Phenotypes associated with this allele
Allelic
Composition |
Dcxtm1Caw/Dcx+
|
|
Genetic
Background |
involves: 129S6/SvEvTac * 129X1/SvJ |
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dcxtm1Caw mutation
(0 available);
any
Dcx mutation
(18 available)
|
|
|
behavior/neurological
 |
• female mice show impaired ability to associate stimulus (tone) with unconditioned stimulus (shock) in the fear test
|
|
|
• animals demonstrate mild deficits in latency to find hidden platform in Morris water maze test
|
|
|
• female heterozygous mice show deficits in cage-top hang tests
|
Allelic
Composition |
Dcxtm1Caw/Dcx+
|
|
Genetic
Background |
involves: 129S6/SvEvTac * 129X1/SvJ * Black Swiss |
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dcxtm1Caw mutation
(0 available);
any
Dcx mutation
(18 available)
|
|
|
nervous system
|
|
• hippocampal formation is malformed
|
|
|
• pyramidal layer of CA3 is split in some regions
• pyramidal neurons are more loosely arrayed in some animals
• milder dispruptions of the pyramidal layerare seen in CA2 and CA1 regions
|
behavior/neurological
|
|
• female mice showed impaired ability to associate stimulus (tone) with unconditioned stimulus (shock) in a fear test
|
|
|
• female mice show deficits in cage-top hang tests
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dclk1tm1.1Jgg mutation
(0 available);
any
Dclk1 mutation
(53 available)
Dcxtm1Caw mutation
(0 available);
any
Dcx mutation
(18 available)
|
|
|
mortality/aging
|
|
• pups die before weaning, usually soon after birth
|
nervous system
|
|
• corpus callosum is absent
|
|
|
• there is no apparent laminar structure to the cortex
|
|
|
• cortical neuron distribution is altered, showing a broader pattern of distribution
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dclk1tm1.1Jgg mutation
(0 available);
any
Dclk1 mutation
(53 available)
Dcxtm1Caw mutation
(0 available);
any
Dcx mutation
(18 available)
|
|
|
mortality/aging
 |
• pups die before weaning, usually shortly after birth
|
nervous system
|
|
• corpus callosum is absent
|
|
|
• anterior commissure is hypoplastic
|
|
|
• a cortical lamination defect, most notable in the lateral cortex is apparent
• cytoarchitectonics are disrupted; there is dispersion of the cell-rich layer 2/3
|
Allelic
Composition |
Dclk1tm1.1Jgg/Dclk1+
Dcxtm1Caw/Y
|
|
Genetic
Background |
involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6 |
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dclk1tm1.1Jgg mutation
(0 available);
any
Dclk1 mutation
(53 available)
Dcxtm1Caw mutation
(0 available);
any
Dcx mutation
(18 available)
|
|
|
nervous system
|
|
• corpus callosum is hypoplastic
|
|
|
• anterior commissure is severely reduced in thickness
|
|
|
• cortical neuron distribution is altered, with neurons showing a much broader pattern of distribution
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dclk1tm1.1Jgg mutation
(0 available);
any
Dclk1 mutation
(53 available)
Dcxtm1Caw mutation
(0 available);
any
Dcx mutation
(18 available)
|
|
|
nervous system
|
|
• corpus callosum is absent
|
|
|
• anterior commissure is hypoplastic
|
|
|
• cytoarchitectonics are disrupted; there is dispersion of the cell-rich layer 2/3
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dclk1tm1.1Jgg mutation
(0 available);
any
Dclk1 mutation
(53 available)
Dcxtm1Caw mutation
(0 available);
any
Dcx mutation
(18 available)
|
|
|
nervous system
|
|
• corpus callosum is absent
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dclk1tm1Caw mutation
(0 available);
any
Dclk1 mutation
(53 available)
Dcxtm1Caw mutation
(0 available);
any
Dcx mutation
(18 available)
|
|
|
mortality/aging
|
|
• more than 75% of double knockouts die within 2 days of birth
|
nervous system
|
|
• double knockouts exhibit disruption of most or all major axon tracts in the brain; brains of double knockouts display severely disorganized white-matter tracts
|
|
|
• cerebellum of mutants has defective foliation; folia are severely hypoplastic, particularly on the ventral surface of the cerebellum
|
|
|
• there are no fibers crossing the midline of the corpus callosum; most axons end before reaching the midline and do not cross to the other side
• axons appear as multiple single axons with random orientation and without clear fasciculation rather than bundles
|
|
|
• in mutants, corpus callosum is present at rostral levels but does not extend as far caudally as in wild-type mice; anterior portion is greatly reduced in thickness
|
|
|
• hippocampal commissures appear lumpy and disorganized
|
|
|
• aberrant anterior commissure bundles are observed
|
|
|
• in some animals, internal capsule has abnormal morphology
|
|
|
• there is absence of an internal capsule in the striatum
|
|
|
• disruption of many brainstem nuclei is observed
|
|
|
• there is absence of pencil fibers in the striatum
|
|
|
• disruption of many thalamic nuclei is observed
|
|
|
• stratum pyramidale layer in pyramidal cell fields, CA3,CA2and CA1 is disorganized with multiple cell layers separated by irregular streams of white matter
|
|
|
• at P0, there is disruption of lamination of the cerebral cortex in the cingulate gyrus in double knockouts
|
|
|
• brains of double knockouts at P0 display a thin cerebral cortex
|
|
|
• no axons leave the region of the entorhinal cortex
|
|
|
• subcortical white matter appears lumpy and disorganized
|
|
|
• cells appear less tightly packed
|
|
|
• there is markedly abnormal cell layering in the hippocampus
|
|
|
• the cerebellum is small in double knockouts
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dclk1tm1Caw mutation
(0 available);
any
Dclk1 mutation
(53 available)
Dcxtm1Caw mutation
(0 available);
any
Dcx mutation
(18 available)
|
|
|
reproductive system
|
|
• fertility appears to be reduced
|
Allelic
Composition |
Dclk1tm1Caw/Dclk1+
Dcxtm1Caw/Dcx+
|
|
Genetic
Background |
involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J |
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dclk1tm1Caw mutation
(0 available);
any
Dclk1 mutation
(53 available)
Dcxtm1Caw mutation
(0 available);
any
Dcx mutation
(18 available)
|
|
|
reproductive system
|
|
• fertility appears to be reduced
|
Allelic
Composition |
Dclk1tm1Caw/Dclk1+
Dcxtm1Caw/Y
|
|
Genetic
Background |
involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J |
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dclk1tm1Caw mutation
(0 available);
any
Dclk1 mutation
(53 available)
Dcxtm1Caw mutation
(0 available);
any
Dcx mutation
(18 available)
|
|
|
mortality/aging
|
|
• a slightly lower proportion of Dcx-deficient, Dcamkl1-heterozygous males die postnatally than double knockouts
|
nervous system
|
|
• mutants have less severe and less penetrant white matter defects than double knockouts
|
|
|
• lateral ventricles are enlarged in mutants
|
|
|
• some animals have an absent corpus callosum
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dclk2tm1.2Jgg mutation
(1 available);
any
Dclk2 mutation
(134 available)
Dcxtm1Caw mutation
(0 available);
any
Dcx mutation
(18 available)
|
|
|
mortality/aging
|
|
• less than 10% of mice survive to 5 months of age
|
|
|
• about half the die mice before weaning
|
behavior/neurological
|
|
• repetitive epileptiform discharges from the hippocampus consisting of 4-Hz monomorphic spike activity are observed in mice prior to seizures
• at the onset of the convulsive attack, hippocampus activity increases from 400 microV up to 1 mV, and then transitions into spike and wave appearance at 3-Hz frequency
• these spikes in activity transmit to the cortex about half the time leading to tonic-clonic convulsions
|
|
|
• as early as P16, mice have spontaneous seizures often accompanied by behavioral arrest and forelimb myoclonus
• seizures originate in the hippocampus with spikes in activity that half the time transmit to the cortex and cause tonic-clonic seizures
|
nervous system
|
|
• repetitive epileptiform discharges from the hippocampus consisting of 4-Hz monomorphic spike activity are observed in mice prior to seizures
• at the onset of the convulsive attack, hippocampus activity increases from 400 microV up to 1 mV, and then transitions into spike and wave appearance at 3-Hz frequency
• these spikes in activity transmit to the cortex about half the time leading to tonic-clonic convulsions
|
|
|
• as early as P16, mice have spontaneous seizures often accompanied by behavioral arrest and forelimb myoclonus
• seizures originate in the hippocampus with spikes in activity that half the time transmit to the cortex and cause tonic-clonic seizures
|
|
|
• CaBP+ interneurons that interact with pyramidal neurons are improperly laminated within the stratum radiatum-lacunosum moleculare border
|
|
|
• mice have reduced packing density of the dentate granule neuron layer, resulting in an increased thickness
|
|
|
• mossy fibers fail to separate into the infrapyramidal and the suprapyrimidal bundles and, as a result, mossy fibers travel aberrantly within the pyramidal layer
|
|
|
• lamination density of the granule cell layer is increased in these mice
|
|
|
• pyramidal neurons displayed a striking simplification of apical dendritic arbors with decreased branching from both primary and secondary apical dendrites
|
|
|
• about half of the somatostatin neurons are selectively lost in the hippocampus by day 18 after birth
|
|
|
• about 40% of neurons are displaced into the stratum oriens
|
|
|
• the CA3 region is dyslaminated with a small percentage of neurons heterotopically located in the stratum oriens
|
|
|
• the frequency of spontaneous sIPSC among pyramidal neurons is severely reduced by 55% compared to controls
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dclk2tm1.2Jgg mutation
(1 available);
any
Dclk2 mutation
(134 available)
Dcxtm1Caw mutation
(0 available);
any
Dcx mutation
(18 available)
|
|
|
Hippocampal disorganization, increased c-fos, and loss of SOM+ interneurons in Dcxtm1Caw/Y Dclk2tm1.2Jgg/Dclk2tm1.2Jgg mice
mortality/aging
|
|
• less than 10% of mice survive to 5 months of age
|
|
|
• about half the die mice before weaning
|
behavior/neurological
|
|
• repetitive epileptiform discharges from the hippocampus consisting of 4-Hz monomorphic spike activity are observed in mice prior to seizures
• at the onset of the convulsive attack, hippocampus activity increases from 400 microV up to 1 mV, and then transitions into spike and wave appearance at 3-Hz frequency
• these spikes in activity transmit to the cortex about half the time leading to tonic-clonic convulsions
|
|
|
• as early as P16, mice have spontaneous seizures often accompanied by behavioral arrest and forelimb myoclonus
• seizures originate in the hippocampus with spikes in activity that half the time transmit to the cortex and cause tonic-clonic seizures
|
nervous system
|
|
• repetitive epileptiform discharges from the hippocampus consisting of 4-Hz monomorphic spike activity are observed in mice prior to seizures
• at the onset of the convulsive attack, hippocampus activity increases from 400 microV up to 1 mV, and then transitions into spike and wave appearance at 3-Hz frequency
• these spikes in activity transmit to the cortex about half the time leading to tonic-clonic convulsions
|
|
|
• as early as P16, mice have spontaneous seizures often accompanied by behavioral arrest and forelimb myoclonus
• seizures originate in the hippocampus with spikes in activity that half the time transmit to the cortex and cause tonic-clonic seizures
|
|
|
• CaBP+ interneurons that interact with pyramidal neurons are improperly laminated within the stratum radiatum-lacunosum moleculare border
|
|
|
• mice have reduced packing density of the dentate granule neuron layer, resulting in an increased thickness
|
|
|
• mossy fibers fail to separate into the infrapyramidal and the suprapyrimidal bundles and, as a result, mossy fibers travel aberrantly within the pyramidal layer
|
|
|
• lamination density of the granule cell layer is increased in these mice
|
|
|
• pyramidal neurons displayed a striking simplification of apical dendritic arbors with decreased branching from both primary and secondary apical dendrites
|
|
|
• about half of the somatostatin neurons are selectively lost in the hippocampus by day 18 after birth
|
|
|
• about 40% of neurons are displaced into the stratum oriens
|
|
|
• the CA3 region is dyslaminated with a small percentage of neurons heterotopically located in the stratum oriens
|
|
|
• the frequency of spontaneous sIPSC among pyramidal neurons is severely reduced by 55% compared to controls
|
Allelic
Composition |
Dcxtm1Caw/Y
|
|
Genetic
Background |
involves: 129S6/SvEvTac * 129X1/SvJ * Black Swiss |
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dcxtm1Caw mutation
(0 available);
any
Dcx mutation
(18 available)
|
|
|
mortality/aging
|
|
• only a small number of males survive to adulthood
|
|
|
• majority of hemizygous males die within a few days of birth
|
growth/size/body
|
|
• surviving males are runted compared to littermates
|
behavior/neurological
|
|
• hemizygous male mice tested show similar deficits to heterozygous female littermates in behavioral tests
|
nervous system
|
|
• hippocampal formation is malformed
|
|
|
• pyramidal layer of CA3 is split in some regions
• pyramidal neurons are more loosely arrayed in some animals
• there are milder disruptions of the pyramidal layer in CA2 And CA1 regions
|
reproductive system
|
|
• males show variable fertility
|
Allelic
Composition |
Dcxtm1Caw/Y
|
|
Genetic
Background |
involves: 129/Sv * C57BL/6 |
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dcxtm1Caw mutation
(0 available);
any
Dcx mutation
(18 available)
|
|
|
Dyslaminated interneuron populations in Dcxtm1Caw/Y Dclk2tm1.2Jgg/Dclk2tm1.2Jgg and Dcxtm1Caw/Y mice
nervous system
|
|
• the CA3 region is dyslaminated by 11 days of age
|
|
|
• the infrapyramidal mossy fiber bundle crosses the pyramidal layer and merges prematurely with the suprapyrimidal bundle
|
|
|
• the frequency of spontaneous sIPSC among pyramidal neurons is somewhat reduced compared to controls
|
Analysis Tools