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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Leprtm1Mgmj
targeted mutation 1, Martin G Myers, Jr
MGI:2653294
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Leprtm1Mgmj/Leprtm1Mgmj B6.129-Leprtm1Mgmj MGI:2653295
hm2
Leprtm1Mgmj/Leprtm1Mgmj involves: 129/Sv MGI:4843199
ht3
Leprtm1Mgmj/Lepr+ B6.129-Leprtm1Mgmj MGI:3697522


Genotype
MGI:2653295
hm1
Allelic
Composition
Leprtm1Mgmj/Leprtm1Mgmj
Genetic
Background
B6.129-Leprtm1Mgmj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Leprtm1Mgmj mutation (1 available); any Lepr mutation (65 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• body weight is 2- to 3-fold more than in wild-type mice by 10 weeks of age
• however, body weight is 10% and 20% less in males and females, respectively, compared to Leprrdb homozygotes
• snout to anus length is increased by about 5% compared to wild-type mice

behavior/neurological

homeostasis/metabolism
• increased neointimal hyperplasia relative to Leprdb 4 weeks after femoral artery injury
• mice pair-fed with wild-type mice gain more weight and adipose tissue than wild-type mice
• increase in glucose is less than in Leprrdb homozygotes

reproductive system
• slight delay in the onset of oestrous cycling, median onset at 42 days rather than 36 days as in wild-type mice
• however, all females show signs of vaginal oestrous and no defects in ovulation are seen
• only about 40% of females are fertile

endocrine/exocrine glands
• pups born to homozygous females die within 24 h without milk in their stomachs unless fostered to wild-type mothers

cardiovascular system
• increased neointimal hyperplasia relative to Leprdb 4 weeks after femoral artery injury

integument
• pups born to homozygous females die within 24 h without milk in their stomachs unless fostered to wild-type mothers

Mouse Models of Human Disease
OMIM ID Ref(s)
Obesity 601665 J:82334




Genotype
MGI:4843199
hm2
Allelic
Composition
Leprtm1Mgmj/Leprtm1Mgmj
Genetic
Background
involves: 129/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Leprtm1Mgmj mutation (1 available); any Lepr mutation (65 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• in 5 of 8 mice
• 3 of 8 mice




Genotype
MGI:3697522
ht3
Allelic
Composition
Leprtm1Mgmj/Lepr+
Genetic
Background
B6.129-Leprtm1Mgmj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Leprtm1Mgmj mutation (1 available); any Lepr mutation (65 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• slight but significant increase in body weight compared to wild-type mice





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory