Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2dlAb1-Ea mutation
(13 available);
any
H2 mutation
(280 available)
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mortality/aging
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• following infection with either a low or high dose of IOE, mice succumb to the infection at 11 to 15 days and 7 to 9 days, respectively, compared to wild-type mice, which succumb at 14 to 17 days and 8 to 12 days, respectively
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immune system
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• mice are more susceptible to infection with a monocytotropic Ehrlichia bacteria from Ixodes ovatrus ticks (IOE) than wild-type mice
• following infection with either a low or high dose of IOE, mice succumb to the infection at 11 to 15 days and 7 to 9 days, respectively, compared to wild-type mice, which succumb at 14 to 17 days and 8 to 12 days, respectively
• mice have higher burdens of Ehrlichia bacteria in all organs following infection than do wild-type mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2dlAb1-Ea mutation
(13 available);
any
H2 mutation
(280 available)
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immune system
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N |
• stimulated dendritic cells produce normal amounts of IL-12 and TNF-alpha
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• significantly decreased number of CD4+ thymocytes
• almost completely absent in spleen and lymph nodes
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hematopoietic system
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• significantly decreased number of CD4+ thymocytes
• almost completely absent in spleen and lymph nodes
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immune system
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N |
• stimulated dendritic cells produce normal amounts of IL-12 and TNF-alpha
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2dlAb1-Ea mutation
(13 available);
any
H2 mutation
(280 available)
Rag1tm1Mom mutation
(49 available);
any
Rag1 mutation
(120 available)
Tg(HLA-DRA,HLA-DRB5*0101)hiKito mutation
(0 available)
Tg(TRATL3A6,TRBTL3A6)#Kito mutation
(0 available)
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immune system
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• mice develop spontaneous autoimmune encephalitis with an incidence of 58.3; onset of disease is around 6 weeks of age
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nervous system
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• mice develop spontaneous autoimmune encephalitis with an incidence of 58.3; onset of disease is around 6 weeks of age
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2dlAb1-Ea mutation
(13 available);
any
H2 mutation
(280 available)
Rag1tm1Mom mutation
(49 available);
any
Rag1 mutation
(120 available)
Tg(HLA-DRA,HLA-DRB5*0101)loKito mutation
(0 available)
Tg(TRATL3A6,TRBTL3A6)#Kito mutation
(0 available)
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immune system
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• mice develop spontaneous experimental autoimmune encephalitis with an incidence of 5%; onset of disease is around 12 weeks of age
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nervous system
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• mice develop spontaneous experimental autoimmune encephalitis with an incidence of 5%; onset of disease is around 12 weeks of age
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2dlAb1-Ea mutation
(13 available);
any
H2 mutation
(280 available)
Rr381em2Kap mutation
(0 available);
any
Rr381 mutation
(0 available)
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hematopoietic system
immune system
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2dlAb1-Ea mutation
(13 available);
any
H2 mutation
(280 available)
Rr381em4Kap mutation
(0 available);
any
Rr381 mutation
(0 available)
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hematopoietic system
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• almost complete redirection of MHC class I-specific T cells to CD4+ lineage
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immune system
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• almost complete redirection of MHC class I-specific T cells to CD4+ lineage
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2dlAb1-Ea mutation
(13 available);
any
H2 mutation
(280 available)
Rr381em5Kap mutation
(0 available);
any
Rr381 mutation
(0 available)
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hematopoietic system
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• almost complete redirection of MHC class I-specific T cells to CD4+ lineage
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immune system
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• almost complete redirection of MHC class I-specific T cells to CD4+ lineage
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2dlAb1-Ea mutation
(13 available);
any
H2 mutation
(280 available)
Psmb11tm1(Psmb8)Khog mutation
(0 available);
any
Psmb11 mutation
(10 available)
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immune system
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• perturbed selection at the double positive or cortical stage of CD8 T cell development
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• immature and mater thymocytes
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hematopoietic system
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• perturbed selection at the double positive or cortical stage of CD8 T cell development
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• immature and mater thymocytes
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2dlAb1-Ea mutation
