growth/size
|
• snout to anus length is increased by about 5% compared to wild-type mice
|
|
• body weight is 2- to 3-fold more than in wild-type mice by 10 weeks of age
• however, body weight is 10% and 20% less in males and females, respectively, compared to Leprrdb homozygotes
|
behavior/neurological
polyphagia
(
J:82334
)
homeostasis/metabolism
|
• increased neointimal hyperplasia relative to Leprdb 4 weeks after femoral artery injury
|
|
• mice pair-fed with wild-type mice gain more weight and adipose tissue than wild-type mice
|
|
• increase in glucose is less than in Leprrdb homozygotes
|
reproductive system
 |
• slight delay in the onset of oestrous cycling, median onset at 42 days rather than 36 days as in wild-type mice
(J:82334)
• however, all females show signs of vaginal oestrous and no defects in ovulation are seen
(J:82334)
|
|
|
• only about 40% of females are fertile
(J:82334)
|
endocrine/exocrine glands
|
|
• pups born to homozygous females die within 24 h without milk in their stomachs unless fostered to wild-type mothers
(J:82334)
|
cardiovascular system
|
• increased neointimal hyperplasia relative to Leprdb 4 weeks after femoral artery injury
|
|
• similar to to Leprdb
|
integument
|
|
• pups born to homozygous females die within 24 h without milk in their stomachs unless fostered to wild-type mothers
(J:82334)
|