All Phenotypes Gna12<tm1Citb> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gna12^tm1Citb
targeted mutation 1, California Institute of Technology - Biology
MGI:2183606

Summary

13 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gna12^tm1Citb/Gna12^tm1Citb	involves: 129S1/Sv * C57BL/6	MGI:3037545
cn2	Gna12^tm1Citb/Gna12^tm1Citb Gna13^tm2Cgh/Gna13^tm2Cgh Grhl3^tm1(cre)Cgh/Grhl3⁺	involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJae * C57BL/6 * SJL	MGI:4438090
cn3	Gna12^tm1Citb/Gna12^tm1Citb Gna13^tm2.1Soff/Gna13^tm2.1Soff Tg(Tek-icre/ERT2)1Soff/?	involves: 129P2/OlaHsd * 129S1/Sv * FVB/N	MGI:3837460
cn4	Cd19^tm1(cre)Cgn/Cd19⁺ Gna12^tm1Citb/Gna12^tm1Citb Gna13^tm2.1Soff/Gna13^tm2.1Soff	involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6N	MGI:3699320
cn5	Gna12^tm1Citb/Gna12^tm1Citb Gna13^tm2.1Soff/Gna13^tm2.1Soff Tg(Lck-cre)548Jxm/0	involves: 129S1/Sv * C57BL/6 * CBA	MGI:3849203
cn6	Gna12^tm1Citb/Gna12^tm1Citb Gna13^tm2.1Soff/Gna13^tm2.1Soff Tg(Mx1-cre)1Cgn/0	involves: 129S1/Sv * C57BL/6 * CBA * FVB/N	MGI:3699352
cn7	Gna12^tm1Citb/Gna12^tm1Citb Gna13^tm2.1Soff/Gna13^tm2.1Soff X/Tg(Myh11-icre/ERT2)1Soff	involves: 129S1/Sv * FVB/N	MGI:3819345
cx8	Gna12^tm1Citb/Gna12^tm1Citb Gna13^tm1Soff/Gna13^tm1Soff	involves: 129S1/Sv * C57BL/6	MGI:3037546
cx9	Gna12^tm1Citb/Gna12^tm1Citb Gna13^tm1Soff/Gna13⁺	involves: 129S1/Sv * C57BL/6	MGI:3037547
cx10	Gna12^tm1Citb/Gna12⁺ Gna13^tm1Soff/Gna13⁺	involves: 129S1/Sv * C57BL/6	MGI:3037548
cx11	Gna12^tm1Citb/Gna12⁺ Gna13^tm1Soff/Gna13^tm1Soff	involves: 129S1/Sv * C57BL/6	MGI:3037549
cx12	Gna12^tm1Citb/Gna12^tm1Citb Gnaq^tm1Soff/Gnaq^tm1Soff	involves: 129S1/Sv * C57BL/6	MGI:3037550
cx13	Gna12^tm1Citb/Gna12⁺ Gnaq^tm1Soff/Gnaq^tm1Soff	involves: 129S1/Sv * C57BL/6	MGI:3037551

Allelic Composition	Gna12^tm1Citb/Gna12^tm1Citb
Genetic Background	involves: 129S1/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gna12^tm1Citb mutation (0 available); any Gna12 mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:77728 )

• mice are viable and fertile; no gross morphological or behavioral abnormalities

Allelic Composition	Gna12^tm1Citb/Gna12^tm1Citb Gna13^tm2Cgh/Gna13^tm2Cgh Grhl3^tm1(cre)Cgh/Grhl3⁺
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJae * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gna12^tm1Citb mutation (0 available); any Gna12 mutation (21 available)
Gna13^tm2Cgh mutation (0 available); any Gna13 mutation (12 available)
Grhl3^tm1(cre)Cgh mutation (1 available); any Grhl3 mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:157446 )

• mutants die by 10.5 days post coitus (dpc)

embryo

abnormal embryo development ( J:157446 )

• embryos display turning defects and other defects, but the hindbrain neuropore is closed in mutants at 10.5 dpc

abnormal embryo turning ( J:157446 )

• embryos show turning defects

Allelic Composition	Gna12^tm1Citb/Gna12^tm1Citb Gna13^tm2.1Soff/Gna13^tm2.1Soff Tg(Tek-icre/ERT2)1Soff/?
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gna12^tm1Citb mutation (0 available); any Gna12 mutation (21 available)
Gna13^tm2.1Soff mutation (0 available); any Gna13 mutation (12 available)
Tg(Tek-icre/ERT2)1Soff mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:146132 )

N	• tamoxifen-treated mice respond similar to wild-type controls in experiments testing response to anaphylactic shock

