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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fevtm1Esd
targeted mutation 1, Evan S Deneris
MGI:2449922
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Fevtm1Esd/Fevtm1Esd involves: 129S1/Sv * 129X1/SvJ MGI:4837212
hm2
 		Fevtm1Esd/Fevtm1Esd involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3663922
ht3
 		Fevtm1Esd/Fevtm2.1Esd involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:4837210
cn4
 		Fevtm1Esd/Fevtm2Esd
Tg(Fev-cre/ERT2)aEsd/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:4837216
cn5
 		Fevtm1Esd/Fevtm2Esd
Tg(Fev-cre)1Esd/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL MGI:4837211
cn6
 		Fevtm1Esd/Fevtm2Esd
Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Tg(Fev-cre)1Esd/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL MGI:4837213


Genotype
MGI:4837212
hm1
Allelic
Composition		 Fevtm1Esd/Fevtm1Esd
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fevtm1Esd mutation (0 available); any Fev mutation (14 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
decreased neuron number ( J:165266 )
• decrease in the number of serotonergic neurons at E11.5
abnormal serotonergic neuron morphology ( J:165266 )
• decreased number at E11.5




Genotype
MGI:3663922
hm2
Allelic
Composition		 Fevtm1Esd/Fevtm1Esd
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fevtm1Esd mutation (0 available); any Fev mutation (14 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
perinatal lethality, incomplete penetrance ( J:81450 )
• small number of deaths within the first week of life

nervous system
abnormal neuron differentiation ( J:81450 )
• serotonin neuron development disrupted in the hindbrain
• precursors formed but most fail to differentiate
• 70% loss of serotinin immunoreactive cell bodies in adult brains
• greatly diminished density of serotonin immunoreactive neurons in the cortex and hippocampus
• B nuclei of the hind brain are missing

behavior/neurological
increased aggression towards mice ( J:81450 )
• shorter latency to attack
increased anxiety-related response ( J:81450 )
• although locomotor activity is normal, mice spend less than normal time in the central areas during an open field test
• never enter the open arms in a plus maze test
impaired coordination ( J:81450 )
• initial rotarod performance poor in comparison to controls
• later performance becomes comparable to controls

cellular
abnormal neuron differentiation ( J:81450 )
• serotonin neuron development disrupted in the hindbrain
• precursors formed but most fail to differentiate
• 70% loss of serotinin immunoreactive cell bodies in adult brains
• greatly diminished density of serotonin immunoreactive neurons in the cortex and hippocampus
• B nuclei of the hind brain are missing




Genotype
MGI:4837210
ht3
Allelic
Composition		 Fevtm1Esd/Fevtm2.1Esd
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fevtm1Esd mutation (0 available); any Fev mutation (14 available)
Fevtm2.1Esd mutation (0 available); any Fev mutation (14 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
decreased neuron number ( J:165266 )
• decrease in the number of tryptophan hydroxylase positive neurons
abnormal serotonergic neuron morphology ( J:165266 )
• decrease in the number of tryptophan hydroxylase positive neurons




Genotype
MGI:4837216
cn4
Allelic
Composition		 Fevtm1Esd/Fevtm2Esd
Tg(Fev-cre/ERT2)aEsd/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fevtm1Esd mutation (0 available); any Fev mutation (14 available)
Fevtm2Esd mutation (0 available); any Fev mutation (14 available)
Tg(Fev-cre/ERT2)aEsd mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
increased anxiety-related response ( J:165266 )
• following 4 weeks of tamoxifen treatment started at 6-8 weeks of age, mice spend less time and make fewer entrances into the open arms of an elevated plus maze
• however, the level of exploratory behavior in the elevated plus maze is normal
• following 4 weeks of tamoxifen treatment started at 6-8 weeks of age, mice spend more time in the dark chamber in a light dark exploration assay
increased thigmotaxis ( J:165266 )
• following 4 weeks of tamoxifen treatment started at 6-8 weeks of age, mice spend less time in the center of an open field

homeostasis/metabolism
decreased serotonin level ( J:165266 )
• following 4 weeks of tamoxifen treatment started at 6-8 weeks of age, brain levels of 5-HT and 5-HIAA are significantly decreased




Genotype
MGI:4837211
cn5
Allelic
Composition		 Fevtm1Esd/Fevtm2Esd
Tg(Fev-cre)1Esd/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fevtm1Esd mutation (0 available); any Fev mutation (14 available)
Fevtm2Esd mutation (0 available); any Fev mutation (14 available)
Tg(Fev-cre)1Esd mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:165266 )
N
• unlike germline null mice, the number of serotonergic neurons is normal at E11.5 and E12.5




Genotype
MGI:4837213
cn6
Allelic
Composition		 Fevtm1Esd/Fevtm2Esd
Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Tg(Fev-cre)1Esd/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fevtm1Esd mutation (0 available); any Fev mutation (14 available)
Fevtm2Esd mutation (0 available); any Fev mutation (14 available)
Gt(ROSA)26Sortm1(EYFP)Cos mutation (11 available); any Gt(ROSA)26Sor mutation (942 available)
Tg(Fev-cre)1Esd mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal somatosensory cortex morphology ( J:165266 )
• serotonergic innervation of the somatosensory cortex from dorsal raphe nucleus 5-HT neurons is significantly disrupted
abnormal innervation ( J:165266 )
• serotonergic innervation of the somatosensory cortex from dorsal raphe nucleus 5-HT neurons is significantly disrupted
abnormal serotonergic neuron morphology ( J:165266 )
• serotonergic innervation of the somatosensory cortex from dorsal raphe nucleus 5-HT neurons is significantly disrupted
abnormal nervous system electrophysiology ( J:165266 )
• neither high nor low concentrations of 8-Hydroxy-2-dipropylaminotetralin hydrobromide (8-OH-DPAT) elicit a change in baseline currents in labeled 5HT neurons
abnormal action potential ( J:165266 )
• YFP+ cells show increased spontaneous firing of action potentials




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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory