RANKL (Tnfsf11) fail to exhibit an increase in prostagladin levels unlike similarly treated wild-type mice
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• mice injected with RANKL (Tnfsf11) fail to develop severe hyperthermia and do not exhibit a change in diurnal activity unlike similarly treated wild-type mice
• mice injected with Il1b or TNF exhibit an impaired fever response and alterations in circadian activity compared with similarly treated wild-type mice
• mice injected with RANKL (Tnfsf11) fail to exhibit an increase in prostagladin levels unlike similarly treated wild-type mice
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• mice injected with LPS fail to develop severe hyperthermia and do not exhibit a change in diurnal activity unlike similarly treated wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• large cell carcinoma
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mutants develop medulloblastomas
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• mutants develop medulloblastomas
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| medulloblastoma | DOID:0050902 |
OMIM:155255 |
J:61961 | |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mutants are healthy and fertile and do not develop medulloblastomas and glial malignancies
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• hypotonic phenotype leads to premature death
• frequency of deaths peaks at around 3 days of age
• 20% of mice have a normal life span
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• 80% of homozygotes show a strong hypotonic phenotype
• onset from day 1 through 10 days of age
• 20% of mice develop no phenotype
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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