(13 available);
any
H2 mutation
(280 available)
Tg(HLA-DRA,HLA-DRB5*0101)hiKito mutation
(0 available)
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nervous system
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N |
• mice do not develop experimental autoimmune encephalitis following induction with MBP (83-99)
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2dlAb1-Ea mutation
(13 available);
any
H2 mutation
(280 available)
Tg(TRATL3A6,TRBTL3A6)#Kito mutation
(0 available)
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nervous system
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N |
• mice do not develop experimental autoimmune encephalitis following induction with MBP (83-99)
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2dlAb1-Ea mutation
(13 available);
any
H2 mutation
(280 available)
Tg(HLA-DRA,HLA-DRB5*0101)loKito mutation
(0 available)
Tg(TRATL3A6,TRBTL3A6)#Kito mutation
(0 available)
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immune system
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• mice rarely exhibit experimental autoimmune encephalitis when immunized with CFA or pertussis alone, but immunization with MBP (83-99) in CFA with pertussis elicits encephalitis in 47% of mice
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• mice develop spontaneous autoimmune encephalitis with an incidence of <1%; onset of disease is around 21 weeks of age
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nervous system
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• mice develop spontaneous autoimmune encephalitis with an incidence of <1%; onset of disease is around 21 weeks of age
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2dlAb1-Ea mutation
(13 available);
any
H2 mutation
(280 available)
Tg(HLA-DRA,HLA-DRB5*0101)hiKito mutation
(0 available)
Tg(TRATL3A6,TRBTL3A6)#Kito mutation
(0 available)
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immune system
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• mice show greater numbers of Th1-, Th17-, and GM-CSF+-expressing CD4 T cells in response to MBP (83-99)
• mice that spontaneously develop EAE have greater numbers of MBP-specific Th1, and GM-CDF+ CD4+ T cells in the CNS during the course of spontaneous EAE
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• in both induced and spontaneous EAE mice
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• in both induced and spontaneous EAE mice
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• mice show an increased production of IFN-gamma, IL-17, and GM-CSF cytokines in response to MBP (83-99)
• mice that spontaneously develop EAE exhibit an increased production of IFN-gamma, IL-7 and GM-CSF cytokines in the CNS
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• in both induced and spontaneous EAE mice
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• in both induced and spontaneous EAE mice
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• mice rarely exhibit experimental autoimmune encephalitis (EAE) when immunized with CFA or pertussis alone, but immunization with MBP (83-99) in CFA with pertussis elicits encephalitis in 90% of mice
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• mice that develop either induced or spontaneous EAE show mild redicultis of the spinal nerve root and mild neuritis of the cranial nerve root in less than 50% of sections examined
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• mice that develop either induced or spontaneous EAE show severe/moderate inflammation in the spinal cord (meningomyelitis), with lesser involvement of the brainstem and infiltrates contain predominantly CD4+ T cells and mononuclear cells, as well as polymorphnuclear leukocytes/granulocytes
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• mice develop spontaneous experimental autoimmune encephalitis (EAE) with an incidence of 4.5%; onset of disease is around 10 weeks of age
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behavior/neurological
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• both induced and spontaneous EAE mice develop ascending motor deficits
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hematopoietic system
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• mice show greater numbers of Th1-, Th17-, and GM-CSF+-expressing CD4 T cells in response to MBP (83-99)
• mice that spontaneously develop EAE have greater numbers of MBP-specific Th1, and GM-CDF+ CD4+ T cells in the CNS during the course of spontaneous EAE
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• in both induced and spontaneous EAE mice
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• in both induced and spontaneous EAE mice
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nervous system
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• mice that develop either induced or spontaneous EAE show severe/moderate inflammation in the spinal cord (meningomyelitis), with lesser involvement of the brainstem and infiltrates contain predominantly CD4+ T cells and mononuclear cells, as well as polymorphnuclear leukocytes/granulocytes
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• mice develop spontaneous experimental autoimmune encephalitis (EAE) with an incidence of 4.5%; onset of disease is around 10 weeks of age
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• both induced and spontaneous EAE mice exhibit swollen axons throughout the spinal cord
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• both induced and spontaneous EAE mice exhibit degenerating neurons throughout the spinal cord
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• both induced and spontaneous EAE mice exhibit loss of axons
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Analysis Tools