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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Smarcb1tm3Sho
targeted mutation 3, Stuart Orkin
MGI:2447708
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Smarcb1tm1Sho/Smarcb1tm3Sho
Tg(Mx1-cre)1Cgn/?
involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6 * CBA MGI:3819385
cn2
Smarcb1tm1Sho/Smarcb1tm3Sho
Tg(Gata1-cre)1Sho/?
involves: 129S1/Sv * 129S6/SvEvTac * CD-1 MGI:3819386


Genotype
MGI:3819385
cn1
Allelic
Composition
Smarcb1tm1Sho/Smarcb1tm3Sho
Tg(Mx1-cre)1Cgn/?
Genetic
Background
involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smarcb1tm1Sho mutation (0 available); any Smarcb1 mutation (18 available)
Smarcb1tm3Sho mutation (1 available); any Smarcb1 mutation (18 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• sometimes dramatically
• sometimes dramatically

endocrine/exocrine glands
• 20 of 23 mice have CD8+ T cell lymphomas
• tumor cell types suggestive of malignant lymphocytes

muscle
• 3 out of 23 mice with rhabdoid tumors

neoplasm
• mice normal for about 4 weeks after polyI/polyC injection
• begin to develop cancers after 4 weeks
• 100% develop tumors with a median onset of 11 weeks after polyI/polyC injection
• sometimes an increase in circulating tumor cells
• 3 out of 23 mice with rhabdoid tumors
• periportal lymphoma in the liver
• 20 of 23 mice have CD8+ T cell lymphomas
• tumor cell types suggestive of malignant lymphocytes

immune system
• increase in circulating eosinophiles
• effacement of normal architecture
• sometimes dramatically
• effacement of the normal architecture of involved lymph nodes

hematopoietic system
• often a mild and progressive decrease in blood cell counts
• increase in circulating eosinophiles
• effacement of normal architecture
• sometimes dramatically

liver/biliary system
• periportal lymphomas
• sometimes dramatically

cellular
• in liver and spleen 18-24 hours after polyI/polyC injection




Genotype
MGI:3819386
cn2
Allelic
Composition
Smarcb1tm1Sho/Smarcb1tm3Sho
Tg(Gata1-cre)1Sho/?
Genetic
Background
involves: 129S1/Sv * 129S6/SvEvTac * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smarcb1tm1Sho mutation (0 available); any Smarcb1 mutation (18 available)
Smarcb1tm3Sho mutation (1 available); any Smarcb1 mutation (18 available)
Tg(Gata1-cre)1Sho mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/18/2022
MGI 6.17
The Jackson Laboratory