Tg(Fev-cre/ERT2)aEsd
Transgene Detail

Summary

• Symbol: Tg(Fev-cre/ERT2)aEsd
• Name: transgene insertion a, Evan S Deneris
• MGI ID: MGI:4837204
• Synonyms: ePet::CreER^T2ascend
• Transgene: Tg(Fev-cre/ERT2)aEsd Location: unknown
• Alliance: Tg(Fev-cre/ERT2)aEsd page

Transgene origin

• Strain of Origin: C57BL/6 x 129

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(Fev-cre/ERT2)aEsd expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	Fev

• Mutation details: A 40 kb genomic fragment of Fev enhancer sequence and a beta-globin minimal promoter drive expression a fusion gene of cre and a mutant human estrogen receptor. This transgene also contains beta-globin intron and simian virus 40 polyadenylation sequences. After tamoxifen treatment this line shows recombination in up to 80% of the serotonergic neurons in the dorsal Raphe nucleus (B6, B7) the medial Raphe nucleus (B5, B8) and B9 nucleus. Minimal recombination is seen in the medullary nuclei (B1-B3). (J:165266)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Fev (species not specified) Summary of all recombinase alleles driven by Fev.

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:165266 Liu C, et al., Pet-1 is required across different stages of life to regulate serotonergic function. Nat Neurosci. 2010 Oct;13(10):1190-8
• All: 1 reference(s)