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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
H2dlAb1-Ea
targeted deletion, H2 complex
MGI:2658725
Summary 10 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
H2dlAb1-Ea/H2dlAb1-Ea B6.129S2-H2dlAb1-Ea/J MGI:3580480
hm2
H2dlAb1-Ea/H2dlAb1-Ea involves: 129S2/SvPas * C57BL/6 MGI:4436873
cx3
H2dlAb1-Ea/H2dlAb1-Ea
Marchf1tm1.1Sish/Marchf1tm1.1Sish
involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6 MGI:4436870
cx4
H2dlAb1-Ea/H2dlAb1-Ea
Rag1tm1Mom/Rag1tm1Mom
Tg(HLA-DRA,HLA-DRB5*0101)loKito/0
Tg(TRATL3A6,TRBTL3A6)#Kito/0
involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6 MGI:5635503
cx5
H2dlAb1-Ea/H2dlAb1-Ea
Rag1tm1Mom/Rag1tm1Mom
Tg(HLA-DRA,HLA-DRB5*0101)hiKito/0
Tg(TRATL3A6,TRBTL3A6)#Kito/0
involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6 MGI:5635499
cx6
H2dlAb1-Ea/H2dlAb1-Ea
Tg(TRATL3A6,TRBTL3A6)#Kito/0
involves: 129S2/SvPas * C57BL/6 MGI:5635486
cx7
H2dlAb1-Ea/H2dlAb1-Ea
Tg(HLA-DRA,HLA-DRB5*0101)loKito/0
Tg(TRATL3A6,TRBTL3A6)#Kito/0
involves: 129S2/SvPas * C57BL/6 MGI:5635488
cx8
H2dlAb1-Ea/H2dlAb1-Ea
Tg(HLA-DRA,HLA-DRB5*0101)hiKito/0
Tg(TRATL3A6,TRBTL3A6)#Kito/0
involves: 129S2/SvPas * C57BL/6 MGI:5635492
cx9
H2dlAb1-Ea/H2dlAb1-Ea
Psmb11tm1(Psmb8)Khog/Psmb11tm1(Psmb8)Khog
involves: 129S2/SvPas * C57BL/6 MGI:5514414
cx10
H2dlAb1-Ea/H2dlAb1-Ea
Tg(HLA-DRA,HLA-DRB5*0101)hiKito/0
involves: 129S2/SvPas * C57BL/6 MGI:5635484


Genotype
MGI:3580480
hm1
Allelic
Composition
H2dlAb1-Ea/H2dlAb1-Ea
Genetic
Background
B6.129S2-H2dlAb1-Ea/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2dlAb1-Ea mutation (12 available); any H2 mutation (264 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• following infection with either a low or high dose of IOE, mice succumb to the infection at 11 to 15 days and 7 to 9 days, respectively, compared to wild-type mice, which succumb at 14 to 17 days and 8 to 12 days, respectively

immune system
• mice are more susceptible to infection with a monocytotropic Ehrlichia bacteria from Ixodes ovatrus ticks (IOE) than wild-type mice
• following infection with either a low or high dose of IOE, mice succumb to the infection at 11 to 15 days and 7 to 9 days, respectively, compared to wild-type mice, which succumb at 14 to 17 days and 8 to 12 days, respectively
• mice have higher burdens of Ehrlichia bacteria in all organs following infection than do wild-type mice




Genotype
MGI:4436873
hm2
Allelic
Composition
H2dlAb1-Ea/H2dlAb1-Ea
Genetic
Background
involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2dlAb1-Ea mutation (12 available); any H2 mutation (264 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• stimulated dendritic cells produce normal amounts of IL-12 and TNF-alpha
• significantly decreased number of CD4+ thymocytes
• almost completely absent in spleen and lymph nodes

hematopoietic system
• significantly decreased number of CD4+ thymocytes
• almost completely absent in spleen and lymph nodes




Genotype
MGI:4436870
cx3
Allelic
Composition
H2dlAb1-Ea/H2dlAb1-Ea
Marchf1tm1.1Sish/Marchf1tm1.1Sish
Genetic
Background
involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2dlAb1-Ea mutation (12 available); any H2 mutation (264 available)
Marchf1tm1.1Sish mutation (0 available); any Marchf1 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• stimulated dendritic cells produce normal amounts of IL-12 and TNF-alpha




Genotype
MGI:5635503
cx4
Allelic
Composition
H2dlAb1-Ea/H2dlAb1-Ea
Rag1tm1Mom/Rag1tm1Mom
Tg(HLA-DRA,HLA-DRB5*0101)loKito/0
Tg(TRATL3A6,TRBTL3A6)#Kito/0
Genetic
Background
involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2dlAb1-Ea mutation (12 available); any H2 mutation (264 available)
Rag1tm1Mom mutation (44 available); any Rag1 mutation (80 available)
Tg(HLA-DRA,HLA-DRB5*0101)loKito mutation (0 available)
Tg(TRATL3A6,TRBTL3A6)#Kito mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• mice develop spontaneous experimental autoimmune encephalitis with an incidence of 5%; onset of disease is around 12 weeks of age

nervous system
• mice develop spontaneous experimental autoimmune encephalitis with an incidence of 5%; onset of disease is around 12 weeks of age




Genotype
MGI:5635499
cx5
Allelic
Composition
H2dlAb1-Ea/H2dlAb1-Ea
Rag1tm1Mom/Rag1tm1Mom
Tg(HLA-DRA,HLA-DRB5*0101)hiKito/0
Tg(TRATL3A6,TRBTL3A6)#Kito/0
Genetic
Background
involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2dlAb1-Ea mutation (12 available); any H2 mutation (264 available)
Rag1tm1Mom mutation (44 available); any Rag1 mutation (80 available)
Tg(HLA-DRA,HLA-DRB5*0101)hiKito mutation (0 available)
Tg(TRATL3A6,TRBTL3A6)#Kito mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• mice develop spontaneous autoimmune encephalitis with an incidence of 58.3; onset of disease is around 6 weeks of age

nervous system
• mice develop spontaneous autoimmune encephalitis with an incidence of 58.3; onset of disease is around 6 weeks of age




Genotype
MGI:5635486
cx6
Allelic
Composition
H2dlAb1-Ea/H2dlAb1-Ea
Tg(TRATL3A6,TRBTL3A6)#Kito/0
Genetic
Background
involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2dlAb1-Ea mutation (12 available); any H2 mutation (264 available)
Tg(TRATL3A6,TRBTL3A6)#Kito mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• mice do not develop experimental autoimmune encephalitis following induction with MBP (83-99)




Genotype
MGI:5635488
cx7
Allelic
Composition
H2dlAb1-Ea/H2dlAb1-Ea
Tg(HLA-DRA,HLA-DRB5*0101)loKito/0
Tg(TRATL3A6,TRBTL3A6)#Kito/0
Genetic
Background
involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2dlAb1-Ea mutation (12 available); any H2 mutation (264 available)
Tg(HLA-DRA,HLA-DRB5*0101)loKito mutation (0 available)
Tg(TRATL3A6,TRBTL3A6)#Kito mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• mice rarely exhibit experimental autoimmune encephalitis when immunized with CFA or pertussis alone, but immunization with MBP (83-99) in CFA with pertussis elicits encephalitis in 47% of mice
• mice develop spontaneous autoimmune encephalitis with an incidence of <1%; onset of disease is around 21 weeks of age

nervous system
• mice develop spontaneous autoimmune encephalitis with an incidence of <1%; onset of disease is around 21 weeks of age




Genotype
MGI:5635492
cx8
Allelic
Composition
H2dlAb1-Ea/H2dlAb1-Ea
Tg(HLA-DRA,HLA-DRB5*0101)hiKito/0
Tg(TRATL3A6,TRBTL3A6)#Kito/0
Genetic
Background
involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2dlAb1-Ea mutation (12 available); any H2 mutation (264 available)
Tg(HLA-DRA,HLA-DRB5*0101)hiKito mutation (0 available)
Tg(TRATL3A6,TRBTL3A6)#Kito mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• mice show greater numbers of Th1-, Th17-, and GM-CSF+-expressing CD4 T cells in response to MBP (83-99)
• mice that spontaneously develop EAE have greater numbers of MBP-specific Th1, and GM-CDF+ CD4+ T cells in the CNS during the course of spontaneous EAE
• in both induced and spontaneous EAE mice
• in both induced and spontaneous EAE mice
• mice show an increased production of IFN-gamma, IL-17, and GM-CSF cytokines in response to MBP (83-99)
• mice that spontaneously develop EAE exhibit an increased production of IFN-gamma, IL-7 and GM-CSF cytokines in the CNS
• in both induced and spontaneous EAE mice
• in both induced and spontaneous EAE mice
• mice rarely exhibit experimental autoimmune encephalitis (EAE) when immunized with CFA or pertussis alone, but immunization with MBP (83-99) in CFA with pertussis elicits encephalitis in 90% of mice
• mice that develop either induced or spontaneous EAE show mild redicultis of the spinal nerve root and mild neuritis of the cranial nerve root in less than 50% of sections examined
• mice that develop either induced or spontaneous EAE show severe/moderate inflammation in the spinal cord (meningomyelitis), with lesser involvement of the brainstem and infiltrates contain predominantly CD4+ T cells and mononuclear cells, as well as polymorphnuclear leukocytes/granulocytes
• mice develop spontaneous experimental autoimmune encephalitis (EAE) with an incidence of 4.5%; onset of disease is around 10 weeks of age

behavior/neurological
• both induced and spontaneous EAE mice develop ascending motor deficits

hematopoietic system
• mice show greater numbers of Th1-, Th17-, and GM-CSF+-expressing CD4 T cells in response to MBP (83-99)
• mice that spontaneously develop EAE have greater numbers of MBP-specific Th1, and GM-CDF+ CD4+ T cells in the CNS during the course of spontaneous EAE
• in both induced and spontaneous EAE mice
• in both induced and spontaneous EAE mice

nervous system
• mice that develop either induced or spontaneous EAE show severe/moderate inflammation in the spinal cord (meningomyelitis), with lesser involvement of the brainstem and infiltrates contain predominantly CD4+ T cells and mononuclear cells, as well as polymorphnuclear leukocytes/granulocytes
• mice develop spontaneous experimental autoimmune encephalitis (EAE) with an incidence of 4.5%; onset of disease is around 10 weeks of age
• both induced and spontaneous EAE mice exhibit swollen axons throughout the spinal cord
• both induced and spontaneous EAE mice exhibit degenerating neurons throughout the spinal cord
• both induced and spontaneous EAE mice exhibit loss of axons

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
multiple sclerosis DOID:2377 OMIM:126200
OMIM:612594
OMIM:612595
OMIM:612596
OMIM:614810
J:189816




Genotype
MGI:5514414
cx9
Allelic
Composition
H2dlAb1-Ea/H2dlAb1-Ea
Psmb11tm1(Psmb8)Khog/Psmb11tm1(Psmb8)Khog
Genetic
Background
involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2dlAb1-Ea mutation (12 available); any H2 mutation (264 available)
Psmb11tm1(Psmb8)Khog mutation (0 available); any Psmb11 mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• perturbed selection at the double positive or cortical stage of CD8 T cell development
• immature and mater thymocytes

hematopoietic system
• perturbed selection at the double positive or cortical stage of CD8 T cell development
• immature and mater thymocytes




Genotype
MGI:5635484
cx10
Allelic
Composition
H2dlAb1-Ea/H2dlAb1-Ea
Tg(HLA-DRA,HLA-DRB5*0101)hiKito/0
Genetic
Background
involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2dlAb1-Ea mutation (12 available); any H2 mutation (264 available)
Tg(HLA-DRA,HLA-DRB5*0101)hiKito mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• mice do not develop experimental autoimmune encephalitis following induction with MBP (83-99)





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/05/2019
MGI 6.14
The Jackson Laboratory