Mouse Genome Informatics
hm1
    Leprtm1Mgmj/Leprtm1Mgmj
B6.129-Leprtm1Mgmj
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
growth/size
• body weight is 2- to 3-fold more than in wild-type mice by 10 weeks of age
• however, body weight is 10% and 20% less in males and females, respectively, compared to Leprrdb homozygotes
• snout to anus length is increased by about 5% compared to wild-type mice

behavior/neurological

homeostasis/metabolism
• increased neointimal hyperplasia relative to Leprdb 4 weeks after femoral artery injury
• mice pair-fed with wild-type mice gain more weight and adipose tissue than wild-type mice
• increase in glucose is less than in Leprrdb homozygotes

reproductive system
• slight delay in the onset of oestrous cycling, median onset at 42 days rather than 36 days as in wild-type mice (J:82334)
• however, all females show signs of vaginal oestrous and no defects in ovulation are seen (J:82334)
• only about 40% of females are fertile (J:82334)

endocrine/exocrine glands
• pups born to homozygous females die within 24 h without milk in their stomachs unless fostered to wild-type mothers (J:82334)

cardiovascular system
• increased neointimal hyperplasia relative to Leprdb 4 weeks after femoral artery injury

integument
• pups born to homozygous females die within 24 h without milk in their stomachs unless fostered to wild-type mothers (J:82334)

Mouse Models of Human Disease
OMIM IDRef(s)
Obesity 601665 J:82334


Mouse Genome Informatics
hm2
    Leprtm1Mgmj/Leprtm1Mgmj
involves: 129/Sv
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
reproductive system
• in 5 of 8 mice (J:164339)
• 3 of 8 mice (J:164339)


Mouse Genome Informatics
ht3
    Leprtm1Mgmj/Lepr+
B6.129-Leprtm1Mgmj
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
growth/size
• slight but significant increase in body weight compared to wild-type mice