Allelic Composition	Cd19^tm1(cre)Cgn/Cd19⁺ Gna12^tm1Citb/Gna12^tm1Citb Gna13^tm2.1Soff/Gna13^tm2.1Soff
Genetic Background	involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19^tm1(cre)Cgn mutation (11 available); any Cd19 mutation (56 available)
Gna12^tm1Citb mutation (0 available); any Gna12 mutation (21 available)
Gna13^tm2.1Soff mutation (0 available); any Gna13 mutation (12 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased marginal zone B cell number ( J:117663 )

• marginal zone B cell numbers are strongly reduced compared to controls

abnormal B cell physiology ( J:117663 )

• lysophospholipid-induced induced adhesion is completely abrogated in marginal zone mutant B cells and is reduced in follicular B cells

• lysophospholipid-induced induced LFA-1 (integrin) clustering is abolished in mutant B cells

immune system

decreased marginal zone B cell number ( J:117663 )

• marginal zone B cell numbers are strongly reduced compared to controls

abnormal B cell physiology ( J:117663 )

• lysophospholipid-induced induced adhesion is completely abrogated in marginal zone mutant B cells and is reduced in follicular B cells

• lysophospholipid-induced induced LFA-1 (integrin) clustering is abolished in mutant B cells

Allelic Composition	Gna12^tm1Citb/Gna12^tm1Citb Gna13^tm2.1Soff/Gna13^tm2.1Soff Tg(Lck-cre)548Jxm/0
Genetic Background	involves: 129S1/Sv * C57BL/6 * CBA

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased T cell proliferation ( J:149560 )

• homeostatic CD4⁺ T cell proliferation is increased within the lymph nodes

• allogenic stimulation of CD4⁺ T cells is also increased

thymus hyperplasia ( J:149560 )

• thymus weight and cellularity is increased by about a third

increased CD4-positive, alpha-beta T cell number ( J:149560 )

• CD4⁺ T cell numbers in the lymph nodes and blood are increased by about a third

increased CD8-positive, alpha-beta T cell number ( J:149560 )

• CD8⁺ T cell numbers in the lymph nodes are slightly increased

abnormal CD4-positive, alpha-beta T cell physiology ( J:149560 )

• CD4⁺ T cells have longer interactions between themselves and with allogenic dendritic cells

• CD4⁺ T cells have a higher affinity for ICAM-coated surfaces

• CD4⁺ T cells have decreased motility through transwell filters

• CD4⁺ T cells transferred into wild-type mice have enhanced enhanced transendothelial migration into lymph nodes

lymph node hyperplasia ( J:149560 )

• axillary, cervical, inguinal and mesenteric lymph nodes are increased in weight and cell number by about a third

increased susceptibility to type IV hypersensitivity reaction ( J:149560 )

• an increase in ear thickness is observed after sensitization and challenge with DNFB

• CD4⁺ T cells in cervical lymph nodes have a higher proliferation rate than those of control mice after DNFB challenge

increased interleukin-2 secretion ( J:149560 )

• IL-2 secretion is enhanced by CD4⁺ T cells in response to allogenic stimulation

increased susceptibility to autoimmune diabetes ( J:149560 )

• diabetes development is accelerated and aggravated after streptozotocin induction with high glucose levels detected

• peripancreatic lymph nodes are enlarged 5-6 days after disease induction

• increased numbers of CD4⁺ T cells are noted in the pancreas 14 days after disease induction compared to controls

hematopoietic system

increased T cell proliferation ( J:149560 )

• homeostatic CD4⁺ T cell proliferation is increased within the lymph nodes

• allogenic stimulation of CD4⁺ T cells is also increased

thymus hyperplasia ( J:149560 )

• thymus weight and cellularity is increased by about a third

increased CD4-positive, alpha-beta T cell number ( J:149560 )

• CD4⁺ T cell numbers in the lymph nodes and blood are increased by about a third

increased CD8-positive, alpha-beta T cell number ( J:149560 )

• CD8⁺ T cell numbers in the lymph nodes are slightly increased

abnormal CD4-positive, alpha-beta T cell physiology ( J:149560 )

• CD4⁺ T cells have longer interactions between themselves and with allogenic dendritic cells

• CD4⁺ T cells have a higher affinity for ICAM-coated surfaces

• CD4⁺ T cells have decreased motility through transwell filters

• CD4⁺ T cells transferred into wild-type mice have enhanced enhanced transendothelial migration into lymph nodes

endocrine/exocrine glands

thymus hyperplasia ( J:149560 )

• thymus weight and cellularity is increased by about a third

cellular

increased T cell proliferation ( J:149560 )

• homeostatic CD4⁺ T cell proliferation is increased within the lymph nodes

• allogenic stimulation of CD4⁺ T cells is also increased

Allelic Composition	Gna12^tm1Citb/Gna12^tm1Citb Gna13^tm2.1Soff/Gna13^tm2.1Soff Tg(Mx1-cre)1Cgn/0
Genetic Background	involves: 129S1/Sv * C57BL/6 * CBA * FVB/N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal blood coagulation ( J:99597 )

• platelet thrombus formation is severely impaired ex vivo after treatment of platelets with polyinosinic-polycytidylic acid (PIPC) to induce recombination

• however, initial adhesion of platelets is similar to wild-type

abnormal platelet physiology ( J:99597 )

• serotonin secretion induced by U46619 plus adrenaline or Par-4 peptide exposure is significantly decreased compared to wild-type cells

• however, thrombin-induced serotonin secretion is not impaired

• absence of a shape change in response to low concentration of stimuli compared to wild-type following polyinosinic-polycytidylic acid (PIPC) treatment

• however, shape change is induced with high concentration of stimuli

• potency of agonists to induce aggregation is reduced but aggregation occurs at all agonist concentrations

decreased platelet aggregation ( J:99597 )

• potency of agonists to induce aggregation is reduced but aggregation occurs at all agonist concentrations

increased bleeding time ( J:99597 )

• very large increase in bleeding time in interferon-responsive tissues

• when bone marrow-derived cells PIPC-treated mice are transplanted into irradiated wild-type mice, 4 weeks later mice have greatly prolonged bleeding times (>20 minutes) compared with mice receiving cells from noninduced controls

hematopoietic system

abnormal platelet physiology ( J:99597 )

• serotonin secretion induced by U46619 plus adrenaline or Par-4 peptide exposure is significantly decreased compared to wild-type cells

• however, thrombin-induced serotonin secretion is not impaired

• absence of a shape change in response to low concentration of stimuli compared to wild-type following polyinosinic-polycytidylic acid (PIPC) treatment

• however, shape change is induced with high concentration of stimuli

• potency of agonists to induce aggregation is reduced but aggregation occurs at all agonist concentrations

decreased platelet aggregation ( J:99597 )

• potency of agonists to induce aggregation is reduced but aggregation occurs at all agonist concentrations

Allelic Composition	Gna12^tm1Citb/Gna12^tm1Citb Gna13^tm2.1Soff/Gna13^tm2.1Soff X/Tg(Myh11-icre/ERT2)1Soff
Genetic Background	involves: 129S1/Sv * FVB/N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

decreased systemic arterial blood pressure ( J:141641 )

• tamoxifen-treated mice exhibit decreased blood pressure following treatment with U46619, vasopressin and endothelin compared to in wild-type mice

• tamoxifen-treated mice exposed to DOCA-salt do not develop hypertension and DOCA-salt treated mice exposed to tamoxifen following the onset of hypertension exhibit a drop in blood pressure compared to in similarly treated wild-type mice

decreased vasoconstriction ( J:141641 )

• tamoxifen-treated mice exhibit reduced vasocontraction in response to angiotensin II, U46619 and endothelin-1 compared to in similarly treated wild-type mice

muscle

decreased vasoconstriction ( J:141641 )

• tamoxifen-treated mice exhibit reduced vasocontraction in response to angiotensin II, U46619 and endothelin-1 compared to in similarly treated wild-type mice

Allelic Composition	Gna12^tm1Citb/Gna12^tm1Citb Gna13^tm1Soff/Gna13^tm1Soff
Genetic Background	involves: 129S1/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gna12^tm1Citb mutation (0 available); any Gna12 mutation (21 available)
Gna13^tm1Soff mutation (0 available); any Gna13 mutation (12 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:77728 )

• resorbed by E9.5 with severe necrosis

embryo

embryonic growth arrest ( J:77728 )

• arrest by E8.25

Allelic Composition	Gna12^tm1Citb/Gna12^tm1Citb Gna13^tm1Soff/Gna13⁺
Genetic Background	involves: 129S1/Sv * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:77728 )

• lethal before E10.5

Allelic Composition	Gna12^tm1Citb/Gna12⁺ Gna13^tm1Soff/Gna13⁺
Genetic Background	involves: 129S1/Sv * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:77728 )

• mice are viable and fertile

Allelic Composition	Gna12^tm1Citb/Gna12⁺ Gna13^tm1Soff/Gna13^tm1Soff
Genetic Background	involves: 129S1/Sv * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:77728 )

• lethal by E10.5

embryo

embryonic growth arrest ( J:77728 )

• growth arrest at E8.5

Allelic Composition	Gna12^tm1Citb/Gna12^tm1Citb Gnaq^tm1Soff/Gnaq^tm1Soff
Genetic Background	involves: 129S1/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gna12^tm1Citb mutation (0 available); any Gna12 mutation (21 available)
Gnaq^tm1Soff mutation (1 available); any Gnaq mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:77728 )

• mutant embryos appear normal until E12, then development appears to stop; embryos begin resorbtion at E13.5

Allelic Composition	Gna12^tm1Citb/Gna12⁺ Gnaq^tm1Soff/Gnaq^tm1Soff
Genetic Background	involves: 129S1/Sv * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:77728 )

• fewer than expected homozygotes were present at P30

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